Jun Chen

Intestinal subepithelial myofibroblasts in inflammatory bowel disease: fibroblast heterogeneity, fibrosis, and therapeutic targeting

Feng Li, Chao Xu, Jun Chen, Teng Lei et autres

Intestinal fibrosis remains one of the most challenging complications of inflammatory bowel disease (IBD), frequently leading to bowel strictures, impaired intestinal function, and surgical intervention. Among the stromal cell populations involved in intestinal remodeling, intestinal subepithelial myofibroblasts (ISEMFs) have emerged as central …

cn (code pays fourni par la source)

TTC26 scaffolds MINDY3-mediated RACK1 deubiquitination to drive osteoclastogenesis and pathological bone resorption

Yan Gao, Bowen Lai, Ran Yan, Jun He et autres

Osteoclast overactivation is a central driver of bone metabolic disorders such as osteoporosis, and novel drug targets for these diseases continue to be actively explored. Scaffold proteins, which enhance the specificity of deubiquitinase (DUB)-substrate interactions, have emerged as promising therapeutic targets for …

cn (code pays fourni par la source)

Proteinuria in Porcine Kidney Xenografts: Beyond Immunologic Failure

Meng Sun, Dan Zang, Jun Chen

Kinoshita et al1 demonstrate prolonged porcine kidney xenograft survival under TNX-1500, but persistent nephrotic-range proteinuria remains a major limitation to long-term graft durability. The underlying mechanisms driving this functional incompatibility remain insufficiently defined, particularly as xenografts enter early clinical translation. We outline …

cn (code pays fourni par la source)

Directing Neutrophil Fate via Sensory–Immune Interactions Accelerates Diabetic Bone Healing

Xuanyu Qi, Yijia Huang, Yuran Li, Jun Chen et autres

The intractability of diabetic bone defects mainly results from derailed inflammation. While peripheral neuropathy is a common comorbidity, whether sensory dysfunction contributes to uncontrolled inflammation in diabetes is poorly understood. Here, within diabetic bone defects, we show that diminished sensory innervation is …

cn, nz (code pays fourni par la source)

Sirtuin 5-mediated desuccinylation of Slc25a4 inhibits osteoporosis by enhancing mitochondrial respiration

Jun Chen, Xinquan Jiang

Osteoporosis is a prevalent metabolic bone disorder that develops when osteoclast-mediated bone resorption chronically exceeds osteoblast-driven bone formation. The molecular pathways that govern osteogenic dysfunction and connect cellular metabolism to differentiation regulation remain poorly characterized. Here, we identify Sirtuin 5 (Sirt5) as …

cn (code pays fourni par la source)

Photoelectrochemical detection of hyaluronidase activity via enzyme-mediated release of hyaluronic acid-functionalized CdS quantum dots

Jing Hu, Yuting Ding, Jun Chen, Wenjing Xia et autres

cn (code pays fourni par la source)

Safety of osimertinib in Chinese patients with non-small cell lung cancer: a multi-center, prospective, observational study

Hua Zhong, Shunjun Jiang, Wenxiu Yao, Dongqing Lv et autres

BACKGROUND: This prospective, observational study evaluated the real-world safety of osimertinib in a broad Chinese population with non-small cell lung cancer (NSCLC). METHODS: Chinese NSCLC patients who received osimertinib were enrolled and followed up for 12 months. The primary endpoint was the …

cn, Éthiopie (code pays fourni par la source)

Gut microbes and their metabolites in relation to the classic tumor suppressor gene P53: a novel narrative

Jia-Xuan Li, Chenguang Liu, Jun Chen

Gut microbes are considered to be key factors regulating host health and are closely related to tumorigenesis. Although the exact mechanism has not been clearly explained, many studies have shown that specific bacteria can affect cancer-related bioactive molecules, such as p53, Wnt, …

cn (code pays fourni par la source)

SingleCellStat: A Toolkit for Statistical Analysis of Single-Cell Omics Data

L. Zhang, Jun Chen

A suite of statistical methods for analysis of single-cell omics data including linear model-based methods for differential abundance analysis for individual level single-cell RNA-seq data. For more details see Zhang, et al. (Submitted to Bioinformatics)<https://github.com/Lujun995/DiSC_Replication_Code>.

Exploring biosynthetic potential of the endophytic Penicillium turbatum BLH34 using whole-genome sequence analysis and molecular networking

Xuejun Wang, Jun Chen, Chang-li Min, Li Zhang et autres

An in-depth genomic and metabolomic investigation was conducted on the endophytic fungus Penicillium turbatum BLH34, isolated from Macleaya cordata. Hybrid sequencing (Illumina-Nanopore) generated a high-quality 27.9 Mb genome (GC 48.6%) encoding 9798 proteins, with functional annotation linking 5350 genes to the NCBI …

cn, us (code pays fourni par la source)

Molecular mechanisms and therapeutic strategies for small‑cell lung cancer transformation after TKI therapy in EGFR‑mutated lung adenocarcinoma (Review)

Hongbing Zhang, Hongye Gao, Peng Gao, Hongyu Liu et autres

Lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations is a common subtype of non-small cell lung cancer (NSCLC). Although it responds well to EGFR-tyrosine kinase inhibitors (EGFR-TKIs), acquired resistance to EGFR-TKIs inevitably occurs, which limits the use of the EGFR-TKIs. One …

cn (code pays fourni par la source)

1107: GUT MICROBIAL VARIATION RELATED TO PATHOGENESIS AND ADVERSE EVENTS IN A LARGE PRETREATMENT COHORT OF CANCER PATIENTS

Ruben A. Mars, Yang Lü, Vaidhvi Singh, Stephen Johnson et autres