Xiangyu Li

Higher frequencies of CNV deletions in bipolar disorder among Chinese Population

Yong Wu, Xiangyu Li, Yaoyao Sun, Chuyi Zhang et autres

cn, me, hk (code pays fourni par la source)

Evidence supporting the role of GIGYF2 in synapse development and autism

Bin Yu, S M Zhu, Linhu Xiao, Guodong Chen et autres

cn, us, de, in, be, fr (code pays fourni par la source)

Circadian clock gates retinal regeneration by orchestrating Cxcl12-dependent immune coordination

Xiangyu Li, Hui Li, Lianxin Wu, Bowen Lu et autres

Abstract The circadian clock orchestrates tissue homeostasis and repair, yet its role in central nervous system (CNS) regeneration remains largely unexplored. Here, we identify the circadian clock as an essential regulator of adult zebrafish retinal regeneration, a CNS model. Retinal injuries induced …

cn (code pays fourni par la source)

Transcriptome sequencing reveals key role of ceRNA in regulating inflammation response after intracerebral hemorrhage

Na Hu, Yufang Yan, Li Deng, Xiangyu Li et autres

cn (code pays fourni par la source)

Loss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP

Xiangyu Li, Ibrahim Bader, Xin Li, Renbin Lu et autres

cn (code pays fourni par la source)

Knockout of Bmal1 in dopaminergic neurons induces ADHD-like symptoms via hyperactive dopamine signaling in male mice

Yichun Zhang, Xin Li, Yong Liu, Xiangyu Li et autres

BACKGROUND: The central circadian clock coordinates daily oscillations in physiology, metabolism and behavior. Disruptions to core circadian clock genes not only perturb sleep-wake rhythms but also contribute to psychiatric disorders. While dopaminergic dysfunction is strongly associated with mental illnesses, the mechanistic connection …

cn (code pays fourni par la source)

Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

Jie Xu, Yi Li, Xiangyu Li, Xuan Ning Sharon Tan et autres

Purpose: Inflammation activates the Jak1-Stat3 signaling pathway in zebrafish Müller glia (MG), leading to their status transition and proliferation following retinal injury. However, the source of Stat3-activating molecules remains unclear. This study aims to explore the expression and function of a Stat3-activating …

cn (code pays fourni par la source)

One-pot synthesis of multifunctional sliver nanoparticles with controlled size for sensitive colorimetric and electrochemiluminescent immunoassay of SARS-CoV-2

Xiangyu Li, Xiaolan Yang, Bo Liu, Jiali Luo et autres

cn, us (code pays fourni par la source)

KCTD10 p.C124W variant contributes to schizophrenia by attenuating LLPS-mediated synapse formation

Chenjun Mu, Pan Liu, Liang Liu, Yaqing Wang et autres

KCTD10, a member of the potassium channel tetramerization domain (KCTD) family, is implicated in neuropsychiatric disorders and functions as a substrate recognition component within the RING-type ubiquitin ligase complex. A rare de novo variant of KCTD10, p.C124W, was identified in schizophrenia cases, …

cn (code pays fourni par la source)

Prenatal low-dose Bisphenol A exposure impacts cortical development via cAMP-PKA-CREB pathway in offspring

Jiang Chu, Jun Guan, Xiangrong Tang, Yichun Zhang et autres

Bisphenol A (BPA) is a widely used plasticizer known to cause various disorders. Despite a global reduction in the use of BPA-containing products, prenatal exposure to low-dose BPA, even those below established safety limits, has been linked to neurological and behavioral deficits …

cn (code pays fourni par la source)

Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration

Hui Xu, Lining Cao, Yuxi Chen, Cuiping Zhou et autres

JOURNAL/nrgr/04.03/01300535-202512000-00031/figure1/v/2025-01-31T122243Z/r/image-tiff Inflammation plays a crucial role in the regeneration of fish and avian retinas. However, how inflammation regulates Müller glia (MG) reprogramming remains unclear. Here, we used single-cell RNA sequencing to investigate the cell heterogeneity and interactions of MG and immune cells …

cn (code pays fourni par la source)

Energy Analysis and Simulation of Activated Sludge Pyrolysis Process

Weihong Zhou, Xiangyu Li, Yuanxin Liu, Yiqiong Zhang et autres

cn (code pays fourni par la source)