Chi Wang

Benchmarking progression-free survival ratio as primary endpoint in precision oncology clinical trials

Federico Nichetti, Jennifer Hüllein, Pauline du Rusquec, Erin Pleasance et autres

Abstract Progression Free Survival Ratio (PFSratio), as defined as the ratio between PFS on investigational treatment (PFS2) and PFS on the last prior therapy (PFS1), is a popular endpoint in precision oncology (PO) studies. In this work, five methodologies for PFSratio-based trial …

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The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1

Fengyi Mao, Sai Wu, Derek B. Allison, Daheng He et autres

Polo-like kinase 1 (PLK1), a critical cell cycle regulator, is associated with cancer progression and negatively correlates with patient survival in cutaneous melanoma based on clinical database analysis. In a melanoma mouse model induced by BRafCA mutation and Pten-deficiency, we observed that …

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Lunar Orbital VLBI Experiment: Motivation, scientific purposes and status

Xiaoyu Hong, Weiren Wu, Qinghui Liu, Deng-Yun Yu et autres

Abstract The Lunar Orbital VLBI Experiment (LOVEX) is a scientific component of the Chinese Lunar Exploration Project (CLEP) Chang’E-7. The spaceborne component of LOVEX is implemented onboard the relay satellite QueQiao-2, which was launched on 20 March 2024, and later placed into …

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Glioblastoma-derived Extracellular Vesicles as modulators of Neuroinflammatory Responses and Tumor Aggressiveness

Sarah Brandão Palácio, Nicole Rummel, James N. Campbell, Allan Butterfield et autres

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Colon cancer in Appalachian Kentucky: Unique genetic, microbiome and obesity findings in a cohort comparison

Zeta Chow, Jinpeng Liu, Daheng He, Chi Wang et autres

We investigated colon cancer genomics and microenvironmental features in the Appalachian Kentucky population, a group with the highest incidence of colon cancer in the United States. We assessed two inter-related risk factors for colon cancer (obesity and abnormal gut bacterial microbiome) and …

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EP.13.29 Safety and Efficacy of DLL3 CAR-T Cells Armored With dnTGFBR2 in a Patient With Recurrent Small-Cell Lung Cancer

Zhonglin Hao, Ayman Qasrawi, H. Heath, S. Arnold et autres

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Cancer-associated fibroblast secreted DKK1 promotes the immunosuppressive tumor microenvironment and colorectal cancer resistance to chemotherapy

Zhijie Yin, Yuning Zhou, Xudong Zhu, Ryan Goettl et autres

Chemotherapy is the cornerstone of treatment for colorectal cancer (CRC). However, acquired resistance can lead to a decrease in the efficiency of chemotherapy. Here, we show that cancer-associated fibroblasts (CAFs) play a critical role in acquired resistance to chemotherapy. Treatment with 5-fluorouracil …

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A Bayesian Informative Shrinkage Approach for Large-scale Multiple Hypothesis Testing (BISHOT): with Applications in Differential Analysis of Omics Data

Ya Su, Chi Wang

A major goal of many omics studies is to identify differential features, e.g. differentially expressed genes, between experimental groups. When performing differential analysis for a given dataset, relevant information from another platform or species is often available. Incorporating such prior information can …

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495P Safety and efficacy of nab-sirolimus (HB1901) + endocrine therapy in HR+/HER2- advanced breast cancer after standard therapy failure: A multicenter, open-label, phase 2 study

Fei Ma, Hongnan Mo, Jie Cui, Bing Zhao et autres

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Lunar Orbital VLBI Experiment: motivation, scientific purposes and status

Xiaoyu Hong, Weiren Wu, Qinghui Liu, Deng-Yun Yu et autres

The Lunar Orbital VLBI Experiment (LOVEX) is a scientific component of the Chinese Lunar Exploration Project (CLEP) Chang'E-7. The spaceborne component of LOVEX is implemented onboard the relay satellite QueQiao-2, which was launched on 2024 March 20, and later placed into an …

Research progress of aqueous binders for sulfur cathode in lithium-sulfur battery

Chi Wang, Yifan Feng, Shaozhong Zeng

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Hsp47 drives obesity-associated breast cancer progression by enhancing asporin deposition in adipose tissue

Gaofeng Xiong, Daheng He, Dana Napier, Jing Chen et autres

Fibrosis is an important feature of adipose tissue in obese individuals; nevertheless, roles of obesity-associated extracellular matrix (ECM) deposition in breast cancer progression largely remain elusive. Here, we show that expression of Hsp47, a chaperone protein involving collagen secretion, is induced in …

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