Qian Li

Associations of Green Space and Air Pollution Mixture with Heterogeneous Biological Aging Patterns

Guoqiang Ma, Jing Xu, Yishu Li, Yuefei Wu et autres

Abstract Evidence on associations between green space, air pollution mixture, and heterogeneous biological aging patterns remains limited. We investigated the opposing effects of green space and air pollution mixture on biological aging patterns using an accelerated longitudinal design based on repeated-measures data …

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Macrophage USP7 aggravates acute myocardial infarction by inhibiting STING degradation through the ESCRT pathway

Wenqian Qi, Ruiqing Ren, Liwen Yu, Lei Cao et autres

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SLC25A39 potentiates the RXFP1/cAMP/PKA/CREB axis to drive metabolic reprogramming and tumor progression in ovarian cancer

Tian Tian, Jiming Bai, Qian Li, Qing Li et autres

The mitochondrial transporter SLC25A39 mediates GSH transport from the cytosol to mitochondria and is essential for maintaining mitochondrial oxidative homeostasis and function. However, its exact molecular mechanism in ovarian cancer has not yet been elucidated. In the present work, protein and mRNA …

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Experimental investigation and network pharmacology-based analysis of the anticancer mechanisms of Fei Jin Sheng formula

Zhen Yan, Qian Li, Jian-Xiang Chen, Ying-Gen Sheng et autres

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Magnetic resonance-guided laser interstitial thermal therapy for mesial temporal lobe epilepsy (MINE): a single-centre, prospective, randomised, open-label, blinded-endpoint controlled trial protocol in China

Jiajie Mo, Du Cai, Quan Zhou, Sihan Dong et autres

INTRODUCTION: Drug-resistant mesial temporal lobe epilepsy (mTLE) is a common and disabling focal epilepsy syndrome for which surgery offers the best chance of seizure freedom. Traditional open surgery (eg, anterior temporal lobectomy or selective amygdalohippocampectomy) is effective but may be associated with …

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Abstract Thu103: Non-Fibrillar Collagen Type VIII Modulates Endothelial Cytoskeleton and Activation

Qian Li, Yi Qing, Catherine Wang, Lifang Ye et autres

Introduction: Collagen type VIII alpha 1 is enriched in atherosclerotic lesions and vascular remodeling, but its contribution to endothelial mechanics and signaling is not well defined. Hypothesis: We tested the hypothesis that collagen type VIII alpha 1 (COL8A1) regulates endothelial cytoskeletal organization, …

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Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion

Zhou Sha, Kun Yu Yang, Shoupeng Fu, Xiaoyong Tong et autres

Acute central nervous system infection is highly lethal, yet the mechanisms by which intracellular bacteria infiltrate the brain remain unclear. Phagocytes are central to host defense, but how infected cells facilitate bacterial access to the brain is poorly defined. In this study, …

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Intercellular mitochondrial transfer rewires redox signaling and metabolic plasticity: mechanisms, disease relevance and therapeutic frontiers

Jiahui Wang, Rongqing Li, Qian Li

Intercellular mitochondrial transfer is recognized as a central mechanism that shapes redox homeostasis, metabolic plasticity, and cellular resilience across multiple tissues. Through tunneling nanotubes (TNTs), extracellular vesicles (EVs), gap junction channels (GJCs), and cell fusion, mitochondria move between donor and recipient cells …

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Electrochemical Synthesis of Pyrrolo[1,2-a]quinoxalines by Cyclization of 2-(1H-pyrrol-1-yl)anilines and Alcohols

Ying-Xue Ji, Wenxue Li, Ye Zhang, Zhen Zheng et autres

Abstract The electrochemical synthesis of pyrrolo[1,2-a]quinoxalines features the use of ethanol as both the reactant and solvent and a broad substrate scope, thus affording a wide range of 4methylpyrrolo[1,2-a]quinoxalines in moderate to good yields. Notably, for this efficient electrochemical synthesis protocol, neither …

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Development of a Stereolithography 3D Printing-Based Micropatterning Method to Study Endothelial-to-Mesenchymal Transition Mechanobiology

Sarah Chesley, Megan Ho, Emily Lin, Kathryn Saxton et autres

Endothelial-to-mesenchymal transition (EndMT) is the process of endothelial cells undergoing molecular changes that shift their phenotype from that of endothelial cells to that of mesenchymal-like cells. It is a crucial developmental process that has been implicated in various physiological and pathological conditions. …

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FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice

Jie Zhou, Shuxin Wang, Jiaxin Lou, Beibin Pan et autres

Podocyte injury is central to diabetic kidney disease (DKD) pathogenesis, however, the mechanisms underlying podocyte loss remain unclear. Emerging evidence underscores the involvement of fibroblast growth factors (FGFs) in renal pathophysiology. Here we reveal a previously unappreciated role of podocyte-secreted FGF4 in …

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Gravity gliding controls gold mineralization at the Shiqiaopu deposit, Xuefengshan Orogen, South China: Insights from structural analysis

Hao Zeng, Han Zheng, Yu Zhang, Shibo Han et autres

• Gravity gliding drives orogenic gold at Shiqiaopu deposit. • Paleostress inversions prove gravity-induced stress overprint. • Ductile-brittle shear zones host auriferous pyrite via fault-valve cycling. • Metamorphic fluids dominate mineralization in décollement shear zones. Gravity gliding, a fundamental process in intracontinental …

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