Exploring the potential causal association between oral microbiota and heart failure using Mendelian randomization in an East Asian population
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Le résumé fourni par la source
Growing evidence suggests that the gut microbiota is closely associated with the risk of developing heart failure (HF). However, the potential impact of oral microbiota on HF has received far less attention. Using instrumental variable from the latest genome-wide association study data in East Asian populations, we evaluated the genetic predisposition to HF associated with 455 salivary microbiota and 540 tongue microbiota. The HF dataset was derived from Biobank Japan, including 9413 HF cases and 203,040 controls. The inverse-variance weighted method was used to assess potential causal associations between oral microbiota and HF. Robustness of the results was confirmed through MR-Egger regression intercept test and MR-PRESSO global test. Inverse-variance weighted analysis identified 33 tongue microbiota, including Veillonella atypica 1903 (odds ratio [OR] = 0.84, 95% confidence interval [CI]: 0.74-0.97, P = .013), and 28 salivary microbiota, including Centipeda massiliensis 3300 (OR = 0.79, 95% CI: 0.67-0.94, P = .007), that may be negatively associated with HF. Conversely, 25 tongue microbiota, such as Streptococcus pneumoniae 1744 (OR = 1.50, 95% CI: 1.16-1.94, P = .001), and 30 salivary microbiota, including Fusobacterium massiliense 586 (OR = 1.50, 95% CI: 1.31-1.63, P = .017), showed a potential positive association with HF. Sensitivity analyses confirmed the stability of these results. This study has preliminarily identified multiple oral microbiota that may have a causal association with the risk of developing HF, providing a more reliable theoretical basis for exploring the microbiota-related mechanisms underlying HF.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Exploring the potential causal association between oral microbiota and heart failure using Mendelian randomization in an East Asian population
- Date Crossref
- 10/10/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Westlake University Affiliated Hangzhou First People's Hospital pays non établi dans la noticeÉtablissement de santé
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Xuzhou Medical College pays non établi dans la noticeUniversité ou école supérieure
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Jinan Central Hospital pays non établi dans la noticeÉtablissement de santé
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Shandong First Medical University Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
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Jiande First People’s Hospital Department of Cardiology pays non établi dans la noticeÉtablissement de santé
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The Affiliated Hospital of Xuzhou Medical University Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
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104:41(e44711) pays non établi dans la noticeInstitution
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Man Y. Exploring the potential causal association between oral microbiota and heart failure using Mendelian randomization in an East Asian population. Medicine 2025 Wang L pays non établi dans la noticeOrganisation à but non lucratif
Affiliated Hangzhou First People's Hospital — Westlake University, Xuzhou Medical College et Jinan Central Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.