Jeonghyun Kim

Rotating strain field: Development of a novel mechanical stimulation device and orthogonal alignment of MC3T3-E1 cells in response to anisotropic stimulation

Naoyuki J. Kawai, Junfeng Wang, Xinlu CHEN, Takatoshi IWAI et autres

Cyclic deformation of cell culture substrates induces various cellular responses, including alignment and cytoskeletal remodeling. However, most studies have focused on deformation in a fixed direction, which does not adequately replicate the complexity of in vivo mechanical environments. In this study, we …

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Impacts of submarine groundwater discharge on nutrient variations and diatom species dominance in a brackish pond

Yejin Park, Jeonghyun Kim, Soojin Kang, Yebin Jeon et autres

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Macroscopic and microscopic biomechanical analysis of mineralized spheroids derived by mesenchymal stem cells

Takashi Inagaki, Jeonghyun Kim, Eijiro MAEDA, Taiji ADACHI et autres

Three-dimensional cultures that simulate bone formation in vitro are promising approaches for elucidating the mineralization process involved in osteogenesis. In this study, we performed a multiscale analysis of spheroids derived from human mesenchymal stem cells. We quantified morphological changes and mechanical conditions …

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Structural characterization of newt tendon regeneration after complete transection: In vivo two‐photon imaging and transmission electron microscopy

Tomoaki Kamiya, Yusaku Ito, Tomohito Iwasaki, Daisuke Suzuki et autres

Mammalian tendons, including human tendons, possess limited regeneration capability, and its healing results in scar tissue formation. However, it was recently shown that tendons of newts, amphibians that exhibit regeneration capacity in various tissues and organs, achieve full regeneration, structurally and functionally, …

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HateBuffer: Safeguarding Content Moderators' Mental Well-Being through Hate Speech Content Modification

Subin Park, Jeonghyun Kim, Jeanne Choi, Joseph Seering et autres

Hate speech remains a persistent and unresolved challenge in online platforms. Content moderators, working on the front lines to review user-generated content and shield viewers from hate speech, often find themselves unprotected from the mental burden as they continuously engage with offensive …

Orthogonal alignment of multilayered MC3T3-E1 cells induced by cyclic stretch

Shuichiro Suzuki, Ken Imajo, Junfeng Wang, Jeonghyun Kim et autres

When cyclic stretch is applied to a monolayer of cells cultured on an elastic substrate, many types of cells align in the direction perpendicular to the stretch or along the direction of minimal substrate strain. However, the behavior of multilayer cells under …

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An osteoblast-like cell line derived from mice expressing FRET-based tension sensor reveals cellular tension increase during osteogenic differentiation

J. Y. Wang, Jeonghyun Kim, Eijiro MAEDA, Takeo MATSUMOTΟ

Mechanical stimuli significantly influence bone remodeling, although the detailed molecular mechanisms involving changes in intracellular tension during osteoblast differentiation remain unclear. The present study was performed to investigate the role of intracellular tension in osteogenic differentiation by utilizing a newly established osteoblast-like …

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Inhibitory effects of kukoamine B on adipogenesis and lipid accumulation in vitro and obesity in vivo

Kang-Il Oh, Jeonghyun Kim, Junhwan Jeong, Mun Hyoung Bae et autres

Obesity, characterized by excessive adipose tissue accumulation, is an important risk factor for the development of several chronic conditions, including cardiovascular disease, type 2 diabetes mellitus, and hypertension. The present study aimed to investigate the effects of kukoamine B (KB), a major …

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Quasi-static and dynamic mechanical properties of artificial tissue fabricated from concentrated collagen using mechano-chemical treatment

Takashi Suzuki, Tomohito Iwasaki, Keita Goto, Jeonghyun Kim et autres

The present study sought to develop artificial tissues possessing mechanical properties similar to those of human tendons. Collagen solution, concentrated via dialysis, was used to form a collagen gel . The gel was then subjected to mechano-chemical treatment, applying a 20-g static …

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Biomechanical properties of regenerated digital flexor tendon in immature newt following complete transection

Yu Masuda-Otsuka, Tomoaki Kamiya, Daisuke Suzuki, Toshinori Hayashi et autres

BackgroundAdult newt (9-month-old) has become an emerging research model to study complete regeneration of injured adult tendon. If younger newts exhibit tendon regeneration similar to adult ones, they can be used as an additional experimental model, assuring a high- throughput of experiments …

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Microscopic Strain Field Analysis of Newt Digital Flexor Tendon During Regeneration Following Complete Transection

Soki AOSHIMA, Toshinori Hayashi, Daisuke SUZUKI, Jeonghyun Kim et autres

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Multi-scale Observation of Cellular Tensional Homeostatic Responses in Tendon Fascicle

Yuki FURUNISHI, Junfeng WANG, Jeonghyun Kim, Takeo MATSUMOTO et autres

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