Junfeng Wang

Abstract 1100: Epigenetic profiling identifies markers of aggressive cancer subtype using a targeted methylation-based multi-cancer early detection (MCED) blood test

Kezhong Chen, Jian Huang, Dahong Zhang, Shu Wang et autres

Abstract Background: Previous MCED studies have shown differences in detection performance across different aggressiveness cancer subtypes. However, the methylation profiles and ctDNA shedding patterns across different aggressiveness subtypes have not been analyzed. We systematically compared cell-free DNA (cfDNA) tumor fraction and methylation …

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Hierarchical wrinkle pattern drives tenogenic differentiation from human mesenchymal stem cells

J.W. Kim, So Nagashima, Junfeng Wang, Seishiro Matsubara et autres

Stem cells possess the unique abilities to self-renew and differentiate into various cell types, making them invaluable in tissue engineering and regenerative medicine. This study explores the behavior of human bone marrow-derived mesenchymal stem cells (hMSCs) on poly(dimethylsiloxane) (PDMS) substrates with hierarchical …

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Transmembrane association of DDR1 and DDR2 mediated by Leucine zipper motifs

F. Y. Huang, Yuzhe Li, Peng Zhang, Jinqian Li et autres

Discoidin domain receptors (DDRs) are single-pass transmembrane proteins belonging to receptor tyrosine kinases (RTKs) family, which are activated by collagen ligands with unusual slow, sustained kinetics, distinguishing them from canonical RTKs. While DDRs play critical roles in cell adhesion, differentiation, and cancer …

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Abstract 2169: TTK/PLK1 dual antagonist BAL0891 synergizes with pembrolizumab in a vascularized 3D tumor microenvironment model

Junfeng Wang, Min-Kyung Kang, Byungjun Lee, Delaney Donnelly et autres

Abstract Introduction: BAL0891, a first-in-class dual TTK/PLK1 inhibitor, activates the cGAS/STING pathway and induces a senescence-associated secretory phenotype (SASP), resulting in increased PD-L1 expression and pro-inflammatory cytokine production in cancer cells. These changes enhance tumor susceptibility to immunotherapies. However, evaluating the synergy …

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Crosstalk between T lymphocyte and extracellular matrix in tumor microenvironment

Die Lv, Yujie Fei, Hongli Chen, Junfeng Wang et autres

The extracellular matrix (ECM) is a complex three-dimensional structure composed of proteins, glycans, and proteoglycans, constituting a critical component of the tumor microenvironment. Complex interactions among immune cells, extracellular matrix, and tumor cells promote tumor development and metastasis, consequently influencing therapeutic efficacy. …

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Observation of Intramural Tension Changes in Response to Contraction of Smooth Muscle Cells in the Aortic Walls of Mice Expressing FRET tension sensor

Yiming Hou, Junfeng Wang, Jeonghyun Kim, Eijiro MAEDA et autres

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Clinical characteristics and prognosis of non-small cell lung cancer patients with liver metastasis: A population-based study

Junfeng Wang, Hong-Di Lu, Ying Wang, Rui Zhang et autres

BACKGROUND: The presence of liver metastasis (LM) is an independent prognostic factor for shorter survival in non-small cell lung cancer (NSCLC) patients. The median overall survival of patients with involvement of the liver is less than 5 mo. At present, identifying prognostic …

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An independent poor-prognosis subtype of hepatocellular carcinoma based on the tumor microenvironment

Junfeng Wang, Jianying Lou, Lei Fu, Jin Qu

BACKGROUND: Hepatocellular carcinoma (HCC) is a highly malignant tumor with a particularly poor prognosis. The tumor microenvironment (TME) is closely associated with tumorigenesis, progression, and treatment. However, the relationship between TME genes and HCC patient prognosis is poorly understood. METHODS: In this …

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Long noncoding RNA LINC01578 drives colon cancer metastasis through a positive feedback loop with the NF‐κB/YY1 axis

Jia Liu, Jiefu Wang, Junfeng Wang, Jiansheng Guo et autres

Metastasis accounts for poor prognosis of cancers and related deaths. Accumulating evidence has shown that long noncoding RNAs (lncRNAs) play critical roles in several types of cancer. However, which lncRNAs contribute to metastasis of colon cancer is still largely unknown. In this …

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Effects of cyclic stretch on morphology of nucleus and actin filament of smooth muscle cells in cultured rabbit thoracic aortas

Junfeng Wang, Eijiro MAEDA, Takeo MATSUMOTΟ

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CUTL1 induces epithelial-mesenchymal transition in non-small cell lung cancer

Junfeng Wang, Yanbo Wang, Dawei Sun, Fenghai Ren et autres

The homeobox transcription factor CUTL1 has been associated with cellular proliferation and cell cycle progression, and CUTL1 functions as an oncogene. The aim of the present study was to investigate whether CUTL1 participates in epithelial-mesenchymal transition (EMT). The expression levels of CUTL1, …

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Conditional survival (CS) of metastatic renal cell carcinoma (mRCC) patients treated with high dose interleukin-2 (HD IL-2).

Kinjal J. Parikh, David Dean Stenehjem, Arun Sendilnathan, Hilda T. Crispin et autres

460 Background: CS is a clinically useful prediction measure that adjusts prognosis of patients on the basis of survival since treatment initiation or therapy duration. CS was recently reported in mRCC patients treated with VEGF targeted therapy in patients stratified by Heng’s …

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