Peng Liu

KAT2A upregulates the Tfrc/Hmox1-mediated ferroptosis pathway to disrupt neovascular structure and impair healing function in Fibroblasts under high-glucose conditions

Zhuofei Zhang, Yuzhi Wang, Peng Liu, Yunqing Dong et autres

Background Diabetic foot ulcer (DFUs) is a serious complication related to diabetes, which is caused by long-term inflammation, increased blood sugar levels and wound healing disorders caused by fibroblast dysfunction. The dysfunction of fibroblasts in DFU wounds, especially the loss of function …

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Identification of ferroptosis-related therapeutic targets and causal risk factors in aortic dissection via multi-omics integration

Shaoyi Peng, Peng Liu, Kaiyuan Li

The role of ferroptosis in the pathogenesis of aortic dissection (AD) has not been fully clarified. Data from the gene expression omnibus database were analyzed to identify differentially expressed ferroptosis-related genes (FRGs) in AD. Key FRGs were selected using Least Absolute Shrinkage …

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Swim Exercise Mitigates BCAA ‐Induced Atrial Remodeling and AF Susceptibility via Inhibition of Bax‐Mediated Mitochondrial Apoptosis

Haoyu Gong, Lingyan Jin, Yudi Zhang, Lulu Gong et autres

Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, has been shown in our prior work to be mitigated by swim exercise. While accumulating evidence links elevated circulating branched-chain amino acids (BCAA) to cardiovascular disease, their specific involvement in AF pathogenesis and …

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Association of perchlorate, nitrate, and thiocyanate with age-related macular degeneration in the United States

Qin Liu, Peng Liu, Shanshan Li

Perchlorate, nitrate, and thiocyanate are endocrine-disrupting chemicals, but their associations with AMD is unclear. This study aims to investigate this relationship. We included 4727 participants aged 40 years and older from the National Health and Nutrition Examination Survey (NHANES) 2005-2008. Logistic regression …

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Exploring the potential causal association between oral microbiota and heart failure using Mendelian randomization in an East Asian population

Shaoyi Peng, Kaiyuan Li, Peng Liu, Lei Wang et autres

Growing evidence suggests that the gut microbiota is closely associated with the risk of developing heart failure (HF). However, the potential impact of oral microbiota on HF has received far less attention. Using instrumental variable from the latest genome-wide association study data …

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MPAC: a computational framework for inferring pathway activities from multi-omic data

Peng Liu, David L. Page, Paul Ahlquist, Irene M. Ong et autres

MOTIVATION: Fully capturing cellular state requires examining genomic, epigenomic, transcriptomic, proteomic, and other assays for a biological sample and comprehensive computational modeling to reason with the complex and sometimes conflicting measurements. Modeling these so-called multi-omic data is especially beneficial in disease analysis, …

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Global, regional, and national burden of atrial fibrillation and flutter associated with metabolic risk factors, 1990–2021

Lu Wang, Xinghua Qin, Linyan Jin, Haoyu Gong et autres

Objectives: Atrial fibrillation/flutter (AF/AFL) is increasingly correlated with metabolic risk factors. This study analyzed mortality, disability-adjusted life years (DALYs), annual percentage changes (APCs), and estimated annual percentage changes (EAPCs), stratified by age, sex, Socio-demographic Index (SDI), and region, to evaluate the global …

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Bromodomain and Extraterminal Protein Inhibition: A Novel Therapeutic Strategy in Arthritis

Weibei Sheng, Jin Xia Zhao, Fei Yu, Deli Wang et autres

Arthritis is an inflammatory condition that affects the joints and surrounding tissues, triggered by factors such as inflammation, infection, degeneration, and trauma. The major forms of arthritis include osteoarthritis (OA), rheumatoid arthritis (RA), and gouty arthritis (GA). Its pathogenesis primarily involves synovial …

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Dendritic cell-based vaccine prepared with recombinant Lactococcus lactis eukaryotic-prokaryotic dual expressing OVA enhances antitumor efficacy by both direct and cross-presentation

Tingting Zhang, Shuai Huang, Peng Liu, Xia Su et autres

Probiotic Lactococcus lactis ( L.L ) can act as an antigen delivery carrier to cross-present (XPT) exogenous antigens in dendritic cells (DCs). To optimize antigen XPT in a DC-based vaccine for improved antitumor efficacy, we produced recombinant L.L strains expressing the model …

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Mycobacterium tuberculosis Hsp70 as a cancer vaccine adjuvant: Immunomodulatory mechanisms and tumor microenvironment remodeling

Peng Liu, Zunmeng Sang, Kangkang Liu, Minghao Zhang et autres

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The role of post-translational modifications in parvovirus life cycle

Peng Liu, Li-Qin Yang

Parvoviruses are a group of single-stranded DNA viruses that lack an envelope and are widely distributed in both vertebrates and invertebrates. When they infect a host cell, parvoviruses take over the cell's translational machinery to support the viral genome replication and proteins …

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Transmembrane mucins in lung adenocarcinoma: understanding of current molecular mechanisms and clinical applications

Xiaoqing Li, Ying Chen, Rui Lan, Peng Liu et autres

The mucin family is a group of highly glycosylated macromolecules widely present in human epithelial cells and with subtypes of secreted and membrane-associated forms. The membrane-associated mucins, known as transmembrane mucins, are not only involved in the formation of mucus barrier but …

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