Na Li

Clinical effectiveness and safety of total glucosides of paeony as an immunomodulator in patients with refractory oral lichen planus: A multicenter, pragmatic, randomized controlled trial

Yiwen Deng, Leilei Zhou, Na Li, Fan Huang et autres

cn (code pays fourni par la source)

a1-antitrypsin, a new biomarker of polycystic ovary syndrome by changing its expression and rhythm

Na Li, Beilei Shen, Wei Cao, Rourou Chen et autres

BACKGROUND: Previous proteomic studies have demonstrated the potential for identifying specific diagnostic biomarkers in the plasma and follicular fluid of patients with polycystic ovary syndrome (PCOS), which was utilized to elucidate the underlying etiology of PCOS. Our study aimed to identify differences …

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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

Yan Sun, Xiuna Yang, Shuangshuang Yang, Yizhu Lyu et autres

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding receptor activation, and facilitating amplification of signal transduction across the cellular membrane. However, cell-surface antigen-induced multimerization (dubbed AIM herein) has not yet been consciously leveraged in chimeric antigen …

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Identification and functional validation of FZD8-specific antibodies

Na Li, Qiangqiang Ge, Qiong Guo, Yuyong Tao

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As Fast As We Can: Rational Design of Rapid Chimeric Antigen Receptor T Cell Manufacturing

Pengfei Jiang, Shih-Ting Cao, Haiying Wang, Qinghui Xiong et autres

Background Chimeric antigen receptor T cell proved to be a promising approach to treat hematological malignancies. There are six autologous CAR-T drugs approved by FDA in US. The production of autologous CAR-T cells is carried out by a time-consuming manufacture process typically …

Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR

Angela Q. Zhang, Alexander Hostetler, Laura E. Chen, Vainavi Mukkamala et autres

The effectiveness of chimaeric antigen receptor (CAR) T cell therapies for solid tumours is hindered by difficulties in the selection of an effective target antigen, owing to the heterogeneous expression of tumour antigens and to target antigen expression in healthy tissues. Here …

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Data from Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

Xiaojun Liu, Shuguang Jiang, Chongyun Fang, Shiyu Yang et autres

Abstract Target-mediated toxicity is a major limitation in the development of chimeric antigen T-cell receptors (CAR) for adoptive cell therapy of solid tumors. In this study, we developed a strategy to adjust the affinities of the scFv component of CAR to discriminate …

Data from Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

Xiaojun Liu, Shuguang Jiang, Chongyun Fang, Shiyu Yang et autres

Abstract Target-mediated toxicity is a major limitation in the development of chimeric antigen T-cell receptors (CAR) for adoptive cell therapy of solid tumors. In this study, we developed a strategy to adjust the affinities of the scFv component of CAR to discriminate …

Microstructural changes of white matter assessed with diffusional kurtosis imaging in extremely preterm infants with severe intraventricular hemorrhage

Limin Guo, Meng Zhao, Yue Cai, Na Li et autres

Objective Intraventricular hemorrhage (IVH) is a serious neurological complication in premature infants. This study aimed to investigate the white matter impairments and neurodevelopmental outcomes of severe IVH in extremely preterm infants with gestation age less than 28 weeks. Methods We retrospectively evaluated …

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Eradication of tumors with pre-existing antigenic heterogeneity by vaccine-mediated co-engagement of CAR T and endogenous T-cells

Leyuan Ma, Duncan M. Morgan, Ina Sulkaj, Parisa Yousefpour et autres

Abstract Chimeric Antigen Receptor (CAR) T-cell therapy can be effective in treating human cancer but loss of the antigen recognized by the CAR poses a major obstacle. Here, we report an approach for vaccine boosting CAR T-cells, which triggers engagement of the …

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Long non-coding RNA growth arrest specific 5 is downregulated in sepsis-ALI and inhibits apoptosis by up-regulating miR-146a

Jiaqiong Li, Hongyang Xu, Na Li, Wenjing Du et autres

Long non-coding RNA (lncRNA) growth arrest specific 5 (GAS5) and microRNA (miR)-146a both have inhibitory effects on LPS-induced inflammation, suggesting the crosstalk between them. In this study, the expression of GAS5 and miR-146a in patients with sepsis-induced acute lung injury (sepsis-ALI), sepsis …

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Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma

Luan Sun, Fang Gao, Zhanhui Gao, Lei Ao et autres

BACKGROUND: Glypican-3 (GPC3), a cell surface glycoprotein that is pathologically highly expressed in hepatocellular carcinoma (HCC), is an attractive target for immunotherapies, including chimeric antigen receptor (CAR) T cells. The serum GPC3 is frequently elevated in HCC patients due to the shedding …

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