Shuang Li

Basic Clinical Bidirectional Empowerment: Synergistic Breakthrough in Molecular Mechanisms and Clinical Management of Small Cell Cervical Carcinoma

Mengjia Huang, Shuang Li

Small cell carcinoma of the cervix (SCCC) is a rare yet highly aggressive subtype of cervical cancer (CC), characterized by early invasion, high metastatic potential, frequent recurrence, and extremely poor prognosis, which severely impairs women’s physical and mental health. Currently, high-risk human …

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Screening telomere-related genes to predict prognosis, immunotherapy response, and drug sensitivity in esophageal cancer using a machine learning approach

Shuang Li, Fang Chen, Tao Zheng, Wei Jiang et autres

BACKGROUND: Esophageal cancer (EC) is a common malignancy with poor prognosis. Telomeres, composed of repetitive DNA sequences and shelterin complexes, play important roles in tumor biology. However, the prognostic value of telomere-related genes (TRGs) in EC remains unclear. METHODS: TRGs were obtained …

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Multi-omics approaches including single-cell analysis and machine learning were used to identify the roles of telomere-related genes in esophageal squamous cell carcinoma

Shuang Li, Nan Wang, Yazhou Liu, Haitao Ma et autres

BACKGROUND: Telomeres, consisting of TTAGGG repeats and six shelterin proteins, have been extensively studied in oncogenesis due to their crucial role in maintaining genomic stability. Despite these advances, the prognostic significance of telomere-related genes (TRGs) in esophageal squamous cell carcinoma (ESCC) remains …

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From Viral Infection to Genome Reshaping: The Triggering Role of HPV Integration in Cervical Cancer

Junlan Li, Shuang Li

Human papillomavirus (HPV) integration is recognized as a hallmark event in cervical carcinogenesis. However, it does not represent a routine phase of the viral life cycle but rather a stochastic occurrence, often constituting a dead-end pathway for the virus. High-risk human papillomavirus …

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LncRNA HOTTIP promotes LPS‐induced lung epithelial cell injury by recruiting DNMT1 to epigenetically regulate SP‐C

Shuang Li, Shuangjia Li, Zhanqun Gao, Yang Liu

Abstract The objective of this study was to elucidate the involvement of the long noncoding RNA (lncRNA) HOTTIP in acute lung injury and understand the underlying mechanisms. Relevant expression of mRNAs and proteins were assessed by qRT‐PCR and western blot assays. Cell …

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The impact of LncRNA-SOX2-OT/let-7c-3p/SKP2 Axis on head and neck squamous cell carcinoma progression: Insights from bioinformatics analysis and experimental validation

Di Wang, Xue Zhao, Shuang Li, Haixian Guo et autres

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Cuproptosis-related lncRNA SNHG16 as a biomarker for the diagnosis and prognosis of head and neck squamous cell carcinoma

Baoai Han, Shuang Li, Shuo Huang, Jing Huang et autres

Background: We aim to investigate the potential value of cuproptosis-related lncRNA signaling in predicting clinical prognosis and immunotherapy and its relationship with drug sensitivity in head and neck squamous cell carcinoma (HNSCC). Methods: We first identified the lncRNAs associated with cuproptosis genes …

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A prospective prognostic signature for pancreatic adenocarcinoma based on ubiquitination-related mRNA-lncRNA with experimental validation in vitro and vivo

Zhizhou Wang, Qihang Yuan, Xu Chen, Fei Luo et autres

Ubiquitination-related genes (URGs) exerted a crucial part in a variety of human disease disorders; however, their association with pancreatic adenocarcinoma (PAAD) had yet to be clearly described. We aimed to comprehensively characterize the contributions of URGs in PAAD through in silico analysis …

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From Phenomenon to Essence: A Newly Involved lncRNA Kcnq1ot1 Protective Mechanism of Bone Marrow Mesenchymal Stromal Cells in Liver Cirrhosis

Hanjing Zhangdi, Yanan Jiang, Yang Gao, Shuang Li et autres

Abstract Bone marrow mesenchymal stromal cells (BMSCs) have a protective effect against liver cirrhosis. Long noncoding RNAs (lncRNAs) play crucial roles in the progression of liver cirrhosis. Therefore, it is aimed to clarify the lncRNA Kcnq1ot1 involved protective mechanism of BMSCs in …

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A cell cycle–related lncRNA signature predicts the progression-free interval in papillary thyroid carcinoma

Shuang Li, Ming-Yu Ran, Hong Yan Qiao

The cell cycle plays a vital role in tumorigenesis and progression. Long non-coding RNAs (lncRNAs) are key regulators of cell cycle processes. Therefore, understanding cell cycle–related lncRNAs (CCR-lncRNAs) is crucial for determining the prognosis of papillary thyroid carcinoma (PTC). RNA-seq and clinical …

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Epigallocatechin-3-gallate ameliorates inflammatory injury caused by sepsis by regulating the lncRNA PVT1/miR-16-5p/TLR4 axis

Wei Yuan, Shuang Li, Ya-Nan Yang, Hui Gao et autres

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Prognostic value of lncRNAs related to fatty acid metabolism in lung adenocarcinoma and their correlation with tumor microenvironment based on bioinformatics analysis

Ya-Qiang Pan, Ying Xiao, Tao Long, Chao Liu et autres

Background As a key regulator of metabolic pathways, long non-coding RNA (lncRNA) has received much attention for its relationship with reprogrammed fatty acid metabolism (FAM). This study aimed to investigate the role of the FAM-related lncRNAs in the prognostic management of patients …

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