Guangrui Fan

CGP60474, a novel MITD1-targeted inhibitor for bladder cancer progression via CDK4/cyclin D1 pathway modulation

Suoshi Jing, Enguang Yang, Xinyu Zhang, Jinpeng Ma et autres

Abstract Targeted therapy holds promise for advanced bladder cancer, but its development is limited by a lack of therapeutic targets. Here, we show that MITD1 is elevated in bladder cancer and associated with poor patient prognosis. We find that MITD1 drives cancer …

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A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer

Yuanfeng Zhang, Enguang Yang, Xinyu Zhang, Yibo Shi et autres

Juglone, a natural naphthoquinone compound, exhibits potent anticancer activity but faces clinical limitations due to poor solubility, low bioavailability, and systemic toxicity. While tumor microenvironment-responsive drug activation strategies offer a promising solution, achieving precise spatial control over the conversion of non-toxic precursors …

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A Novel FGFR3‐Targeting Antibody‐Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder Cancer

Shu Qin Cui, Xiong-Fei Luo, Guangrui Fan, Jingqi Jiang et autres

Antibody-drug conjugates (ADCs) emerge as a potent cancer therapeutic strategy by enabling precise antigen recognition and efficient intracellular delivery of cytotoxic payloads. In this study, 7-ethyl-9-fluorocamptothecin (A2), a camptothecin derivative, which demonstrates potent tumor-suppressive effects across cellular models, patient-derived organoids (PDOs), and …

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Enhanced efficacy of immune checkpoint inhibitors by folate-targeted multifunctional drug through synergistic therapy inducing ferroptosis and immunogenic cell death in bladder cancer

Yibo Shi, Guangrui Fan, Enguang Yang, Yuanfeng Zhang et autres

Purpose: The research aims to elucidate the anti-tumor mechanism of the composite multifunctional folate-targeted drug DIFP-FA through sonodynamic therapy (SDT), chemodynamic therapy (CDT), and chemotherapy, as well as its potential to augment immune checkpoint blockade (ICB) therapy in bladder cancer (BC). Methods: …

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SRC enhanced cisplatin resistance in bladder cancer by reprogramming glycolysis and pentose phosphate pathway

Yuwen Gong, Dongyang Gao, Yibo Shi, Guangrui Fan et autres

The development of cisplatin resistance often results in a grim prognosis in advanced or recurrent bladder cancer. However, effective treatment strategies for cisplatin resistance have not been well established. Herein, we found that overactivation of SRC is associated with cisplatin-resistance. SRC activates …

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A Prostatic Extra-Gastrointestinal Stromal Tumor Treated by Surgery: A Case Report with 7-Year Follow-Up and Review of Literature

Enguang Yang, Suoshi Jing, Guangrui Fan, Ning Fan et autres

BACKGROUND: Prostatic extra-gastrointestinal stromal tumors (EGISTs) are notably uncommon, and the effectiveness of radical prostatectomy in managing these tumors has not been definitively established. CASE SUMMARY: A male patient, aged 71, with a history of two previous bowel resections, reported to the …

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Role of TRIP13 in human cancer development

Chaohu Chen, Li Pan, Guangrui Fan, Enguang Yang et autres

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Comparative study on the efficacy of low-dose and full-dose BCG bladder perfusion therapy

Chaohu Chen, Guangrui Fan, Pan Li, Enguang Yang et autres

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Effect of smoking on the recurrence and progression of non-muscle-invasive bladder cancer

Chaohu Chen, Guangrui Fan, Pan Li, Enguang Yang et autres

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FL118: A potential bladder cancer therapeutic compound targeting H2A.X identified through library screening

Guangrui Fan, Xiong-Fei Luo, Yibo Shi, Ying-Ru Wang et autres

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Mapping global research landscape and trend of nano-drug delivery system for urological cancers: a bibliometric analysis

Yibo Shi, Zean Fu, Xinyi Yu, Yuanfeng Zhang et autres

Aim: We conducted a bibliometric analysis to quantitatively study the development pathway, research hotspots and evolutionary trends of nano-drug delivery systems (NDDS) in treating urological tumors.Materials & methods: We used the Web of Science Core Collection to retrieve the literature related to …

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WITHDRAWN: Comparison of vacuum suction semirigid ureteroscopic laser lithotripsy and flexible ureteroscopic laser lithotripsy for upper ureteral calculi with a diameter ≥ 15mm: a retrospective study

Longhui Lai, Yuanfeng Zhang, Yingru Wang, Guangrui Fan et autres

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