Juan Wang

A 57-year-old male with diffuse astrocytoma in the lateral ventricle: case report

Juan Wang, Ye Fan, Wei Zhang

BACKGROUND: Diffuse astrocytoma (DA) is the most common intraparenchymal brain tumor, primarily occurring in the frontal and temporal lobes. However, its occurrence in the lateral ventricles is rare. CASE PRESENTATION: We report a rare case of a 57-year-old male with DA in …

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Salidroside-Pretreated Small Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Promote Blood-Spinal Cord Barrier Repair After Spinal Cord Injury in Mice

Juan Wang, Qian Zhu, Ziyan Zhu, Mingming Zheng et autres

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A Novel FGFR3‐Targeting Antibody‐Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder Cancer

Shu Qin Cui, Xiong-Fei Luo, Guangrui Fan, Jingqi Jiang et autres

Antibody-drug conjugates (ADCs) emerge as a potent cancer therapeutic strategy by enabling precise antigen recognition and efficient intracellular delivery of cytotoxic payloads. In this study, 7-ethyl-9-fluorocamptothecin (A2), a camptothecin derivative, which demonstrates potent tumor-suppressive effects across cellular models, patient-derived organoids (PDOs), and …

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T7 peptide-modified tanshinone IIA-pretreated exosomes promote blood-spinal cord barrier repair after spinal cord injury

Jie Liu, Ziyan Guo, Chenlin Lu, Qian Zhu et autres

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A small-molecule anti-cancer drug for long-acting lysosomal damage

Shulin Zhao, Gui‐Min Xue, Juan Wang, Luyao Hu et autres

Lysosomes represent a promising target for cancer therapy and reducing drug resistance. However, the short treatment time and low efficiency of lysosomal targeting have limited the application in lysosome-targeting anticancer drugs. In this study, we proposed an adhesive-bandage approach and synthesized a …

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Caspase-9 activates β-catenin signaling to promote pulmonary fibrosis

Juan Wang, Bei Qing, Linguo Gu, Hongzuo Chen et autres

BACKGROUND: Pulmonary fibrosis (PF) is a progressive interstitial lung disease marked by extracellular matrix accumulation and epithelial damage, with limited therapeutic options. Alveolar epithelial cell apoptosis is a key pathological hallmark of PF, but the upstream regulators driving this process remain unclear. …

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Immunoregulatory orchestrations in osteoarthritis and mesenchymal stromal cells for therapy

Tongmeng Jiang, Shibo Su, Ruijiao Tian, Yang Jiao et autres

Osteoarthritis (OA) is characterized by the inability of stable and complex joint structures to function as they did, accompanied by inflammation, tissue changes, chronic pain, and neuropathic inflammation. In the past, the primary focus on the causes of joint dysfunction has been …

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Multidimensional Engineering of Extracellular Vesicles for Targeted Delivery and Microglial Reprograming in Spinal Cord Injury Repair

Xiong Wu, Minhao Liu, Juan Wang, Jie Liu et autres

The recovery of neurological function following spinal cord injury (SCI) is primarily constrained by two core pathological mechanisms: neuroinflammation and impaired tissue regeneration. While extracellular vesicles (EVs) have emerged as a promising therapeutic approach, their clinical translation remains limited by the inherent …

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Cellular interactions and Ion channel signatures in atrial fibrillation remodeling: insights from single-cell analysis and machine learning

Bin He, Yan Cheng, Juan Wang, Ya Zhan

Background Atrial structural and electrical remodeling are the pathophysiological mechanisms underlying atrial fibrillation (AF). Although previous studies have offered insights into these changes, the cellular interactions involved in atrial structural remodeling and the ion channel marker genes associated with electrical remodeling in …

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Exosomes Derived from Tanshinone IIA-Pretreated Umbilical Cord Mesenchymal Stem Cells Repair Traumatic Spinal Cord Injury by miR-223–5p/USP8/NLRP3 Axis

Guoqiang Shen, Minhao Liu, Juan Wang, Zhiqiang Qi et autres

Spinal cord injury (SCI) lacks effective therapies, and umbilical cord mesenchymal stem cell (UCMSC)-derived exosomes show promise but require efficacy optimization. This study explored tanshinone IIA (TSA)-pretreated UCMSC exosomes (T-Exos) to enhance neuroprotection and functional recovery post-SCI. T-Exos were isolated from the …

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PromptBio: A Multi-Agent AI Platform for Bioinformatics Data Analysis

Minzhe Zhang, Wenhao Gu, Bo‐Wei Han, Chintan Addoni et autres

Abstract PromptBio is a modular AI platform for scalable, reproducible, and user-adaptable bioinformatics analysis, powered by generative AI and natural language interaction. It supports three complementary modes of analysis designed to meet diverse research needs. PromptGenie is a multi-agent system that enables …

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Correction of upper eyelid retraction following ptosis surgery using Hering’s law: A case report

Runhui Pang, Zhaochuan Liu, Huixing Wang, Juan Wang et autres

RATIONALE: Blepharoptosis is a common disorder characterized by abnormal eyelid position that affects both visual function and esthetics. Postoperative upper eyelid retraction, which is often due to overcorrection, is a major problem. Under normal circumstances, the operation is usually performed on the …

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