Xin Li

Data from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Abstract Immunosuppressive myeloid cells are critical obstacles to T cell–centered immune checkpoint blockade therapies, which have been successful in treating a fraction of patients with cancer. How tumor cells interact with myeloid cells to regulate immune responses and tumor development is unclear. …

Figure S6 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Fig. S6. EphB1 expression on tumor cells promotes T cell exhaustion in LILRB5 transgenic mice.

Figure S1 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Fig. S1. Eph receptors do not bind to LILRB1, LILRB3, LILRB4 and LAIR1.

Figure S4 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Fig. S4. Myeloid specific transgenic mice of LILRB5.

Visualization of intracellular ice formation and growth in mouse oocytes

Xin Li, Shuyong Zhang, Yuqi Zhang, Xinli Zhou

BACKGROUND: Characterization of intracellular ice formation (IIF) in oocytes during the freezing and thawing processes will contribute to optimizing their cryopreservation. However, the observation of the ice formation process in oocytes is limited by the spatiotemporal resolution of the cryomicroscope systems. OBJECTIVE: …

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Visualization of Ice Crystal Behavior in Mouse Oocytes During High-Speed Quench Cooling and Ice Inhibition by Antifreezing Hydrogels

Xin Li, Shuyong Zhang, Yuqi Zhang, Xinli Zhou

Oocyte vitrification has become a widely adopted method in clinical practice. However, the solidification behavior and its impact on oocytes during the ultrarapid cooling process remain poorly understood. In this study, we established a system and methodology to observe crystallization behavior in …

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Effects of Chinese herbal feed additives on the sperm quality and reproductive capacity in breeding boars

Weilong Tu, Weiyi Zhang, Hongyang Wang, Yingying Zhang et autres

Currently, Chinese herbal feed additives (CHFA) are commonly utilized in domestic pig farms. However, their impact on the sperm quality and reproductive capacity of imported breeding boars has yet to be thoroughly explored. In this study, the effect of CHFA on the …

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Effectiveness and safety assessment of drospirenone/ethinyl estradiol tablet in treatment of PCOS patients: a single center, prospective, observational study

Li Li, Ruiqin Zhang, Jing Zeng, Ke Hu et autres

BACKGROUND: To investigate the effectiveness and safety of 3 mg drospirenone and 20 μg ethinyl estradiol tablet (3 mg DRSP/20 μg EE) in the treatment of polycystic ovary syndrome (PCOS). METHODS: This single center, prospective observational study was conducted in 140 patients …

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Differential Expression Patterns of Glycolytic Enzymes and Mitochondria-Dependent Apoptosis in PCOS Patients with Endometrial Hyperplasia, an Early Hallmark of Endometrial Cancer, In Vivo and the Impact of Metformin In Vitro

Tao Wang, Jiao Zhang, Min Hu, Yuehui Zhang et autres

The underlying mechanisms of polycystic ovarian syndrome (PCOS)-induced endometrial dysfunction are not fully understood, and although accumulating evidence shows that the use of metformin has beneficial effects in PCOS patients, the precise regulatory mechanisms of metformin on endometrial function under PCOS conditions …

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Endometrial progesterone receptor isoforms in women with polycystic ovary syndrome.

Min Hu, Juan Li, Yuehui Zhang, Xin Li et autres

CONTEXT: Polycystic ovary syndrome (PCOS) affects approximately 4%-18% of all reproductive-aged women and is often accompanied by endometrial progesterone (P4) resistance. Endometrial cells from PCOS patients display increased progesterone receptor (PGR) expression; however, in vivo knockout studies and in vitro experiments indicate …

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Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome

Yuehui Zhang, Min Hu, Fanci Meng, Xiaoyan Sun et autres

Adult rats treated concomitantly with insulin and human chorionic gonadotropin exhibit endocrine, metabolic, and reproductive abnormalities that are very similar to those observed in polycystic ovary syndrome (PCOS) patients. In this study, we used this rat model to assess the effects of …

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Molecular characterization of insulin resistance and glycolytic metabolism in the rat uterus

Yuehui Zhang, Xue Sun, Xiaoyan Sun, Fanci Meng et autres

Peripheral insulin resistance and hyperandrogenism are the primary features of polycystic ovary syndrome (PCOS). However, how insulin resistance and hyperandrogenism affect uterine function and contribute to the pathogenesis of PCOS are open questions. We treated rats with insulin alone or in combination …

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