Lu Liu

2775P A phase I dose escalation and expansion study of ZG006, a trispecific T cell engager targeting DLL3/DLL3/CD3, as monotherapy in patients with refractory small cell lung cancer (SCLC) or neuroendocrine carcinoma (NEC)

Q. Wang, Xiaoyun Chai, Rongbo Lin, Limin Zheng et autres

cn, hk (code pays fourni par la source)

Polystyrene nanoplastics induced transgenerational reproductive toxicity in Caenorhabditis elegans through enhanced DNA damage accompanied by DNA repair inhibition

Fanghao Li, Zhiyuan Wang, Jian‐Jun Xie, Zhenyu Ji et autres

Microplastics (MPs) are omnipresent environmental pollutants posing potential impacts on organisms. To explore the transgenerational effects of polystyrene nanoplastics (PS-NPs) and the molecular mechanisms at environmental relevant concentrations, Caenorhabditis elegans (C.elegans) was applied as an in vivo model. Worms were incubated with …

cn (code pays fourni par la source)

MRI Parameters and Clinicopathologic Features in Predicting Hepatocellular Carcinomas With Aggressive-Related Marker Expression, Defined by Epithelial Cell Adhesion Molecule and Glypican-3 Status

Y Li, Huo Lei, Lu Liu, Ningyang Jia et autres

Objective: Epithelial cell adhesion molecule (EpCAM) and glypican-3 (GPC3) are associated with a poor survival rate in hepatocellular carcinoma (HCC). Predicting aggressive HCC non-invasively should be investigated using preoperative gadoxetic acid-enhanced MRI and clinical characteristics. Methods: This retrospective study examined 134 patients …

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KHDRBS1 regulates the pentose phosphate pathway and malignancy of GBM through SNORD51-mediated polyadenylation of ZBED6 pre-mRNA

Xiaoyu Liu, Xiaobai Liu, Weiwei Dong, Ping Wang et autres

Glioblastoma is one of the most common and aggressive primary brain tumors. The aberration of metabolism is the important character of GBM cells and is tightly related to the malignancy of GBM. We mainly verified the regulatory effects of KHDRBS1, SNORD51 and …

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686TiP Preliminary phase I results from a first-in-human study of ZG006, a trispecific anti-T cell engager targeting CD3/DLL3/DLL3, as monotherapy in patients with advanced small cell lung cancer or neuroendocrine carcinoma

Q. Wang, Xiaoyun Chai, R H Lin, Liqiang Zheng et autres

cn, hk (code pays fourni par la source)

Research on the characteristics of cathode spots and plasmas in vacuum arc with long gap distance

Lu Liu, Shaobo Liu, Zhikang Yuan, Liang Chen et autres

Vacuum circuit breakers are widely used in various voltage levels of power systems. The vacuum arcs which are composed of metal vapor and plasmas are generated during the operation of vacuum circuit breakers. Cathode spots are the source of metal vapor and …

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Evolution characteristics of vacuum arc plasma under two types of electrode structures based on the principle of two-colorimetric diagnosis

Shaobo Liu, Zhiwen Yuan, Lu Liu, P. Ya et autres

The diffusion of vacuum arc directly affects the breaking ability of vacuum circuit breaker. The plasma distribution in the arc gap during initial diffusion is the main object to control the vacuum arc. The electrode structure is the main way to control …

cn (code pays fourni par la source)

Discovery of hydroxamate as a promising scaffold dually inhibiting metallo- and serine-β-lactamases

Xiaorong Wu, Weiya Chen, Lu Liu, Ke‐Wu Yang

cn (code pays fourni par la source)

Intraspecific Structure of Liza affinis Inferred from Mitochondrial Cytochrome b Variations

Lu Liu, Lin Lin, Tianxiang Gao, Dianrong Sun et autres

Abstract Liza affinis (Eastern keelback mullet) is a commercial species in the East China Sea (ECS) and South China Sea (SCS). However, L. affinis has suffered from a severe recession caused by overfishing. Thus, assessment of population genetic structure is necessary to …

cn (code pays fourni par la source)

Supplementary Material and Methods from EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition

Ya‐Ting Hsu, Paweł A. Osmulski, Yao Wang, Yi‐Wen Huang et autres

Transgenic mice,Immunofluorescence staining and image quantification, Proliferation and migration assays, ChIP-seq and network-based pathway analysis, TCGA expression analysis, CRISPR/Cas9 genome-editing of EpCAM, Apoptosis assay, Nanomechanical imaging of cells with Atomic Force Microscopy (AFM), Probing of cell surface with molecular recognition AFM

Supplementary Material and Methods from EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition

Ya‐Ting Hsu, Paweł A. Osmulski, Yao Wang, Yi‐Wen Huang et autres

Transgenic mice,Immunofluorescence staining and image quantification, Proliferation and migration assays, ChIP-seq and network-based pathway analysis, TCGA expression analysis, CRISPR/Cas9 genome-editing of EpCAM, Apoptosis assay, Nanomechanical imaging of cells with Atomic Force Microscopy (AFM), Probing of cell surface with molecular recognition AFM

Highly-purified rapidly expanding clones, RECs, are superior for functional-mitochondrial transfer

Jiahao Yang, Lu Liu, Yasuaki Oda, Keisuke Wada et autres

Abstract Background Mitochondrial dysfunction caused by mutations in mitochondrial DNA (mtDNA) or nuclear DNA, which codes for mitochondrial components, are known to be associated with various genetic and congenital disorders. These mitochondrial disorders not only impair energy production but also affect mitochondrial …

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