Timothy C. Wang

Bcl-xL Promotes Gastric Tumorigenesis via Apoptosis-Independent Wnt/β-Catenin Activation and PPARγ Suppression

Yukiko Oya, Junya Arai, Yoku Hayakawa, T. Shiokawa et autres

BACKGROUND AND AIMS: The Wnt/β-catenin and YAP pathways cooperatively drive gastrointestinal tumor progression. BCL2L1, a YAP target gene, encodes the anti-apoptotic isoform Bcl-xL, which is highly expressed in multiple cancers, but its role in gastric cancer remains unclear. METHODS: mice to study …

jp, us (code pays fourni par la source)

Endocrine–Neural Interactions Regulate Antral CCK2R⁺ Stem Cells in Gastric Inflammation and Preneoplasia

Biyun Zheng, Hualong Zheng, Ruhong Tu, Fenglin Chen et autres

SUMMARY Antral CCK2R⁺ stem cells are regulated by gastrin, but how endocrine and neural cues integrate under chronic injury remains unclear. Here we show that inducible hypogastrinemia shifts from asymmetric renewal to symmetric expansion of CCK2R⁺ stem cells. With carcinogenic stress, these …

cn, us (code pays fourni par la source)

Editor’s Note: Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

Bernhard W. Renz, Takayuki Tanaka, Masaki Sunagawa, Ryota Takahashi et autres

us (code pays fourni par la source)

Viral mimicry acts as a tumor suppressor in colitis

Frederikke Larsen, Will Jeong, Daniel Schep, Hayley Good et autres

Transposable elements (TEs) comprising nearly 50% of the genome are generally silenced by epigenetic mechanisms. Epigenetic anti-cancer drugs can lead to their re-expression, however, the role of TEs in tumorigenesis is unknown. Here, we demonstrate that TEs and their activation of a …

ca, us (code pays fourni par la source)

Entangled cellular and molecular relationships at the sensory neuron-cancer interface

Debpali Sur, Yi Zeng, Hiroki Kobayashi, Xiaofei Zhi et autres

Translational studies on pancreatic cancer and gastric cancer: a methodology in PhD thesis

Mathilde Resell, Gunnar Qvigstad, Timothy C. Wang, Anne S. Quante et autres

Pancreatic ductal adenocarcinoma (PDAC) and gastric adenocarcinoma (GA) are aggressive cancers with poor prognoses, demanding innovative approaches to advance treatment strategies and prevention efforts. This article presents a methodology in connection with PhD thesis on PDAC and GA, including motivation and knowledge …

no, us, de, es (code pays fourni par la source)

488: GASTRIN-DEPENDENT REGULATION OF MOUSE ANTRUM CCK2R+ STEM CELLS IN GASTRIC ATROPHY AND CANCER INITIATION

Biyun Zheng, Ru‐Hong Tu, Guodong Lian, Hiroki Kobayashi et autres

548: TFF2 MARKS GASTRIC CORPUS PROGENITORS THAT GIVE RISE TO PYLORIC METAPLASIA/SPEM FOLLOWING INJURY

Ru‐Hong Tu, Biyun Zheng, Jin Qian, Feijing Wu et autres

176: VAGAL SENSORY NEURONS REGULATE GASTRIC INFLAMMATORY MEMORY VIA CGRP/RAMP1 INTERACTION WITH STEM CELLS

Yi Zeng, Ruhong Tu, Feijing Wu, Xiaofei Zhi et autres

Abstract 3445: Germline BRCA2 heterozygosity drives gastric lesion formation via myeloid-biased differentiation in bone marrow under chronic IL-1β overexpression and Helicobacter felis infection

Feijing Wu, Quin T. Waterbury, Puran Zhang, Hiroki Kobayashi et autres

Background: BRCA2 plays a crucial role in DNA homologous recombination repair, and mutations in this gene significantly increase cancer risk. Previous studies have shown that heterozygous mutations in BRCA2 enhance pancreatic tumorigenesis driven by KRASG12D, but their impact on gastric tissues is …

us (code pays fourni par la source)

Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury

Ru‐Hong Tu, Biyun Zheng, Qing Zhong, Jin Qian et autres

Abstract In Brief Tu et al. show that Tff2 + corpus isthmus cells are TA progenitors, and they, not chief cells, are the primary source of SPEM following injury. Upon Kras mutation, these progenitors directly progress to dysplasia, bypassing metaplasia, highlighting them …

cn, us, jp (code pays fourni par la source)

Knowledge Discovery in Datasets of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer

Mathilde Resell, Elisabeth Pimpisa Graarud, Hanne-Line Rabben, Animesh Sharma et autres

Abstract Knowledge discovery in databases (KDD) can contribute to translational research, also known as translational medicine, by bridging the gap between in vitro and in vivo studies and clinical applications. Here, we propose a ‘systems modeling’ workflow for KDD. This framework includes …

no, us (code pays fourni par la source)