Hoon Kim

RAF1 extrachromosomal DNA amplification confers acquired erlotinib resistance in a non-small cell lung cancer cell model

Sujin Kim, Boyoon Kim, Ahjin Lim, Hoon Kim et autres

EGFR (epidermal growth factor receptor)-targeted therapies, which utilize small molecule inhibitors such as erlotinib and osimertinib to inhibit aberrantly activated EGF receptors caused by oncogenic mutations such as L858R and exon 19 deletion occurring primarily in the region coding its kinase domain, …

kr (code pays fourni par la source)

IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation

Jung Won Park, Jiehoon Kwak, Keon Woo Kim, ST Jung et autres

Identifying the cell of origin that harbors an initial driver mutation is key to understanding tumor evolution and for the development of new treatments. For isocitrate dehydrogenase (IDH)–mutant gliomas, the most common malignant primary brain tumor in young adults, the cell of …

kr, jp, de (code pays fourni par la source)

Extrachromosomal DNA amplifications exhibit distinct molecular characteristics and prognostic implications in gastric cancer

So-Young Kang, Donghyeok Seol, J.L. Lee, Chanmi Bang et autres

Gastric cancer (GC) is characterized by marked molecular heterogeneity that contributes to differential patient outcomes. Focal amplification in form of extrachromosomal DNA (ecDNA) is common in multiple cancer types and is associated with poor patient outcomes, but its prevalence and clinical implications …

kr, us (code pays fourni par la source)

Discovering Molecular Signatures in ATMR: Single-Cell RNA-Sequencing Analysis of Human Blood and Tissue Spatial Transcriptomics

Young Hwan Kim, Jie Song, Mijeong Kang, Hoon Kim et autres

Purpose: Acute T cell-mediated rejection (ATMR) is one of the most important causes of kidney graft injury and loss, yet in-depth transcriptomic analyses of relevant tissues and circulating immune cells are limited.

kr, Éthiopie (code pays fourni par la source)

Spatial and genomic profiling of residual breast cancer after neoadjuvant chemotherapy unveil divergent fates for each breast cancer subtype

Eun Seop Seo, Sabin Park, Eun Yoon Cho, Jeong Eon Lee et autres

Residual cancer burden (RCB) is a strong prognostic marker after neoadjuvant chemotherapy (NAC) in breast cancer (BC), yet some BCs defy their predicted outcomes. Using single-cell spatial transcriptomics and genomic profiling, we investigate mechanisms underlying divergent fates of BCs with high RCB …

kr (code pays fourni par la source)

Abstract 3755: AmpliconSuite enables discovery of extrachromosomal DNA in tumor genomes

Jens Luebeck, Edwin P. Huang, Ted Liefeld, Forrest Kim et autres

Abstract Focal amplifications in the cancer genome, particularly extrachromosomal DNA (ecDNA) amplifications, are a pivotal event in cancer progression across diverse cancer contexts. These megabase-scale circular structures arise when DNA breaks off chromosomes, accumulating hundreds of copies per cell through asymmetric segregation …

us, gb, kr, pt (code pays fourni par la source)

STEM-04. UNVEILING GLIOBLASTOMA ORIGIN-CELLS: ISOLATION AND CHARACTERIZATION FROM THE SUBVENTRICULAR ZONE

Ran Joo Choi, Se-Young Jo, Eunchae Yeo, Hyeong-Cheol Oh et autres

Abstract Glioblastoma (GBM) may originate from somatic mutations within the subventricular zone (SVZ). We investigated putative GBM origin-cells in the SVZ with somatic mutations implicated in GBM development. We hypothesized these origin-cells have unique properties compared to tumor-derived GBM tumorspheres (TSs). We …

kr (code pays fourni par la source)

Mapping extrachromosomal DNA amplifications during cancer progression

Hoon Kim, Soyeon Kim, Taylor E. Wade, Eunchae Yeo et autres

To understand the role of extrachromosomal DNA (ecDNA) amplifications in cancer progression, we detected and classified focal amplifications in 8,060 newly diagnosed primary cancers, untreated metastases and heavily pretreated tumors. The ecDNAs were detected at significantly higher frequency in untreated metastatic and …

kr, us, lu, nl (code pays fourni par la source)

13. AmpliconSuite: Analyzing focal amplifications in cancer genomes

Jens Luebeck, Edwin P. Huang, Bhargavi Dameracharla, Forrest Kim et autres

us, kr, gb, pt (code pays fourni par la source)

PCSK9 Inhibitors and Infection-Related Adverse Events: A Pharmacovigilance Study Using the World Health Organization VigiBase

Dahyun Park, Sungho Bea, Ji-Hwan Bae, Hyesung Lee et autres

AIMS: Protein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are novel lipid-lowering agents used in patients with cardiovascular disease. Despite reassuring safety data from pivotal trials, increasing evidence from real-world studies suggests that PCSK9i increase the risk of bacterial and viral infections. Therefore, …

kr (code pays fourni par la source)

AmpliconSuite: an end-to-end workflow for analyzing focal amplifications in cancer genomes

Jens Luebeck, E.-S. Huang, Forrest Kim, Ted Liefeld et autres

ABSTRACT Focal amplifications in the cancer genome, particularly extrachromosomal DNA (ecDNA) amplifications, are emerging as a pivotal event in cancer progression across diverse cancer contexts, presenting a paradigm shift in our understanding of tumor dynamics. Simultaneously, identification of the various modes of …

us, gb, de, kr, pt (code pays fourni par la source)

Abstract 4346: Deciphering the landscape of extrachromosomal DNA in gastric cancer and its potential impact on cancer dynamics

Donghyeok Seol, Seunghyun Kang, Sang‐Hyun Kim, Jieun Lee et autres

Abstract Extrachromosomal DNA (ecDNA) drives substantial copy number increases in focal regions harboring oncogenes and its non-Mendelian inheritance during mitosis contributes to cancer heterogeneity and a poor prognosis across multiple cancer types. However, the prevalence and function of ecDNA in gastric cancer …

kr (code pays fourni par la source)