Qize Xuan

Environmental Proteinopathy: Nanoplastics as Physicochemical Nanosurfaces for Proteostatic Disruption beyond Conventional Toxicological Endpoints

Chao Chen, Yan Gan, Yifan Feng, Huan Mao et autres

cn, us, cz (code pays fourni par la source)

Spatiotemporally controlled peroxynitrite nanogenerator disarms tumor physical barriers to potentiate immune activation

Qize Xuan, Jiazhe Cai, Qian Hu, Xinchi Qiao et autres

cn, es, sg (code pays fourni par la source)

TDCPP induces ferroptosis in THP-1 macrophages through mitochondrial regulation of Fe2 + homeostasis

Susu Wang, Chongli Shi, Ruiping Lai, Chen Wang et autres

Widespread environmental exposure to tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a commonly used organophosphate esters, has raised significant concerns due to its structural similarity to organophosphate pesticides with known immunotoxicity. However, the immunotoxic and underlying mechanisms remain insufficiently understood. In this study, we used …

sg, cn (code pays fourni par la source)

Recyclable amyloid-based magnetic nanonets for active capture and removal of nanoplastics from water

Qize Xuan, Xinyu Yu, Yifan Feng, Xinchi Qiao et autres

cn, ch, nl, sg, es (code pays fourni par la source)

Dual-engineering metalloimmunotherapy mediates Staphylococcus aureus virulence silencing and biofilm immune microenvironment reprogramming against implant-associated infections

Feng Jiang, Qize Xuan, Yujie Hu, Zun Ren et autres

Implant-associated infections (IAIs) caused by Staphylococcus aureus ( S. aureus ) are notoriously recalcitrant to treatment due to the self-reinforcing interplay between bacterial virulence and a suppressive biofilm immune microenvironment (BIME). Here, we present a dual-engineering metalloimmunotherapy nanoplatform that synchronously silences bacterial …

cn (code pays fourni par la source)

Waterborne Nanoplastics: An Emerging Neurodegenerative Threat Amplified by Aberrant Phase Separation and Oligomerization

Qize Xuan, Yifan Feng, Qian Hu, Chao Chen et autres

Recommendations W ith annual production exceeding 400 million metric tons and global recycling rates failing to reach 10%, plastic pollution presents a critical environmental challenge.Consequently, more than 90% of plastic waste accumulates in ecosystems, largely in water bodies.1 There, it fragments through …

cn (code pays fourni par la source)

Photo-reversible amyloid nanoNETs for regenerative antimicrobial therapies

Qize Xuan, Hui Li, Yuan Gao, Xinchi Qiao et autres

Drug-resistant bacterial infections, exacerbated by antibiotic resistance and biofilm resilience, disrupt tissue repair through dysregulated inflammation and impaired regeneration. Neutrophil extracellular traps (NETs) play a crucial role in endogenous immunity by entrapping and eliminating pathogens, inspiring the development of synthetic biomaterials that …

cn, ch, us, sg (code pays fourni par la source)

Photo-reversible amyloid nanoNETs for regenerative antimicrobial therapies

Qize Xuan, Hui Li, Yuan Gao, Xinchi Qiao et autres

Drug-resistant bacterial infections, exacerbated by antibiotic resistance and biofilm resilience, disrupt tissue repair through dysregulated inflammation and impaired regeneration. Neutrophil extracellular traps (NETs) play a crucial role in endogenous immunity by entrapping and eliminating pathogens, inspiring the development of synthetic biomaterials that …

Immunotoxicity and cancer risk exacerbation induced by tris(1,3-dichloro-2-propyl) phosphate exposure: insights from macrophage inflammatory responses and in vivo tumor models

Susu Wang, Chongli Shi, Ruiping Lai, Chen Wang et autres

Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is widely detected in human tissues and associated with significant health risks. However, the immunotoxicity and health risk mechanisms of long-term TDCPP exposure remain poorly understood. This study integrates mRNA sequencing (mRNA-seq) and high-throughput cytokine profiling to elucidate key …

sg, cn (code pays fourni par la source)

Toxin‐Responsive Antigen Reservoir Nanovaccines for In Situ Vaccination Against Bacterial Infection Recurrence

Qize Xuan, Feng Jiang, Xinchi Qiao, Yuan Gao et autres

Abstract Current bacterial vaccines remain unsatisfactory in combating the increasing recurrence rates of drug‐resistant bacterial infections due to the inefficient activation of antigen presenting cells and the absence of long‐term immune memory. Here, a therapeutic nanovaccine (RBCM@PPPB) is engineered based on a …

cn, ch, us (code pays fourni par la source)

Functional Amyloid Phenol-Soluble Modulin α1-Targeting Photothermal Nanoplatform for Effective Elimination of Biofilm-Associated Infections

Chao Chen, Yuan Gao, Xinchi Qiao, Xinyu Yu et autres

Biofilm-associated infections (BAIs) often lead to chronic infections and implant failure and are challenging to treat due to their resilience and complex structure, especially the extracellular polymeric substance (EPS). Phenol-soluble modulin α1 (PSMα1), a key biofilm-forming protein in methicillin-resistant Staphylococcus aureus (MRSA), …

cn (code pays fourni par la source)

Amyloid‐Templated Ceria Nanozyme Reinforced Microneedle for Diabetic Wound Treatments

Qize Xuan, Yuan Gao, Xinchi Qiao, Tonghui Jin et autres

Abstract Amyloid fibrils have emerged as excellent templates and building blocks for the development of ordered functional materials with considerable potential in biomedical applications. Here, lysozyme amyloid fibrils (Lys‐AFs) are employed as templates for the in situ synthesis of ceria nanozymes (Lys‐AFs‐Ceria) …

cn, ch, us (code pays fourni par la source)