Xiaoliang Wang

Observation of out-of-plane ferroelectricity in ∼5 nm ultrathin SrBi2Ta2O9 films for memristors and synapses application

Liping Tan, Xuefeng Hu, Aowen Li, Ming Zhou et autres

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Real-world treatment patterns and patient characteristics of venetoclax combination time-limited therapy for chronic lymphocytic leukemia

Jing-Zhou Hou, Rushir J. Choksi, Gregory A. Maglinte, Xiaoliang Wang et autres

Abstract Background The use of targeted therapies, such as combinations of anti-CD20 monoclonal antibodies and BCL2 inhibitors, is rapidly evolving in the treatment of chronic lymphocytic leukemia (CLL). Venetoclax plus obinutuzumab (VO) is approved as a first-line (1L) therapy with a fixed …

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Real-world chronic lymphocytic leukemia (CLL)–specific biomarker testing patterns and frontline treatment patterns in patients with CLL/small lymphocytic lymphoma (SLL)

Tim Reynolds, William Ye, Linda Chen, Mohammad Reza Eskandari et autres

Abstract Introduction: CLL/SLL is the most common leukemia in adults in the United States, with ~21,000 cases diagnosed annually. National Comprehensive Cancer Network (NCCN) guidelines recommend testing for certain prognostic variables prior to initiation of CLL/SLL treatment (tx). For patients (pts) with …

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S1122 Association Between SGLT2 Inhibitors and Irritable Bowel Syndrome and Gastrointestinal Symptoms in Non-Diabetic Patients With Chronic Kidney Disease or Heart Failure

Xiaoliang Wang, Jin‐Xiu Pan, Jiayan Wang, Yilin Song et autres

Introduction: Sodium–glucose cotransporter-2 inhibitors (SGLT2i) have emerged as key therapies for chronic kidney disease (CKD) and heart failure (HF), including in non-diabetic patients. In addition to their established glucose-lowering and renoprotective effects, SGLT2is exhibit anti-inflammatory and antioxidative properties. Gastrointestinal (GI) symptoms—such as …

Correction: Src inhibition attenuates neuroinflammation and protects dopaminergic neurons in Parkinson's disease models

Hanyu Yang, Lu Wang, Caixia Zang, Yue Wang et autres

and histone H3 were measured by western blot. Each bar represents the mean ± SEM. n = 4. # P < 0.05 and ## P < 0.01 vs. control group, * P < 0.05 vs. MPTP group.In the published article, there were …

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POSTER: CLL-411 Real-World Bruton Tyrosine Kinase Inhibitor Use and Clinical Outcomes Among Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Jing‐Zhou Hou, Gregory A. Maglinte, Xiaoliang Wang, Anupama Vasudevan et autres

CLL-411: Real-World Bruton Tyrosine Kinase Inhibitor Use and Clinical Outcomes Among Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Jing‐Zhou Hou, Gregory A. Maglinte, Xiaoliang Wang, Anupama Vasudevan et autres

Real-world Bruton tyrosine kinase inhibitor (BTKi) use and clinical outcomes among patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).

Jing‐Zhou Hou, Gregory A. Maglinte, Xiaoliang Wang, Anupama Vasudevan et autres

e23271 Background: BTKis are the standard of care for CLL/SLL in the first-line (1L) and relapsed/refractory (R/R) settings. The next-generation BTKi zanubrutinib (zanu) demonstrated superiority over the first-generation BTKi ibrutinib (ibr) in treating R/R CLL, while the second-generation BTKi acalabrutinib (acala) only …

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Heterogeneity of cardiometabolic and hepatic fibrosis risks in nonalcoholic fatty liver disease among lean, overweight, and obese populations: a multicenter cross-sectional study

Lili Gao, Wujun Xiong, Ying Wang, Weizong Wang et autres

OBJECTIVE: Given that cardiovascular events induced by metabolic disorders are the leading cause of death in nonalcoholic fatty liver disease (NAFLD), this study aimed to explore the heterogeneity of cardiometabolic and liver fibrosis risks among lean, overweight, and obese NAFLD individuals. METHODS: …

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Cell-Permeable Microprotein from Panax Ginseng Protects Against Doxorubicin-Induced Oxidative Stress and Cardiotoxicity

Bamaprasad Dutta, Shining Loo, Antony Kam, Xiaoliang Wang et autres

(1) Background: Doxorubicin (DOX) is a frontline chemotherapeutic, but its side-effects from oxidative stress, leading to cardiotoxicity, pose significant challenges to its clinical use. We recently discovered a novel family of proteolysis-resistant, cystine-dense, and cell-penetrating microproteins from Panax ginseng that we term …

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Observation of Out-of-Plane Ferroelectricity in ∼5 nm Ultrathin SrBi2Ta2O9 Films for Ferroelectric Tunnel-Junction Memristors and Synapses Application

Liping Tan, Xuefeng Hu, Aowen Li, Weiwei Qin et autres

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2-(4-Methylthiazol-5-yl) Ethyl Nitrate Hydrochloride Ameliorates Cognitive Impairment via Modulation of Oxidative Stress and Nuclear Factor Kappa B (NF-κB) Signaling Pathway in Chronic Cerebral Hypoperfusion-Associated Spontaneously Hypertensive Rats

Jiang Li, Shaofeng Xu, Ling Wang, Xiaoliang Wang

Hypertension reduces the bioavailability of vascular nitric oxide (NO) and contributes to the onset of vascular dementia (VaD). A loss of NO bioavailability increases inflammation and oxidative stress. 2-(4-Methylthiazol-5-yl) ethyl nitrate hydrochloride (W1302) is a novel nitric oxide donor (NOD) which is …

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