Xing Zhang

Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial

Xing Zhang, Bu-Shu Xu, Qiuzhong Pan, Ruiqing Peng et autres

PURPOSE: Advanced sarcomas lack effective maintenance therapies after first-line chemotherapy. We present long-term phase 1 results evaluating multi-antigen stimulated cell therapy-I (MASCT-I), a novel immunotherapy integrating dendritic cell vaccination with adoptive T-cell transfer, as maintenance treatment (NCT03034304). PATIENTS AND METHODS: Thirty-one patients …

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Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng

Sickle cell disease and cancer represent fundamentally distinct classes of human disease-one is driven by a defined mutation in β-globin, whereas the other arises through complex genetic and epigenetic alterations that reshape cellular identity and behavior. Despite these differences, both contexts illustrate …

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CD147 – an inducer of NF-κB within the post-traumatic immune response in a murine trauma model

Felix M. Bläsius, Kang Qin, You Li, Xing Zhang et autres

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Brigimadlin versus Doxorubicin in Advanced Dedifferentiated Liposarcoma: Efficacy, Safety, and Translational Data from Brightline-1, a Randomized Phase II/III Trial

Patrick Schöffski, Roberta Sanfilippo, Javier Martín‐Broto, Akira Kawai et autres

PURPOSE: The phase 2/3 Brightline-1 trial (NCT05218499) assessed the MDM2-p53 antagonist brigimadlin versus standard-of-care doxorubicin as first-line treatment for MDM2-amplified, locally advanced/metastatic dedifferentiated liposarcoma (DDLPS). PATIENTS AND METHODS: Patients with MDM2-amplified, locally advanced or metastatic, unresectable, progressive, or recurrent DDLPS were eligible. …

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Bedside ultrasound-assisted manual reduction in ultrasound-selected, non-transient pediatric intussusception: a single-center experience

Xing Zhang, HongYan Chen, Jing Xiong

Purpose: To evaluate the feasibility and safety of bedside, single-operator ultrasound-assisted manual reduction (UAMR) in ultrasound-selected, non-transient pediatric intussusception in routine clinical practice. Methods: We retrospectively reviewed 119 ultrasound-selected, non-transient pediatric intussusception encounters managed with bedside UAMR between March 2023 and December …

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Knowledge, attitude, and practice of clinicians regarding antimicrobial stewardship: a cross-sectional study in a tertiary hospital of East China

Yonghui Ma, Yujie Xia, Xing Zhang, Xia Yue et autres

Antimicrobial resistance (AR) is an increasingly significant public health challenge worldwide owing to its negative impact on morbidity, mortality, and healthcare costs. Antimicrobial stewardship (AMS) is an important method for curbing AR. The knowledge-attitude-practice (KAP) model is a well-established theoretical framework applied …

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Supplementary Table S1 from Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade

Dong‐Chun Hong, Jing Yang, Cong Sun, Yuan-Tao Liu et autres

Clinical characteristics of patients in RIS group and SARC group as a whole, or for WES, or for mRNA- seq.

Supplementary Table S2 from Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade

Dong‐Chun Hong, Jing Yang, Cong Sun, Yuan-Tao Liu et autres

Differentially expressed genes (DEG), possible fusion genes and alternative splicing events, and the anti-tumor immunity scores and proliferation module scores of each sample.

Supplementary Figure S3 from Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade

Dong‐Chun Hong, Jing Yang, Cong Sun, Yuan-Tao Liu et autres

Comparison between RIS group and SARC group in mRNA-seq and WES data.(A) Expression levels of IDO and CTLA-4 in the RIS group and SARC group in mRNA-seq.(B) The anti-tumor immunity score and the proliferation module score of the RIFS group and the …

Supplementary Figure S1 from Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade

Dong‐Chun Hong, Jing Yang, Cong Sun, Yuan-Tao Liu et autres

The flowchart showing patient screening and identification, and analysis steps for mRNA-seq and WES data. FS: fibrosarcoma; OS: osteosarcoma.

Supplementary Figure S4 from Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade

Dong‐Chun Hong, Jing Yang, Cong Sun, Yuan-Tao Liu et autres

The landscape of copy number variants and results for blood detection.༈A༉Top genes in copy number changes in RIS and SARC groups filtered by COSMIC gene list.༈B༉Top genes in copy number changes in RIFS and FS subtypes.༈C༉Top genes in copy number changes in …

Supplementary Table S3 from Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade

Dong‐Chun Hong, Jing Yang, Cong Sun, Yuan-Tao Liu et autres

Clinical characteristics of patients treated with chemotherapy alone and chemotherapy plus anti-PD-1 antibody in RIS group.