Jing Li

Enhanced diagnostic accuracy of high‐grade cervical intraepithelial neoplasia in postmenopausal women through PAX1 / JAM3 methylation analysis

Jing Li, Qun Zhou, Hui Ren Zhou, Jiaqi Peng et autres

This study aimed to assess the diagnostic-support and triage value of PAX1/JAM3 methylation testing for identifying high-grade cervical lesions among postmenopausal women referred for colposcopy. A total of 216 women aged ≥50 years who underwent colposcopy due to positive high-risk human papillomavirus …

cn (code pays fourni par la source)

Efficacy of stereotactic body radiotherapy in hepatocellular carcinoma with adrenal metastases: a retrospective analysis

Xi Cheng, Jing Li, Yong Li, Fenghua Liu et autres

Background: Hepatocellular carcinoma (HCC) with adrenal metastasis is associated with poor prognosis and lacks standardized treatment strategies. Stereotactic body radiotherapy (SBRT) is a promising non-invasive option, yet its efficacy in this setting remains underexplored. This study aims to evaluate the efficacy and …

cn (code pays fourni par la source)

Machine learning-based prognostic model for bloodstream infections in hematological malignancies using Th1/Th2 cytokines

Qin Li, Nan Lin, Zuheng Wang, Yuexi Chen et autres

OBJECTIVE: Bloodstream infection (BSI) is a significant cause of mortality in patients with hematologic malignancies(HMs), particularly amid rising antibiotic resistance. This study aimed to analyze pathogen distribution, drug-resistance patterns and develop a novel predictive model for 30-day mortality in HM patients with …

cn (code pays fourni par la source)

Development and assessment of the health-related quality of life scale for children with hearing loss in China

Jie Liu, Yuxiao Wang, Jing Li, Daichao Wu et autres

BACKGROUND: Hearing loss significantly affects children's lives; however, the health-related quality of life (QoL) of children with this disability is not well measured. We sought to develop a reliable and valid measure of health-related QoL in children with hearing loss. METHODS: We …

cn (code pays fourni par la source)

Abstract CT292: Phase II study of pembrolizumab in combination with lenvatinib in patients with triple negative breast cancer (TNBC), non-small cell lung cancer (NSCLC), and other tumor types and brain metastases

Ecaterina E Ileana Dumbrava, Emma J. Montazari, Uyen M. Vu, Tiantian Cai et autres

Abstract Background: Many patients develop brain metastasis during the course of their disease and it represents the cause of death in more than half of them. The prognosis and survival of patients with brain metastases remains poor with limited palliative treatment options. …

us (code pays fourni par la source)

Serum vitamin C levels and their correlation with chronic kidney disease in adults: a nationwide study

Chunli Wang, Jili Zhao, Qiaoqiao Zhou, Jing Li

INTRODUCTION: Inflammation and oxidative stress play significant roles in the development of chronic kidney disease (CKD). Given the recognized antioxidant properties of vitamin C, our study aimed to explore the correlation between CKD and serum vitamin C levels. METHODS: Data were gathered …

cn (code pays fourni par la source)

Fluorescent in situ hybridization has limitations in screening NRG1 gene rearrangements

Xiaomei Zhang, Lin Li, Fuping Gao, Binbin Liu et autres

BACKGROUND: NRG1 fusion is a promising therapeutic target for various tumors but its prevalence is extremely low, and there are no standardized testing algorithms for genetic assessment. MOTHODS: In this study, we analyzed 3008 tumors using Fluorescence in situ hybridization (FISH) and …

cn (code pays fourni par la source)

Progress of non-small-cell lung cancer with ROS1 rearrangement

Xin Yang, Zhe Tang, Jing Li, Jizong Jiang et autres

ROS1 rearrangement is found in 0.9%–2.6% of people with non-small-cell lung cancers (NSCLCs). Tyrosine kinase inhibitors (TKIs) target ROS1 and can block tumor growth and provide clinical benefits to patients. This review summarizes the current knowledge on ROS1 rearrangements in NSCLCs, including …

cn (code pays fourni par la source)

Non-small cell lung cancer cells with uncommon EGFR exon 19delins variants respond poorly to third-generation EGFR inhibitors

Zhiqin Lu, Yali Yi, Linxiao Wang, Yuxi Luo et autres

BACKGROUND: This study compared the clinical efficacy of first-, second-, and third-generation tyrosine kinase inhibitors (TKIs) in previously untreated non-small cell lung cancer (NSCLC) patients harboring uncommon epidermal growth factor receptor (EGFR) exon 19delins variants. METHODS: We retrospectively analyzed the clinical outcomes …

cn (code pays fourni par la source)

A qualitative research exploring the experiences of patients receiving immune checkpoint inhibitors for advanced lung cancer

Yunxia Hou, Ying-ge Hou, Jing Li, Lijuan Yu et autres

cn (code pays fourni par la source)

Development and validation of a novel nomogram for postoperative overall survival of patients with primary gastric signet-ring cell carcinoma: a population study based on SEER database

Duorui Nie, Hao Zheng, Guilin An, Jing Li

cn (code pays fourni par la source)

Case Report: Response to crizotinib treatment in a patient with advanced non-small cell lung cancer with LDLR-ROS1 fusion

Yun Shu, Zhouyu Wang, Hongjuan Shang, Wei Le et autres

C-ros oncogene 1 (ROS1) fusion is a pathogenic driver gene in non-small cell lung cancer (NSCLC). Currently, clinical guidelines from the National Comprehensive Cancer Network (NCCN) have recommended molecular pathologic tests for patients with NSCLC, including the detection of the ROS1 gene. …

cn (code pays fourni par la source)