Lingyan Jin

Rapamycin attenuates age-related atrial remodeling and fibrillation by targeting HIF-1α-mediated metabolic dysregulation

Lingyan Jin, 蒋田南, Haoyu Gong, Lulu Gong et autres

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Hyperactivation of autophagy contributes to high-intensity exercise-induced atrial fibrillation by activating cardiac necroptosis and inflammatory responses

Yuping Fu, Lingyan Jin, Yudi Zhang, Haoyu Gong et autres

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Swim Exercise Mitigates BCAA ‐Induced Atrial Remodeling and AF Susceptibility via Inhibition of Bax‐Mediated Mitochondrial Apoptosis

Haoyu Gong, Lingyan Jin, Yudi Zhang, Lulu Gong et autres

Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, has been shown in our prior work to be mitigated by swim exercise. While accumulating evidence links elevated circulating branched-chain amino acids (BCAA) to cardiovascular disease, their specific involvement in AF pathogenesis and …

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Value of the combination of intraepithelial tumor-infiltrating lymphocyte density and the heterogeneity of density as a prognostic marker in stage III colorectal cancers.

Hye‐Yeong Jin, Lingyan Jin, Seung Yeon Yoo, Nam-Yun Cho et autres

mutation. The combination of both intraepithelial TIL density and density heterogeneity was significantly associated with the prognosis of patients: low TIL density/high TIL heterogeneity showed hazard ratios of 3.284 (1.639-6.578) and 4.176 (1.713-10.178) in the discovery and validation cohorts, respectively. Our findings …

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Aberrant Cytoplasmic p53 Expression and Its Correlation with TP53 Mutation Status and Functional Implications in Stage II and III Colorectal Cancer

Meejeong Kim, Lingyan Jin, Hye‐Yeong Jin, Nam-Yun Cho et autres

INTRODUCTION: TP53 mutation is frequently observed in colorectal cancer (CRC) and is often linked to associated with immunohistochemical p53 expression patterns. Recent studies have identified cytoplasmic p53 expression in CRC, but its correlation with TP53 mutation domains and functional properties remains unclear. …

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The oncogenic role of hypomethylated ZNF793 in gastric carcinoma: a focus on cell survival and stemness

Lingyan Jin, Hye‐Yeong Jin, Meihui Li, Young-Hoon Kim et autres

BACKGROUND: Although genome-wide promoter CpG island hypermethylation of Epstein-Barr virus-associated gastric carcinoma (EBV GC) is well known, ZNF793 is rarely methylated in EBV GC but is frequently methylated in other molecular subtypes of GC, including microsatellite instability-high GC. Based on the hypothesis …

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Kininogen enhances seizure susceptibility in mice possibly through bradykinin-induced modulation of calcium transients in glutamatergic and GABAergic neurons

Arijit Ghosh, Qian Wang, Yanling Gong, Srishti Jain et autres

Background Previously we showed that elevated cerebrospinal fluid (CSF) levels of kininogen during the acute phase of encephalitis are associated with symptomatic epilepsy. However, the functional role of kininogen in epileptogenesis remains unexplored. Objective This study investigated the brain expression of kininogen …

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Motor protein KIF5B inhibition as a novel strategy of controlled reperfusion against myocardial ischemia/reperfusion injury

Feng Gao, Yudi Zhang, Lingyan Jin, Haoyu Gong et autres

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Clinicopathological and molecular features of genome-stable colorectal cancers.

Lingyan Jin, Hye‐Yeong Jin, Young‐Hoon Kim, Nam-Yun Cho et autres

mutations.

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Succinate predisposes mice to atrial fibrillation by impairing mitochondrial function via SUCNR1/AMPK axis

Yudi Zhang, Haoyu Gong, Lingyan Jin, Peng Liu et autres

Atrial fibrillation (AF), a major public health concern, is associated with high rates of death and disability. Mitochondrial dysfunction has emerged as a key contributor to the pathophysiology of AF. Succinate, an essential Krebs cycle metabolite, is often elevated in the circulation …

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Long-term glucosamine supplementation aggravates atrial fibrillation susceptibility by impairing AMPK signaling

Xinghua Qin, Haoyu Gong, Lingyan Jin, Yixin Wang et autres

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Succinate Predisposes Mice to Atrial Fibrillation by Impairing Mitochondrial Function Via Sucnr1/Ampk Axis

Yudi Zhang, Haoyu Gong, Lingyan Jin, Peng Liu et autres

cn, us (code pays fourni par la source)