Dazhi Guo

Polysaccharide of Danggui Buxue Decoction Attenuates Colorectal Cancer via Modulating Intestinal Microflora and Metabolites

Min Guo, Dazhi Guo, Jian-Nan Cao, Xiaodong Li et autres

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Single‐Cell RNA Sequencing and Spatial Transcriptomics Reveal a Novel Mechanism of Oligodendrocyte–Neuron Interaction in Cognitive Decline After High‐Altitude Cerebral Edema

Wenying Lv, Yuehong Ma, Dongtao Li, Kexin Xiong et autres

BACKGROUND: High-altitude cerebral edema (HACE) leads to cognitive decline, but the underlying cellular and molecular mechanisms remain unclear. METHODS: We established a mouse model of HACE under hypobaric hypoxia (simulating at an altitude of 6000 m) and analyzed hippocampal changes using single-cell …

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Altered Functional Connectivity in Acute Ischemic Post-Stroke Non-Fluent Aphasia Based on fMRI-EEG Multimodal Fusion

Jianxiu Wang, Lin Mao, Hang Zhou, Shuang Wei et autres

This study examined alterations in resting-state and task-state functional connectivity (FC) in patients with acute ischemic post-stroke nonfluent aphasia, using a combined resting-state functional magnetic resonance imaging and visuospatial working memory electroencephalography methodology. We recruited a case group (n =7) of patients …

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Dysfunction of the Gut-Brain-Axis in delayed encephalopathy after carbon monoxide poisoning

Kexin Xiong, Yuehong Ma, Wenying Lv, Dazhi Guo

Sub-acute stroke demonstrates altered beta oscillation and connectivity pattern in working memory

Lin Mao, Xianwei Che, Juehan Wang, Xiaorui Jiang et autres

INTRODUCTION: Working memory (WM) is suggested to play a pivotal role in relearning and neural restoration during stroke rehabilitation. Using EEG, this study investigated the oscillatory mechanisms of WM in subacute stroke. METHODS: This study included 48 first subacute stroke patients (26 …

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Single-Cell Rna Sequencing and Spatial Transcriptomics Reveal a Novel Mechanism of Oligodendrocyte–Neuron Interaction in Cognitive Decline after High-Altitude Cerebral Edema

Wenying Lv, Yuehong Ma, Dongtao Li, Kexin Xiong et autres

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Risk factors and Outcome Analysis of Delayed Neurological Sequelae in elderly patients with carbon monoxide poisoning

Yuehong Ma, Ruijun Xue, Huijun Hu, Shuyi Pan et autres

Abstract Objective Carbon monoxide (CO) poisoning is one of the common causes of poisoning in patients and can result in significant neurological sequelae. However, few studies have focused on the elderly population. Method We retrospectively reviewed elderly (age≥60 years) with CO poisoning …

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Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition

Pengxiang Zhao, Zheng Dang, Mengyu Liu, Dazhi Guo et autres

Abstract Background Despite progress in developing wound care strategies, there is currently no treatment that promotes the self-tissue repair capabilities. H2 has been shown to effectively protect cells and tissues from oxidative and inflammatory damage. While comprehensive effects and how H2 functions …

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Long-Term Lower Limb Motor Function Correlates with Middle Cerebellar Peduncle Structural Integrity in Sub-Acute Stroke: A ROI-Based MRI Cohort Study

Daming Wang, Lingyan Wang, Dazhi Guo, Shuyi Pan et autres

Crossed cerebellar diaschisis (CCD) has been widely investigated in patients with supratentorial stroke. However, the role of CCD in lower limb recovery after stroke is still unknown. In this study, using a region-of-interest-based analysis of diffusion tensor imaging (DTI), a total of …

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A Disintegrin and Metalloproteinase 10 (ADAM10) Is Essential for Oligodendrocyte Precursor Development and Myelination in the Mouse Brain

Dazhi Guo, Fei Huang, Ruijun Xue, Yuehong Ma et autres

Abstract A disintegrin and metalloproteinase 10 (ADAM10) plays an essential role in the regulation of survival, proliferation, migration, and differentiation of various neural cells. Nevertheless, the role of ADAM10 in oligodendrocyte precursors (OPCs) and myelination in the central nervous system (CNS) of …

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Effect of Hyperbaric oxygen on myelin injury and repair after hypoxic-ischemic brain damage in adult rat

Ruijun Xue, Shuyi Pan, Dazhi Guo

INTRODUCTION: Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of death and neurological disability with limited options for treatment in neonates, children and adults worldwide. The pathogenesis and treatment of white matter (WM) injury in adult patients with HIE remains largely …

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A disintegrin and metalloproteinase 10 (ADAM10) is essential for oligodendrocyte precursor development and myelination in the mouse brain

Dazhi Guo, Fei Huang, Ruijun Xue, Yuehong Ma et autres

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