Yazhou Liu

Mechanism Study of Pd-Fe/ZnO Photothermal Catalysis for C2H6 Conversion into High-Value Products: The Key Role of Bimetallic

Haonan Niu, L S Yang, Jingyu Ran, Yazhou Liu et autres

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Review Genomic Hotspot Mining and Characterization for Stable Expression of Therapeutic Protein in Chinese Hamster Ovary Cells

Xuefeng Ding, Yazhou Liu, Lan Luo, Yanfei Cai et autres

The development of rCHO cell lines that stably express therapeutic proteins is crucial for pharmaceutical protein industrial production. In this study, a systematic method was established to identify genomic hotspots for exogenous protein expression in CHO cells and construct stable recombinant CHO …

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On reflection of cylindrical waves in a solid half-space due to a line P source

Yazhou Liu, Yeong-Bin Yang, Hsiao‐Hui Hung, Jie Li et autres

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A Compact Highly Sensitive Cone–Sphere Photoacoustic Spectroscopy Sensor for Real-Time Detection of Dissolved Acetylene in Transformer Oil

Jiao Yang, Yazhou Liu

In this work, we report a compact and highly sensitive photoacoustic spectroscopy (PAS) system based on a cone–sphere coupled photoacoustic cell (CSC-PAC) for real-time detection of trace acetylene (C2H2) dissolved in transformer oil. The sensing module integrates a conical resonator with a …

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Rapid pulsed current diffusion bonding of 6063 Al alloy: Electric-field-driven atomic diffusion

Naibin Chen, Junxiao Chen, Haitao Zhu, Jie Lin Sun et autres

Multi-omics approaches including single-cell analysis and machine learning were used to identify the roles of telomere-related genes in esophageal squamous cell carcinoma

Shuang Li, Nan Wang, Yazhou Liu, Haitao Ma et autres

BACKGROUND: Telomeres, consisting of TTAGGG repeats and six shelterin proteins, have been extensively studied in oncogenesis due to their crucial role in maintaining genomic stability. Despite these advances, the prognostic significance of telomere-related genes (TRGs) in esophageal squamous cell carcinoma (ESCC) remains …

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Efficient Construction of Recombinant CHO Cells for Stable Expression of Therapeutic Proteins Based on New Hotspot ‘LOC’

Yun Chen, Yazhou Liu, Yanfei Cai, Chengfei Wang et autres

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The mechanism of rhizosphere microecological dysbiosis in Pseudostellaria heterophylla under continuous monoculture

Yazhou Liu, Bianhong Zhang, Wenxiong Lin

太子参连作引发的根际微生物组失调被证实是导致产量与品质骤降的关键驱动因素，但其内在作用机制仍有待深入解析。本研究在福建太子参主产区开展多年多地田间实验检测产量变化，并结合高通量测序，探明连作胁迫下根际微生物群落的演替规律及其与产量变化的关系。结果表明：长期连作导致太子参产量显著下降48.63%~63.64%，多糖和环肽B含量分别降低18.39%~26.34%和52.57%~57.32%。连作下不同产区细菌与真菌α多样性显著下降，微生物组成及其功能表现显著差异，其中植物促生菌相对丰度减少1.48%~1.90%，而病原菌丰度增加3.3%~25.09%。共现网络分析表明，连作使细菌网络复杂度降低，其中边数减少20.1%~34.6%，模块度上升3.5%~8.8%；真菌网络则呈现区域异质性响应。核心菌群中病原真菌占比提升。关联分析认为太子参连作障碍的发生是其通过根际微生物“多样性衰减—网络解构—功能失衡”级联效应驱动导致的结果，这为探索靶向修复系统退化，最终恢复土壤健康提供理论依据与技术路径。

Enhancement of Doxorubicin Efficacy in Drug‐Resistant Breast Cancer Cells Through Nucleic Acid Modulation

Yuxuan Qian, Ziyu Wei, Yazhou Liu, Yanfei Cai et autres

Abstract Multidrug resistance (MDR) significantly limits breast cancer chemotherapy effectiveness. Here, we engineered a hyaluronic acid–functionalized graphene oxide (HA‐GO) nanocarrier for co‐delivery of microRNA‐489 and MDR1 antisense oligonucleotide (ASO, MB1) alongside doxorubicin (DOX). Among various nucleic acid ratios, a MiR‐489:MDR1 ASO ratio …

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Integrative single-cell and bulk transcriptomic analysis reveals the landscape of T cell mitotic catastrophe associated genes in esophageal squamous cell carcinoma

Shuang Li, Tao Zheng, Nan Wang, Yazhou Liu et autres

BACKGROUND: Mitotic catastrophe (MC) is a well-recognized endogenous mechanism of tumor cell death, characterized as a delayed cell death process associated with aberrant mitosis. However, its prognostic significance in the context of intratumoral heterogeneity in esophageal squamous cell carcinoma (ESCC) remains largely …

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Microbially mediated ecological resilience in the root-soil continuum underlies Achyranthes bidentata adaptation to continuous cropping

Yazhou Liu, Chunli Zeng, Bianhong Zhang, Chenjing Zhang et autres

Under long-term continuous cropping, Achyranthes bidentata sustained higher yield and quality by maintaining a stable microbial community that fosters positive plant–soil feedback and demonstrates ecological resilience. Our study elucidates how long-term monoculture alters microbial communities across the soil–root continuum. Bacterial diversity increased …

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Simultaneous evolution of geochemical and petrophysical properties of lacustrine carbonaceous shales during thermal maturation

Juncheng Qiao, Guangqing Yang, Zhe Cao, Yazhou Liu et autres

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