Yukiko Oya

Bcl-xL Promotes Gastric Tumorigenesis via Apoptosis-Independent Wnt/β-Catenin Activation and PPARγ Suppression

Yukiko Oya, Junya Arai, Yoku Hayakawa, T. Shiokawa et autres

BACKGROUND AND AIMS: The Wnt/β-catenin and YAP pathways cooperatively drive gastrointestinal tumor progression. BCL2L1, a YAP target gene, encodes the anti-apoptotic isoform Bcl-xL, which is highly expressed in multiple cancers, but its role in gastric cancer remains unclear. METHODS: mice to study …

jp, us (code pays fourni par la source)

ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment

Junya Arai, Yoku Hayakawa, Nobumi Suzuki, Hiroto Kinoshita et autres

-mutated GCs and represents a promising therapeutic target.

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Muc6 -expressing gastric isthmus progenitors contribute to regeneration and metaplasia supported by myeloid-mesenchymal interactions

Junya Arai, Yusuke Iwata, Ayumu Tsubosaka, Hiroto Kinoshita et autres

Summary Gastric mucosal homeostasis is maintained by tissue-resident stem and progenitor cells residing in the isthmus region. Following mucosal injury, surviving cells contribute to regeneration, coinciding with characteristic pathological changes such as atrophic gastritis and metaplasia. To comprehensively understand the cellular dynamics …

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Safety and Effectiveness of Colonic Stenting for Ileocecal Valve Obstruction and Usefulness of Two-Step Strategy: Single-Center Retrospective Study

Gota Fujisawa, Rei Ishibashi, Shuntaro Yoshida, Ryo Kondo et autres

Background: Endoscopic self-expandable metallic stent (SEMS) placement is a widely accepted treatment for malignant left-sided colorectal obstruction (LSO) because of its lower invasiveness and quicker symptomatic relief compared to surgery. However, SEMS placement for ileocecal valve obstruction (ICVO) has not been established …

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Sustained Clinical Complete Response after Discontinuation of Trastuzumab-deruxetecan Due to Interstitial Pneumonia for HER2-positive Gastric Adenocarcinoma with Enteroblastic Differentiation (GAED)

Nobumi Suzuki, Nariaki Odawara, Gota Fujisawa, Rei Ishibashi et autres

Trastuzumab deruxtecan (T-DXd) has demonstrated remarkable efficacy as a third- or later-line chemotherapy for human epidermal growth factor receptor 2 (HER2)-positive advanced gastric and gastroesophageal junction adenocarcinomas. However, it may cause pneumonitis, and its efficacy in rare histologies such as gastric adenocarcinoma …

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Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target

Junya Arai, Yoku Hayakawa, Hiroaki Tateno, K. Murakami et autres

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Occupational accidental injury deaths in Tokyo and Chiba prefectures, Japan: A 10‐year study (2011–2020) of forensic institute evaluations

Rutsuko Yamaguchi, Yohsuke Makino, Suguru Torimitsu, Go Inokuchi et autres

Occupational accidental injury deaths (OAIDs) are a major social problem, and the analysis of individual cases is important for developing injury prevention measures. In this study, OAIDs with autopsies performed at forensic facilities in the metropolitan area of Japan (Tokyo and Chiba …

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Trends and Characteristics in Health Care-related Deaths Investigated through Medico-legal Autopsies after System Changes in Japan.

Rutsuko Yamaguchi, Yohsuke Makino, Go Inokuchi, Kenji Ishihara et autres

In Japan, a new cause-of-death investigation system and related new laws were enacted in the mid-2010s. These laws provided for an autopsy system for non-criminal unnatural deaths and a medical accident investigation system outside the criminal justice process for health care-related deaths. …

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胃癌におけるBclxlの役割

Yukiko Oya

日本における 2019 年の癌による死亡数で胃癌は 3 位であり、遠隔転移のある胃癌の 5

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Dysregulated Immune Responses by ASK1 Deficiency Alter Epithelial Progenitor Cell Fate and Accelerate Metaplasia Development during H. pylori Infection

Yoku Hayakawa, Yoshihiro Hirata, Masahiro Hata, Mayo Tsuboi et autres

The mechanism of H. pylori-induced atrophy and metaplasia has not been fully understood. Here, we demonstrate the novel role of Apoptosis signal-regulating kinase 1 (ASK1) and downstream MAPKs as a regulator of host immune responses and epithelial maintenance against H. pylori infection. …

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Tumor microenvironment in gastric cancers

Yukiko Oya, Yoku Hayakawa, Kazuhiko Koike

The tumor microenvironment favors the growth and expansion of cancer cells. Many cell types are involved in the tumor microenvironment such as inflammatory cells, fibroblasts, nerves, and vascular endothelial cells. These stromal cells contribute to tumor growth by releasing various molecules to …

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Sa1167 ADRENALINE-DEPENDENT IMMUNOLOGIC REPROGRAMMING IN ENDOTHELIAL CELLS REGULATES TUMOR IMMUNITY IN GASTRIC CANCERS

Yoku Hayakawa, Mayo Tsuboi, Masahiro Hata, Yukiko Oya et autres