Kan Li

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang et autres

ABSTRACT Despite architectural advances, current nerve guidance conduits inadequately replicate the mechanoactive microenvironment required for functional neural regeneration. While membrane tension is increasingly recognized as an important biomechanical regulator of axonal extension and glial behavior, its therapeutic exploitation in peripheral nerve repair …

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Development of Covalent Inhibitors of Chikungunya Virus nsP2 Cysteine Protease Enabled by Direct-to-Biology Synthesis and Screening

Zhengjun Cai, Kan Li, Sainetra Sridhar, Haozhou Tan et autres

Chikungunya virus (CHIKV), an arthropod-borne alphavirus, has emerged as a global health threat due to its rapid transmission and the lack of effective antiviral therapies. The cysteine protease activity of the virus-encoded nonstructural protein 2 (nsP2) is critical for CHIKV replication, as …

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PF4 drives mechanical overload-induced temporomandibular joint osteoarthritis through TLR2-dependent activation of NF-κB

Wei Sun, Jiashun Wu, Yu Liu, X G Li et autres

IGF2BP3 promotes gastric cancer progression by inhibiting ferroptosis through ETV4-mediated regulation of GCH1

Kan Li, Hui Wei, Fang Li, Y A Zheng et autres

Background Ferroptosis can be inhibited by insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) in cancers. ETS variant transcription factor 4 (ETV4) is aberrantly expressed in various cancers. Elevated transcription of guanosine triphosphate cyclohydrolase 1 (GCH1) contributes to tumor malignancy. This study …

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The Competitive Mechanism Of Ezh1 And Ezh2 In Promoting Oscc

Kan Li, Shanshan Tang, Hong Jiang, Guiqing Liao et autres

To elucidate the roles and competitive interplay of Enhancer of Zeste Homolog 1 (EZH1) and Enhancer of Zeste Homolog 2 (EZH2) in promoting oral squamous cell carcinoma (OSCC) progression. Bioinformatics analysis was performed using data from the Cancer Somatic Mutation Database (COSMIC) …

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Serial viral passage and reverse genetics protocol for identifying the antiviral drug targets of EV-D68 antivirals

Haozhou Tan, Kan Li, Jun Wang

Identifying antiviral targets and mechanisms is crucial for drug discovery. Here, we present a protocol to select EV-D68 variants resistant to Jun6504 by combining serial passage and reverse genetics. We describe steps for viral serial passage, sequencing, and viral genome mutagenesis. We …

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A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis

Kan Li, Michael J. Rudy, Yanmei Hu, Haozhou Tan et autres

Enterovirus D68 (EV-D68) is a respiratory virus that often causes mild to moderate respiratory illnesses and, in severe cases, can lead to paralysis and rarely death, mainly in children. There is currently no vaccine or antiviral for EV-D68. Here, we report the …

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Structural Analysis of the AlkB Family in Poultry

Yiding Niu, Kan Li, Xu You, Yutao Wu et autres

The objective of this study was to identify the AlkB family genes in poultry using bioinformatics, and to explore their molecular characteristics, evolutionary relationships, and expression patterns to clarify their potential functions in poultry. (1) Methods: The study utilized the NCBI database …

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Design of a Fluorescence Polarization Probe for Enterovirus 2C Proteins

Kan Li, Jun Wang

Enteroviruses (EVs), such as EV-D68, EV-A71, and CVB3, cause significant human disease; yet, no antivirals are currently approved. The highly conserved 2C protein, an essential AAA+ ATPase and helicase, is a prime antiviral target; however, it lacks suitable assays for inhibitor screening. …

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Identification of naturally occurring drug-resistant mutations of SARS-CoV-2 papain-like protease

Haozhou Tan, Qianru Zhang, Kyriakos Georgiou, Siyu Zhang et autres

The SARS-CoV-2 papain-like protease (PLpro) is a cysteine protease that cleaves viral polyproteins and antagonizes the host immune response during viral replication. Jun12682 and PF-07957472 are the first-in-class PLpro inhibitors showing potent in vivo antiviral efficacy in mouse models. In this study, …

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Development of a Novel Dynamic Weighted Imputation Algorithm for Soft Sensing with Missing Data

Minghao Li, Dongzhe Yang, Kan Li, Kai Sun et autres

Accurate measurement of grinding particle size in copper ore processing is crucial for production quality and efficiency. Due to the limitations of hardware sensors and high measurement costs, soft sensors technologies are widely used for prediction. However, missing data in collected datasets …

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Reproducible extracellular matrices for tumor organoid culture: challenges and opportunities

Kan Li, Yibo He, Xuejun Jin, Ketao Jin et autres

Tumor organoid models have emerged as valuable 3D in vitro systems to study cancer behavior in a physiologically relevant environment. The composition and architecture of the extracellular matrix (ECM) play critical roles in tumor organoid culture by influencing the tumor microenvironment and …

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