Qing Gu

Lacticaseibacillus rhamnosus -Derived Extracellular Vesicles Alleviate Colitis via PPAR Signaling and the Gut Microbiota–Metabolite Axis

Yingjie Huang, La Xi, Bin Yu, Zihao Zhang et autres

Abstract Intestinal barrier dysfunction is a hallmark of inflammatory bowel disease (IBD), yet effective therapies remain limited, and the mechanisms of probiotic-derived extracellular vesicles (EVs) are poorly understood. Using complementary cell, murine, and intestinal organoid models, we investigated the protective effects of …

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Application of the combined technique of novel transseptal puncture guidewire and steerable sheath in left atrial appendage occlusion: a preliminary feasibility case series

Mei Liang, Wen Wang, Peng Yu Wang, Qing Gu

Objective: Transseptal puncture (TSP) is a critical step in left atrial appendage occlusion (LAAO) but presents certain technical challenges. Conventional puncture needles, due to their inherent rigidity, often cause unpredictable needle tip "bouncing" or upward migration at the moment of septal puncture, …

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Effects of breakfast macronutrient composition on postprandial glycemic control in patients with diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

Jing-Xian Fang, Fang Huang, Qing Gu, Jian Meng et autres

Background: As the first meal of the day, breakfast significantly impacts the daily blood glucose profile of people with diabetes. However, there is currently no consensus on the optimal macronutrient composition of breakfast (i.e., the appropriate ratio of carbohydrates, protein, fat, and …

Surface‐Engineered Selenium Nanozymes for Food Safety: Photoregulated Catalysis, Multimodal Antibacterial Mechanisms, and Emerging Applications in Food Processing, Packaging, and Biosensing

An‐qi Wang, Yi‐ran Wang, Ze‐yu Shi, Yu‐hao Zhang et autres

Selenium nanoparticles (SeNPs) are increasingly recognized as promising nanozymes for food safety because they combine enzyme-mimetic catalytic activity, broad-spectrum antimicrobial effects, and relatively favorable biocompatibility. However, current understanding remains fragmented across materials science, microbiology, and food application research, and a critical synthesis …

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Modulating the fermented gelation behavior of pumpkin (Cucurbita moschata) seed protein isolate through ultrasound-assisted protein glutaminase deamidation

Xiaodan Zhao, Yue Wang, Youling L. Xiong, Qing Gu et autres

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Viable lactic acid bacteria across the production-food-gut continuum: Multi-stress adaptation and robustness engineering

Jing Cui, Li J, Meijuan Ran, Qi Chen et autres

Antioxidant Mechanisms of Lacticaseibacillus paracasei ZFM847 and Its Oxidative Stress Regulation in Multiple Models

Ziqi Chen, Yuting Pan, Y Yuexu Chen, Fangtong Wei et autres

ABSTRACT Oxidative stress is strongly linked to persistent inflammatory responses and contributes to the development and progression of various chronic diseases. This study aimed to identify and investigate the potential antioxidant capacity and mechanisms of Lacticaseibacillus paracasei ZFM847 ( L. paracasei ZFM847) …

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Transforming Brain Health With Neurotechnology Convergence (Part II): Intelligent Neurointervention Systems for Neurological Disorders

Qing Ye, Fei Peng, Chao Pan, Ping Zhang et autres

ABSTRACT Neurological disorders represent a critical domain within global health, necessitating advanced interventions to address complex pathologies such as tumors, functional disorders, and cerebrovascular diseases. Despite the proven benefits of early intervention, current treatment paradigms face significant challenges: (1) limited precision in …

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A Green Photoregulated Quadruple‐Action Selenium Nanozyme Platform for Rapid and Ferroptosis‐Like‐Enhanced Photodynamic Bacterial Killing with Integrated Biosensing Capabilities

Yiran Wang, Donghui Li, Shi Yu, Yanqing Li et autres

Abstract The rise of bacterial infections globally necessitates alternatives to traditional antibiotic therapy. Herein, a photoregulated quadruple‐action selenium nanozyme platform (LG‐CS@SeNPs), synthesized sustainably using food‐grade lauryl gallate‐modified chitosan (LG‐ g ‐CS) as a stabilizer is developed. The LG‐CS@SeNPs exhibit uniform spherical morphology …

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Pulmonary arterial compliance as a long-term prognostic indicator in pulmonary arterial hypertension associated with adult congenital heart disease: results from a National multicenter prospective registry

Qimou Li, Hao Yu, Changming Xiong, Qing Gu et autres

BACKGROUND: Pulmonary arterial compliance (PAC) reflects the pulsatile load and predicts outcome in pulmonary arterial hypertension (PAH). The prognostic role of PAC in the heterogeneous patient population of PAH associated with congenital heart disease (PAH-CHD) is poorly defined. This study aimed to …

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Effects of Fitness Qigong and Tai Chi Exercise Intervention in a Telemedicine Model on diabetic peripheral neuropathy (Preprint)

Yuxuan Wang, Jing-Xian Fang, Suijun Wang, Qing Gu et autres

BACKGROUND Diabetes mellitus has become a rapidly increasing global health problem with vast international influence. Diabetic Peripheral Neuropathy (DPN), a common complication of diabetes, is caused by damage to the peripheral nerves due to prolonged hyperglycemia. OBJECTIVE This single-blind randomized controlled trial …

Development of mapping algorithms for gastric cancer: translating EORTC QLQ-C30 and QLQ-STO22 to EQ-5D-5L health utilities

Huali Zhou, Xianxi Liu, Rong Bao, Liping Qiu et autres

PURPOSE: This study aims to develop a mapping model from the EORTC QLQ-C30 and QLQ-STO22 to the EQ-5D-5L. METHODS: Data were collected from 1059 gastric cancer patients in mainland China. The conceptual overlap between the EORTC QLQ-C30/QLQ-STO22 and EQ-5D-5L was assessed using …

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