Chengcheng Zhang

Contrasting outcomes of 16p11.2 microdeletion and microduplication in prenatal diagnosis: phenotypic variability and genetic counseling strategies

Qiu Guo, Li Zhang, Yi Zuo, Jiale Mei et autres

BACKGROUND: Copy number variations (CNVs) in the 16p11.2 region are associated with neurodevelopmental disorders, but they exhibit incomplete penetrance and variable expressivity. Prenatal diagnosis of these CNVs presents significant challenges because of the unpredictable phenotypic outcomes. MATERIALS AND METHODS: We retrospectively analyzed …

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Measurements of suicidal ideation in ecological momentary assessment based on smartphone: a systematic review

Jiaxin Zhu, Haoyang Pan, Jie Zhou, Yuan Gao et autres

cn, nz (code pays fourni par la source)

The effect of cumulative exposure to unhealthy behavioral lifestyles on incident primary dyslipidemia: a prospective study from the Chinese government employee cohort

Ling Li, Yilu Li, Chengcheng Zhang, Jun He et autres

BACKGROUND: While specific unhealthy behavioral lifestyles link to primary dyslipidemia (PD), cumulative effects remain unknown. We quantified the association with incidence of PD with cumulative exposure clustering of lifestyles. METHODS: Eleven thousand eight hundred forty-three government staff enrolled (2018–2020) and followed (2019–2021). …

cn, us (code pays fourni par la source)

Clinical utility and limitations of non‐invasive prenatal testing for chromosome 20 abnormalities: A retrospective study of 83 high‐risk pregnancies

Hu Jian, Chengcheng Zhang, Ling Zeng, Ting Wang et autres

OBJECTIVE: To evaluate the performance of non-invasive prenatal testing (NIPT) in detecting chromosome 20 abnormalities and to investigate the associated pregnancy outcomes. METHODS: This retrospective cohort study included 83 singleton pregnancies referred for invasive prenatal diagnosis following high-risk NIPT results for chromosome …

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Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

Haikuan Yu, Taojin Feng, Chengcheng Zhang, Zhouguang Jiao et autres

Aging is a multidimensional process regulated by the interplay of genetic and environmental factors, with epigenetic alterations serving as a central regulatory hub. Aberrant DNA methylation patterns, dysregulation of histone-modifying enzymes (e.g., SIRT1, EZH2), and non-coding RNA-mediated mechanisms collectively remodel gene expression …

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Effect of Eu2O3 on sintering properties and resistance to slag wetting and penetration of MgO–MgAl2O4 refractory materials

Wenyu Zan, Beiyue Ma, Zhangyan Zhou, Jianhuai Tang et autres

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Deciphering tryptophan metabolism in colorectal cancer through multi-omics analysis

Chengcheng Zhang, Zhijing Rao, Xiangyang Zhan, Lu Yang et autres

Metabolic reprogramming is essential for colorectal cancer (CRC) progression, and recent studies have pointed to tryptophan metabolism as a crucial modulator of the tumor immune microenvironment. In this study, we performed untargeted metabolomics analyses and identified significant differences between CRC tissues and …

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Per- and polyfluoroalkyl substances are linked to incident primary dyslipidaemia: A prospective study from Chinese governmental employee cohort

Ling Li, Feiyun Ouyang, Jun He, Chengcheng Zhang et autres

= 0.009) was observed. Our findings revealed a PFAS mixture exposure on increased incident PD risks and identified PFOS > 29.4 ng/mL as a potentially hazardous substance while aquatic product intake seems to partially attenuate its risk.

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Childhood Trauma and Immune-Mediated Disease: Evidence from Ecological and Prospective Cohort Studies

Chengcheng Zhang, Labibah Qonitatul, Yi Xiao, Yang Zhang et autres

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Per- and Polyfluoroalkyl Substances are Linked to Incident Primary Dyslipidemia: A Prospective Study from Chinese Government Employee Cohort

Ling Li, Feiyun Ouyang, Jun He, Chengcheng Zhang et autres

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Association of types of on-screen content with mental health problems among Chinese adolescents

Chengcheng Zhang, Weijing Peng, Zhiyan Chen, Cong Lai et autres

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Oily Fish Intake and Cardiovascular Diseases: A Mendelian Randomization Study

Xin Liu, Ankun Chen, Yating Lou, Chengcheng Zhang et autres

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