Weiwei Dong

α-ALA Attenuates Cardiac Injury in Diabetic Heart Disease Mice by Modulating Inflammation and AMPKα1

Xuan Liu, Landi Wang, Weiwei Dong, Yu‐Chao Wang et autres

Introduction: Diabetic heart disease (DHD) is systolic and/or diastolic dysfunction of the heart muscle that occurs in patients with the presence of Type 2 diabetes mellitus. AMPKα1, a key regulator of glucose metabolism, has been shown to promote glucose uptake and catabolism. …

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Increased prevalence of cardio-cerebrovascular risk factors during the COVID-19 pandemic lockdown: a large, single center, cross-sectional study

Jinjing Lu, Yanyan Shen, Lanying Li, Yuqiang Mao et autres

BACKGROUND: The COVID-19 pandemic prompted over 170 countries to implement lockdowns, significantly altering lifestyles and potentially impacting cardio-cerebrovascular risk factors (CCVRFs). This study evaluates changes in CCVRFs before, during, and after the lockdown, stratified by population subgroups. We aim to mitigate the …

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KHDRBS1 regulates the pentose phosphate pathway and malignancy of GBM through SNORD51-mediated polyadenylation of ZBED6 pre-mRNA

Xiaoyu Liu, Xiaobai Liu, Weiwei Dong, Ping Wang et autres

Glioblastoma is one of the most common and aggressive primary brain tumors. The aberration of metabolism is the important character of GBM cells and is tightly related to the malignancy of GBM. We mainly verified the regulatory effects of KHDRBS1, SNORD51 and …

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Gender and race disparities in the prevalence of chronic kidney disease among individuals with hypertension in the United States, 2001–2016

Jing Shen, Baoquan Wang, Li Jing, T Chen et autres

Background: Chronic kidney disease (CKD) is a common complication among individuals with hypertension. We aimed to identify the prevalence of CKD and the sex and race disparities within the hypertensive population in the United States from 2001-2016. Methods: A total of 16,148 …

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Association of the blood levels of specific volatile organic compounds with nonfatal cardio-cerebrovascular events in US adults

Jing Li, T Chen, Zhiyong Yang, Weiwei Dong

BACKGROUND: Cardio-cerebrovascular diseases constitute a major global public health burden. Volatile organic compounds (VOCs) exposure has become progressively severe, endangering human health and becoming one of the main concerns in environmental pollution. The associations of VOCs exposure with nonfatal cardio-cerebrovascular events have …

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Association between dietary selenium intake and severe abdominal aortic calcification in the United States: a cross-sectional study

Weiwei Dong, Xiaobai Liu, Lu Ma, Zhiyong Yang

Abdominal aortic calcification (AAC) is an important predictor of cardiovascular disease. The purpose of the current study was to detect the association between dietary selenium intake and severe AAC. We included 2651 participants from the National Health and Nutrition Examination Survey (NHANES, …

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m5C modification of LINC00324 promotes angiogenesis in glioma through CBX3/VEGFR2 pathway

Aini Pan, Yixue Xue, Xuelei Ruan, Weiwei Dong et autres

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RBMS3-induced circHECTD1 encoded a novel protein to suppress the vasculogenic mimicry formation in glioblastoma multiforme

Xuelei Ruan, Yunhui Liu, Ping Wang, Libo Liu et autres

Glioblastoma multiforme (GBM) is a highly vascularized malignant cancer of the central nervous system, and the presence of vasculogenic mimicry (VM) severely limits the effectiveness of anti-vascular therapy. In this study, we identified downregulated circHECTD1, which acted as a key VM-suppressed factor …

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SUMOylation of RALY promotes vasculogenic mimicry in glioma cells via the FOXD1/DKK1 pathway

Shuo Cao, Di Wang, Ping Wang, Yunhui Liu et autres

Human malignant gliomas are the most common and aggressive primary malignant tumors of the human central nervous system. Vasculogenic mimicry (VM), which refers to the formation of a tumor blood supply system independently of endothelial cells, contributes to the malignant progression of …

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Pseudogene MAPK6P4-encoded functional peptide promotes glioblastoma vasculogenic mimicry development

Mengyang Zhang, Yubo Zhao, Xiaobai Liu, Xuelei Ruan et autres

Glioma is the most common primary malignancy of the central nervous system. Glioblastoma (GBM) has the highest degree of malignancy among the gliomas and the strongest resistance to chemotherapy and radiotherapy. Vasculogenic mimicry (VM) provides tumor cells with a blood supply independent …

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Association of nickel exposure with body mass index, waist circumference and incidence of obesity in US adults

Weiwei Dong, Zhiyong Yang

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A novel peptide P1-121aa encoded by STK24P1 regulates vasculogenic mimicry via ELF2 phosphorylation in glioblastoma

Tianyun Li, Xiaobai Liu, Xuelei Ruan, Weiwei Dong et autres

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