Accès ouvert
2026
article
OpenAlex
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng
Sickle cell disease and cancer represent fundamentally distinct classes of human disease-one is driven by a defined mutation in β-globin, whereas the other arises through complex genetic and epigenetic alterations that reshape cellular identity and behavior. Despite these differences, both contexts illustrate …
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2026
preprint
OpenAlex
Jisun Lee, Jujun Zhou, John R. Horton, Meigen Yu et autres
B-cell leukemia/lymphoma 11B (BCL11B), despite its name, is a key regulator of T-cell development, specification, and T-cell malignancies. BCL11B contains a bipartite DNA binding domain composed of two C2H2 zinc finger arrays: low-affinity ZF2-3 and high affinity ZF4-6. These arrays function as …
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2026
preprint
OpenAlex
Meigen Yu, Puspa Das, John R. Horton, Jujun Zhou et autres
BCL11A is a transcription factor crucial for neurodevelopment and hematopoiesis. It regulates the developmental switch from fetal hemoglobin (HbF) to adult hemoglobin and is a major therapeutic target for sickle cell disease and β-thalassemia. BCL11A exists in multiple isoforms, including the L …
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2025
article
OpenAlex
John R. Horton, Meigen Yu, Jujun Zhou, Melody L. Tran et autres
BCL11A, a transcription factor, is vital for hematopoiesis, including B and T cell maturation and the fetal-to-adult hemoglobin switch. Mutations in BCL11A are linked to neurodevelopmental disorders. BCL11A contains two DNA-binding zinc-finger arrays, low-affinity ZF2-3 and high-affinity ZF4-6, separated by a 300-amino-acid …
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2023
article
OpenAlex
Meigen Yu, Hui Ye, Ruth B. De-Paula, Carl Grant Mangleburg et autres
Heterozygous variants in the glucocerebrosidase (GBA) gene are common and potent risk factors for Parkinson's disease (PD). GBA also causes the autosomal recessive lysosomal storage disorder (LSD), Gaucher disease, and emerging evidence from human genetics implicates many other LSD genes in PD …
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Accès ouvert
2022
review
OpenAlex
Hui Ye, Laurie A. Robak, Meigen Yu, Matthew D. Cykowski et autres
Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous, resisting distillation to a single, cohesive disorder. Instead, each affected individual develops a virtually unique form of Parkinson's syndrome. Clinical manifestations consist of variable motor and nonmotor features, and myriad overlaps are recognized …
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Accès ouvert
2022
preprint
OpenAlex
Meigen Yu, Hui Ye, Ruth B. De-Paula, Carl Grant Mangleburg et autres
ABSTRACT Heterozygous variants in the glucocerebrosidase ( GBA ) gene are common and potent risk factors for Parkinson’s disease (PD). GBA also causes the autosomal recessive lysosomal storage disorder (LSD), Gaucher disease, and emerging evidence from human genetics implicates many other LSD …
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(code pays fourni par la source)