Ke Li

TRIM2 Facilitates Macrophage Mediated Anti-tumour Immunity in Renal Cell Carcinoma through Enhancing SIRPA Ubiquitination and Degradation

Tingting Zhang, Shuhua He, Chenxi Zhao, Feng Wang et autres

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Non-epithelial Circulating Tumor Cells Enhance Disease Progression in High-risk Prostate Cancer through EMT and COL1A1 Expression

Yiyuan Li, Ruji Wu, Hua Wang, Meinong Zhong et autres

Introduction: Circulating tumor cells (CTCs) are important prognostic indicators for malignancies.However, a reliable positive/negative cutoff value of non-epithelial (NE + : hybrid and mesenchymal) CTCs phenotype in prostate cancer (PCa) patients has not been established.Here, we aimed to determine the cutoff value …

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Novel Dual-Functional Half-Curcumin Analogues as a Fluorescent and PET Probe for β-Amyloid Imaging in the Alzheimer’s Disease APP/PS1 Model

Haijun Yang, Ke Li, Tingfang Wang, Yi Zou et autres

Noninvasive imaging of β-amyloid in vivo is pivotal for the early diagnosis of Alzheimer’s disease (AD). While single imaging methods have been extensively studied for detecting Aβ over the past decade, dual-modal probes have received scant attention. In this study, we synthesized …

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An In‐Situ‐Tag‐Generation Proximity Labeling Technology for Recording Cellular Interactions

Yunyan Yao, Ru Jia, Chuanming Liu, Haiqi Wang et autres

Obtaining information about cellular interactions is fundamental to the elucidation of physiological and pathological processes. Proximity labeling technologies have been widely used to report cellular interactions in situ; however, the reliance on addition of tag molecules typically restricts their application to regions …

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Nanoparticle Polymeric Micellar Paclitaxel Versus Paclitaxel for Patients with Advanced Gastric Cancer

Feiyu Wang, Xiangming Huang, Jie Cao, Ke Li et autres

Abstract Background Nanoparticle polymeric micellar paclitaxel (NPMP) is a novel Cremophor EL (CrEL)-free nanoparticle micellar formulation of paclitaxel. This study evaluated the efficacy and toxicity of NPMP in the treatment of patients with advanced gastric cancer (AGC). Methods Patients with histologically confirmed …

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A prognostic model of idiopathic pulmonary fibrosis constructed based on macrophage and mitochondria-related genes

Yu Bao, Shiyuan Yang, Hailan Zhao, Yezhen Wang et autres

BACKGROUND: Studies have shown that mitochondrial function and macrophages may play a role in the development of idiopathic pulmonary fibrosis (IPF). However, the understanding of the interactions and specific mechanisms between mitochondrial function and macrophages in pulmonary fibrosis is still very limited. …

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A prognostic model of idiopathic pulmonary fibrosis was constructed based on macrophage-related genes and mitochondria-related genes

Yu Bao, Shiyuan Yang, Hailan Zhao, Xue Li Zhu et autres

Abstract Background Studies have shown that mitochondrial function and macrophages may play a role in the development of idiopathic pulmonary fibrosis (IPF). However, the mechanism of macrophages and mitochondria in IPF is not fully understood. Methods To construct a prognostic model for …

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Astaxanthin ameliorates oxidative stress in lens epithelial cells by regulating GPX4 and ferroptosis

Deqian Kong, Yue Liu, Li Li, Huajun Wang et autres

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Correlation Study Between Core Stability and Landing Kinetics of Freestyle Skiing Aerials Elite Athletes

Ming Wei, Yongzhao Fan, Haiying Ren, Ke Li et autres

Abstract Core stability can improve athletic performance and reduce the risk of injury, and is one of the most important elements of athletic training. However, the effect of core stability on the Landing kinetics is still unclear. Therefore, the analysis and discussion …

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Confirmation Key Genes Associated with TNM Staging Classified as T3 and T4 in Lung Squamous Cell Carcinoma with Bioinformatics Analysis

Qian Li, Hao Liu, Ke Li, Hui Wang et autres

Abstract Background: Lung cancer is a high occurrence rate and mortality rate cancer. Non-small cell lung cancer (NSCLC) is confirmed in 80–85% of lung cancer cases. Lung squamous cell carcinoma (LUSC) is frequently diagnosed at the advanced stage with poor prognoses. The …

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A novel lipid metabolism gene signature for clear cell renal cell carcinoma using integrated bioinformatics analysis

Ke Li, Yan Zhu, Jiawei Cheng, Anlei Li et autres

Background: Clear cell renal cell carcinoma (ccRCC), which is the most prevalent type of renal cell carcinoma, has a high mortality rate. Lipid metabolism reprogramming is a hallmark of ccRCC progression, but its specific mechanism remains unclear. Here, the relationship between dysregulated …

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Evaluation of NOTCH family genes’ expression and prognostic value in prostate cancer

Yunhao Qing, Yu Wang, Cheng Hu, Huimin Zhang et autres

Background: Abnormal regulation of the NOTCH signaling pathway in prostate cancer (PCa) can promote tumorigenesis, progression, and T cell exhaustion.However, there has not been a comprehensive analysis of NOTCH family genes (NOTCHs) as potential therapeutic targets and prognostic biomarkers for PCa patients.Methods: …

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