Miao Chen

Impaired Glycolysis Leads to Defective Efferocytosis and Impaired Plaque Resolution in Tet2 Clonal Hematopoiesis

Mustafa Yalçınkaya, Cheng-Chieh Hsu, Linke Li, Ranran Wang et autres

BACKGROUND: Clonal hematopoiesis (CH) arising from mutations in hematopoietic genes has been identified as an important risk factor for atherosclerotic cardiovascular disease. Despite the established role of some CH mutations in promoting atherosclerosis progression, their role in clinically relevant LDL (low-density lipoprotein) …

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A prospective, phase IV study of ixazomib, pomalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma

Runfeng Zhang, Hong Yu, Miao Chen, Xiaoqi Qin et autres

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Isoquercetin targets histone methyltransferase G9a to promote BDNF expression and improve cerebral ischemia-reperfusion injury

Limin Hong, Hangfei Wang, Xiyuan Lin, Bo Sun et autres

Reperfusion therapies following stroke can contribute to further brain injury.Inhibition of G9a has been demonstrated to increase BDNF expression, thereby exerting neuroprotective effects. Isoquercetin (ISO) has shown neuroprotective potential, but its molecular mechanisms are not fully known. This study aimed to investigate …

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An Integrated Data Asset Valuation Model for Internet Financial Enterprises Based on a Multi-Period Excess Earnings Method

Miao Chen, Baoqiang Li

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Phenylboronic acid modification and small-molecule assembly to enhance the safety of resiquimod and its synergistic anti-tumor efficacy with paclitaxel

Ziqi Liu, Manzhen Li, Pengxin Li, Miao Chen et autres

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Peroxymonosulfate-assisted photocatalytic degradation of levofloxacin by hollow Bi2WO6/TiO2 nanotube arrays S-scheme heterojunction: Kinetics, mechanism and toxicity assessment

Wenxiang Xia, Miao Chen, Yuyuan Huang, Xin Ji et autres

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Supply Chain Finance and Corporate Collaborative Innovation:Empirical Evidence from China

Aiping Wang, Miao Chen, Haifeng Hu

Using panel data from China’s A-share listed manufacturing firms (2012–2022), this study examines whether supply chain finance (SCF) promotes collaborative innovation, measured by joint patents. Regression results reveal that SCF engagement doubles collaborative innovation output by alleviating financing constraints, optimizing trust relationships, …

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Selinexor in combination with azacitidine or Ruxolitinib for Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes: A Multi-Center Prospective Exploratory Study

Xijuan Lin, Ziwei Liu, Chen Yang, Junling Zhuang et autres

Abstract Abstract Background: Current therapeutic strategies for Myelodysplastic/Myeloproliferative Neoplasms overlap syndromes (MDS/MPN) remain suboptimal. Selinexor, an innovative oral selective inhibitor of exportin 1, presents a promising mechanism-based therapeutic approach. Both preclinical and clinical evidence suggest synergistic antileukemic effects when selinexor used in …

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Treatment with sirolimus for refractory/relapsed primary or secondary warm autoimmune hemolytic anemia/evans syndrome: A single centre prospective study

Qi Wang, Miao Chen, Junling Zhuang, Chen Yang et autres

Abstract Background There are unmet needs for patients with warm antibody autoimmune haemolytic anaemia (wAIHA) and Evans syndrome (ES) who are refractory/relapsed to steroids or other second or third line therapies. Mammalian target of rapamycin(mTOR) inhibitor sirolimus has been demonstrated effective in …

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Assembling and Modeling Stacked Disordered Metasurfaces

Miao Chen, Amit Sharma, Johann Michler, Xavier Maeder et autres

Disordered metasurfaces offer unique properties unattainable with periodic or ordered metasurfaces, notably the absence of deterministic interference effects at specific wavelengths and angles. In this work, we introduce a lithography-free nanofabrication approach to realize cascaded disordered plasmonic metasurfaces with submicrometer total thickness. …

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Kuntai Capsules Improve Premature Ovarian Failure by Regulating AMPK-Mediated Autophagy

Xiaomin Ye, Miao Chen, Haofan Chen, Xinmiao Lin

BACKGROUND: Premature ovarian failure (POF) is a gynecological endocrine disorder with current treatments having limitations. Kuntai capsule (KTC), a traditional Chinese medicine formulation, is thought to be beneficial for POF, but its mechanism is unclear. Network pharmacology can help explore drug mechanisms. …

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Efficacy and safety of immunosuppressive therapy versus cyclosporine combined with avatrombopag in older adults with severe aplastic anemia: a multicenter prospective study

Leyu Wang, Lei Ye, Xin Zhao, Miao Chen et autres

This trial compared antithymocyte globulin (ATG) + cyclosporine A (CsA) + avatrombopag (AVA) and CsA + AVA in older adults with severe aplastic anemia (SAA). The patients were randomized to receive either ATG + CsA + AVA or CsA + AVA. Of …

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