Hayley Good

Viral mimicry acts as a tumor suppressor in colitis

Frederikke Larsen, Will Jeong, Daniel Schep, Hayley Good et autres

Transposable elements (TEs) comprising nearly 50% of the genome are generally silenced by epigenetic mechanisms. Epigenetic anti-cancer drugs can lead to their re-expression, however, the role of TEs in tumorigenesis is unknown. Here, we demonstrate that TEs and their activation of a …

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A Novel Combined Surgical and Interventional Radiology Vascular Reconstruction, With Stenting of Meso‐Rex Bypass, to Successfully Manage Recurrent Portal Venous Flow Obstruction Post Segmental Liver Transplant in a Pediatric Patient

Hayley Good, Vicky L. Ng, Asad Siddiqui, Blayne A. Sayed et autres

BACKGROUND: Portal vein complications can be difficult to manage in the context of challenging anatomy and porto-systemic collaterals. METHODS: This case illustrates a child with biliary atresia and associated laterality (situs inversus, polysplenia) features, who underwent segmental liver transplantation with portal venous …

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O-027 Beyond the cancer: twenty-year analysis of fertility preservation (FP) outcomes in young women with cancer (YWC)

Maya Sharon‐Weiner, A Kauffman, Samantha Yee, Hayley Good et autres

Abstract Study question To analyze the percentage of YWC who pursued 'active' (IVF ±PGTA/M, ovarian tissue cryopreservation) versus 'passive' (GnRHa) FP and their 20-year conception outcomes. Summary answer After FP consultation, most YWC pursued active FP. 23.1% returned to try to conceive. …

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924: COLITIS IS ASSOCIATED WITH ACTIVATION OF A VIRAL MIMICRY RESPONSE THAT INHIBITS COLONIC TUMORIGENESIS

Frederikke Larsen, Hayley Good, Alice E. Shin, Mathieu Derouet et autres

IP09-39 “ATYPICAL” PRESENTATION OF LOWER URINARY TRACT OBSTRUCTION: A CASE FOR HEIGHTENED LEVEL OF SUSPICION AND USE OF THE TORONTO NOMOGRAM

Juliane Richter, Hayley Good, Michael Chua, Jin K. Kim et autres

Successful ilio-femoral-popliteal venous aspiration thrombectomy using a 12 French system in a pediatric patient

Hayley Good, Dimitri A. Parra

Deep venous thrombosis can be observed in pediatric patients, especially in teenagers. There is a paucity of published treatment recommendations in this patient population. This technical note illustrates the successful utilization of aspiration thrombectomy to manage a lower extremity deep venous thrombosis …

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Prostaglandin E2 and Akt Promote Stemness in Apc Mutant Dclk1+ Cells to Give Rise to Colitis-associated Cancer

Hayley Good, Frederikke Larsen, Alice E. Shin, Liyue Zhang et autres

Background & Aims Loss of the tumor suppressor gene Apc in Lgr5+ intestinal stem cells results in aberrant Wnt signaling and colonic tumorigenesis. In the setting of injury, however, we and others have also shown that non-stem cells can give rise to …

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Use of prenatal ultrasound findings to predict postnatal outcome in fetuses with lower urinary tract obstruction

Juliane Richter, Shiri Shinar, Lauren Erdman, Hayley Good et autres

OBJECTIVE: Lower urinary tract obstruction (LUTO) is a chronic condition with a spectrum of outcomes. It is usually suspected prenatally based on ultrasound features (USFs). Given the unknown postnatal trajectory and the potential for significant morbidity and mortality, many families choose termination …

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1276 ACTIVATION OF A VIRAL MIMICRY RESPONSE INHIBITS COLITIS-ASSOCIATED CANCER

Frederikke Larsen, Hayley Good, Alice E. Shin, Liyue Zhang et autres

PD55-06 EARLY PRENATAL DETECTION OF LUTO IS ASSOCIATED WITH INCREASED RISK OF KIDNEY TRANSPLANTATION—A MULTI-INSTITUTIONAL TRANS-ATLANTIC EXPERIENCE

Franziska Juliane Richter, Luke Harper, Silvia Pecorelli, Massimo Garriboli et autres

You have accessJournal of UrologyPediatrics VI (PD55)1 May 2024PD55-06 EARLY PRENATAL DETECTION OF LUTO IS ASSOCIATED WITH INCREASED RISK OF KIDNEY TRANSPLANTATION—A MULTI-INSTITUTIONAL TRANS-ATLANTIC EXPERIENCE Franziska Juliane Richter, Luke Harper, Silvia Pecorelli, Massimo Garriboli, Giulia Lanfranchi, Hayley Good, Joana Dos Santos, Jin …

Early prenatal detection of LUTO is associated with increased risk of kidney transplantation - a multi-institutional trans-atlantic experience

Juliane Richter, Lorraine Harper, S. Pecorelli, Hayley Good et autres

A4 DNA HYPOMETHYLATION INHIBITS COLITIS-ASSOCIATED CANCER

Finn Ole Larsen, Hayley Good, Alice E. Shin, Mathieu Derouet et autres

Abstract Background Colorectal cancer is the second leading cause of cancer death in Canada. A major risk factor for the development of colorectal cancer is chronic inflammation leading to colitis-associated cancer (CAC). We previously described a CAC mouse model in which tumors …

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