Zhouguang Jiao

Author Correction: Lysosomal “TRAP”: a neotype modality for clearance of viruses and variants

Chengliang Lyu, Zhanlong He, Xiaoming Hu, Shuang Wang et autres

In the original version of this Article, several data-handling errors occurred during preparation of the Source data underlying the Supplementary Figs. S3g, S5c, S5e, and S21c.

cn, jp (code pays fourni par la source)

A single-dose inhalable rAAV-vectored vaccine against mpox virus

Zhouguang Jiao, Zhihui Zheng, Yue Xue, Hongjie Wang et autres

In response to the global mpox outbreak, an inhalable vaccine platform based on rAAV/DJ vectors is developed. This platform represents a needle-free, single-dose, highly immunogenic defense against monkeypox virus (MPXV) and related orthopoxviruses (OPXVs). Two multivalent vaccines, MV-A (encoding M1R/A35R) and MV-B …

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Co-occurrence of blaIMP-4 and blaKPC-2 in a clinical isolate and global evolutionary genomics of Klebsiella grimontii

Yali Zheng, Zhouguang Jiao, Xin Lin, Yu Zhang et autres

Klebsiella grimontii is a recently confirmed member of the Klebsiella oxytoca complex with significant clinical importance. As an opportunistic pathogen, reports of infections it causes are increasing, and the associated threats warrant attention. However, its phylogeny and epidemiological patterns remain poorly studied. …

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Isolation and characterization of phage vB_KpnS_SXK7 against multidrug-resistant Klebsiella pneumoniae and the mechanism of O-antigen-associated phage resistance

Jiao Feng, Li Sun, YJ Li, Yuming Zhang et autres

The increasing prevalence of multidrug-resistant (MDR) Klebsiella pneumoniae necessitates alternative therapeutic strategies. Here, we isolated and characterized a lytic phage, vB_KpnS_SXK7, from hospital sewage and investigated the host's resistance mechanism. Morphological analysis identified it as a siphovirus-type phage. It exhibited a 30-min …

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Co-occurrence of blaIMP-4 and blaKPC-2 in a Clinical Isolate and Global Evolutionary Genomics of Klebsiella grimontii

Yali Zheng, Zhouguang Jiao, Xin Lin, Yu Zhang et autres

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Exploring the Protective Mechanism of Xuebijing Injection Against Sepsis

Zhouguang Jiao, Haikuan Yu, Xuekong Li, Xiaoqing Chen et autres

Purpose: Xuebijing (XBJ) injection is a traditional Chinese medicine (TCM) injection prepared using modern pharmaceutical techniques. Approved as a State Category II New Drug for sepsis, XBJ has demonstrated significant clinical efficacy in China. However, the bioactive components of XBJ and the …

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Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

Haikuan Yu, Taojin Feng, Chengcheng Zhang, Zhouguang Jiao et autres

Aging is a multidimensional process regulated by the interplay of genetic and environmental factors, with epigenetic alterations serving as a central regulatory hub. Aberrant DNA methylation patterns, dysregulation of histone-modifying enzymes (e.g., SIRT1, EZH2), and non-coding RNA-mediated mechanisms collectively remodel gene expression …

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Sex and HBV-Related Age Differences in Cancer Patients in China

Minjie Wang, Zhouguang Jiao, Binbin Han, Zhengrong Liang et autres

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Lysosomal “TRAP”: a neotype modality for clearance of viruses and variants

Chengliang Lyu, Zhanlong He, Xiaoming Hu, Shuang Wang et autres

The binding of viruses to host-entry factor receptors is an essential step for viral infection. Many studies have shown that macrophages can internalize viruses and degrade them in lysosomes for clearance in vivo. Inspired by these natural behaviors and using SARS-CoV-2 as …

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Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization

Tong Ye, Zhouguang Jiao, Xin Li, Zhanlong He et autres

cn, au (code pays fourni par la source)

A Targeted Exosome Therapeutic Confers Both CfDNA Scavenging and Macrophage Polarization for Ameliorating Rheumatoid Arthritis

Zhe Wang, Chuanjie Zhang, Jiaqi Meng, Zhouguang Jiao et autres

Only a minority of rheumatoid arthritis (RA) patients achieve disease remission, so the exploration of additional pathogenic factors and the development of new therapeutics are needed. Here, strong correlations among the cell-free DNA (cfDNA) level and the inflammatory response in clinical synovial …

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Inhalable SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization

Tong Ye, Zhouguang Jiao, Xin Li, Zhanlong He et autres

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