Xinquan Jiang

BMP-2 in oral-maxillofacial bone augmentation: a systematic review and meta-analysis

Guangzheng Yang, Y X Xia, Wentao Shi, Sihan Lin et autres

BACKGROUND: Bone morphogenetic protein-2 (BMP-2) has been widely applied in oral and maxillofacial bone augmentation procedures. This study aimed to evaluate the efficacy and safety associated with the use of BMP-2 in oral and maxillofacial bone augmentation procedures across available randomized controlled …

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Perspective opportunities and challenges in translating dental materials into clinical practice

Yi Ma, Ye Tao, Ling Li, Yongsheng Zhou et autres

The clinical translation of dental materials presents significant opportunities, driven by increasing market demand, supportive regulatory frameworks, and advancements in digital and additive manufacturing technologies. These factors facilitate enhanced personalization, improved biocompatibility, and superior aesthetic and mechanical properties of dental products. However, …

Sirtuin 5-mediated desuccinylation of Slc25a4 inhibits osteoporosis by enhancing mitochondrial respiration

Jun Chen, Xinquan Jiang

Osteoporosis is a prevalent metabolic bone disorder that develops when osteoclast-mediated bone resorption chronically exceeds osteoblast-driven bone formation. The molecular pathways that govern osteogenic dysfunction and connect cellular metabolism to differentiation regulation remain poorly characterized. Here, we identify Sirtuin 5 (Sirt5) as …

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Digital Occlusal-Aesthetic Reconstruction In Dentinogenesis Imperfecta Type II

Jin Xu, Xinquan Jiang, Hui Ling Huang, Jie Wang

Introduction Dentinogenesis imperfecta type II (DGI-II) is a hereditary dental disorder characterized by severe attrition, enamel hypoplasia, and dentin exposure, leading to significant aesthetic and functional impairments. This study investigates a comprehensive digitally-assisted approach to occlusal and aesthetic reconstruction, with a focus …

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Essential tremor-challenged maxillary rehabilitation using a digitally guided all-on-six implant restoration: a case report

S. D. Zhang, Jiarui Cui, Fan He, Jiani Hu et autres

This case report describes a 73-year-old female with essential tremor who experienced significant dissatisfaction with her maxillary complete denture. Her tremor-related dexterity impairment limited her ability to manage removable prostheses, while the excessive denture volume severely disrupted speech. Moreover, her neuromuscular condition …

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Complexed Micelles System Based on Ceria Oxide Nanozyme for Bone Remodeling and ROS Scavenging in Periodontitis

Ning Huang, Lisha Pan, Jiahui Du, Lingyan Cao et autres

Periodontitis is a chronic inflammatory disease caused by dental plaque and characterized by excessive accumulation of reactive oxygen species (ROS). Current treatments often fail to eliminate persistent inflammation and regenerate damaged tissue. Here, an ROS-responsive multifunctional micelle system (HA-PMs@Ce) constructed by self-assembly …

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Self‐Growing Scaffold for Spatial and Border Expansive Regeneration

Liheng Gao, Xinyu Song, Lingxi Meng, Junyi Wang et autres

Tissue regeneration and repair techniques approaching personalized treatment are devoted to fabricating high-precision scaffolds that accurately match the size of the defect. However, scaffolds are difficult to implant in situ for obsolete defects with loss of original space, and the size is …

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Self-cascade ROS-trapping bioreaction system reverses stem cell oxidative stress fate for osteogenesis

Jiawei Yang, Hao Gu, Yuhui Zhu, Jiaojiao Shao et autres

Reactive oxygen species (ROS) scavenging is essential for periodontal regeneration. However, the dynamic change of the applied materials within the ROS-rich environment and the residual oxidation products in the host highly impact periodontal regeneration. This study successfully constructs a bioreaction system via …

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Tissue clearing and its application in dental research

Lingxi Meng, Xinyu Song, Junyi Wang, Wenxuan Shi et autres

Abstract For both animal and human tissues, translucence is an intrinsic property that gives them a milky appearance. This optical property arises due to the combined effects of light absorption and scattering and becomes the main impediment of deep imaging. To overcome …

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Unraveling the influence of channel size and shape in 3D printed ceramic scaffolds on osteogenesis

Ali Entezari, Qianju Wu, Mohammad Mirkhalaf, Zufu Lu et autres

Bone has the capacity to regenerate itself for relatively small defects; however, this regenerative capacity is diminished in critical-size bone defects. The development of synthetic materials has risen as a distinct strategy to address this challenge. Effective synthetic materials to have emerged …

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Micromechanical interlocking-inspired dendritic porous silica-based multimodal resin composites for the tooth restoration

Hongyan Chen, Junjun Wang, Shi Yin, Ruili Wang et autres

Porous silica particles have shown great potential application as reinforcing fillers in the field of dentistry due to their ability to construct the micromechanical interlocking effect at filler-matrix interface. However, how to accurately regulate the pore structure, especially the pore size, to …

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Urchin-like multiscale structured fluorinated hydroxyapatite as versatile filler for caries restoration dental resin composites

S. D. Zhang, Xiao Wang, Shi Yin, Junjun Wang et autres

Caries is one of the most prevalent human diseases, resulting from demineralization of tooth hard tissue caused by acids produced from bacteria, and can progress to pulpal inflammation. Filling restoration with dental resin composites (DRCs) is currently the most common treatment for …

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