Bin Liu

Simultaneous Inhibition of PARP-1 and CK2α by Novel Benzothieno[3,2- d ]pyrimidin-4(1 H )-one Derivatives: A Promising Strategy to Combat Homologous Recombination Deficiency-Independent Tumors and Metastasis

Yuanjiang Wang, Yanyan Liu, Hanxu Yu, Bin Liu et autres

Abstract Poly(ADP-ribose) polymerase 1 (PARP-1) inhibitors yield robust clinical benefits yet only work for homologous recombination deficiency (HRD) patients. To expand their utility and resolve clinical drawbacks, we synthesized dual PARP-1/casein kinase II alpha (CK2α) inhibitors built on benzofuran/benzothieno[3,2-d]pyrimidin-4(1H)-one cores with methyl …

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Integration of algorithm optimization and interpretability: Non-destructive age identification of forest-cultivated dried ginseng using hyperspectral imaging

Mingxuan Xue, Bin Liu, Shuqi Zhang, Yonghua Xu et autres

Forest cultivated dried ginseng is a valuable medicinal material whose cultivation age influences its quality and market value, yet conventional identification methods are often destructive or inefficient. In this study, hyperspectral imaging (HSI) combined with a Random Forest model optimized by Improved …

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Infantile hypophosphatasia in a Chinese patient: identification and characterization of novel compound heterozygous ALPL mutations

Wenjuan Li, Shuhan Zeng, Jun Jiang, Bin Liu

Here we report a Chinese infant with hypophosphatasia (HPP) carrying alkaline phosphatase (ALPL) gene mutations. Genetic analysis of the patient's ALPL gene revealed a maternally inherited canonical splice-site variant (c.997+1G>T; pathogenic; PVS1 + PM2 + PP4) and a paternally inherited missense variant …

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A Novel FGF2‐Targeted Inhibitor (N‐trans‐feruloyloctopamine) Suppresses UVB‐Induced Skin Damage and Hyperpigmentation

Bowei Li, Bin Liu, Jingyuan Yang, Shuang Wu et autres

ABSTRACT Ultraviolet B (UVB) radiation significantly damages skin and causes hyperpigmentation, but effective molecular interventions are limited. This study explores fibroblast growth factor 2's (FGF2) role in UVB‐induced skin damage and identifies N‐trans‐feruloyloctopamine (NFO) as a novel FGF2 inhibitor. NFO effectively reduces …

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ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4–SPTLC1 axis

Yue Zhao, Shu Li, Linhong Jiang, Ying Jie Zhao et autres

Background Cocaine-induced endoplasmic reticulum (ER) stress has been increasingly recognized, but its neuronal specificity and functional significance remain unclear. Because the ER is also a major site for lipid and sphingolipid biosynthesis, cocaine-triggered ER stress may influence metabolic pathways linked to cellular …

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[Analysis of factors associated with false-positive results and optimal positivity thresholds of quantitative fecal immunochemical test in colorectal cancer screening].

Yibin Zhou, Wenming Wu, Chunhui Zhu, Tingting Pan et autres

The risk of false-positive results in quantitative FIT varies across different subgroups. Adopting the optimal thresholds could improve the specificity and reduce the FPR of quantitative FIT for CRC screening.

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A novel technique to remove bladder foreign body with combined single port laparoscopy and cystoscopy in carbon dioxide circumstances

Gang Han, Bin Liu, Chen Li, Ziqi Wang et autres

The urinary bladder is the most usual site of foreign bodies in the genitourinary tract. Herein, a 33 years old man who has inserted 29 olive shaped balls with high-strength magnetism (so called “Buck ball”) into his bladder. We describe a technique …

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Multi-strategy enhanced privacy protection for multimodal data in federated learning

Hanjie Xu, Shihua Zhang, Jiyuan Chen, Bin Liu et autres

Federated learning protects privacy while training on distributed clients, facing challenges from Non-IID data and sensitive information. This paper introduces a multi-strategy privacy-preserving framework using Local Differential Privacy (LDP) for client privacy, a Genetic Algorithm (GA) for robust aggregation of noisy updates, …

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The role of systemic immune inflammation index in predicting melanoma

Chunli Wang, Long Zeng, Mengjie Mao, Chunyu Wang et autres

Many malignancies arise in the context of chronic infection, persistent irritation, or unresolved inflammation, and the inflammatory environment is closely associated with tumor cell proliferation and metastatic spread. The systemic immune-inflammation index (SII), calculated from peripheral lymphocyte, neutrophil, and platelet counts, has …

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Three new cyclopeptides from the Lycii cortex

Peipei Liang, Ya-Di Duan, Mengnan Zhou, Chengyuan Su et autres

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Toxin‐Responsive Antigen Reservoir Nanovaccines for In Situ Vaccination Against Bacterial Infection Recurrence

Qize Xuan, Feng Jiang, Xinchi Qiao, Yuan Gao et autres

Abstract Current bacterial vaccines remain unsatisfactory in combating the increasing recurrence rates of drug‐resistant bacterial infections due to the inefficient activation of antigen presenting cells and the absence of long‐term immune memory. Here, a therapeutic nanovaccine (RBCM@PPPB) is engineered based on a …

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From bench to bedside: targeting ferroptosis and mitochondrial damage in the treatment of diabetic cardiomyopathy

Bin Liu, Qing Jin, Yi Sun, Zhi Ming Yang et autres

Diabetic cardiomyopathy (DCM) is a common and fatal cardiac complication caused by diabetes, with its pathogenesis involving various forms of cell death and mitochondrial dysfunction, particularly ferroptosis and mitochondrial injury. Recent studies have indicated that ferroptosis and mitochondrial damage play crucial roles …

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