Machine learning-based prognostic model for bloodstream infections in hematological malignancies using Th1/Th2 cytokines
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: Bloodstream infection (BSI) is a significant cause of mortality in patients with hematologic malignancies(HMs), particularly amid rising antibiotic resistance. This study aimed to analyze pathogen distribution, drug-resistance patterns and develop a novel predictive model for 30-day mortality in HM patients with BSIs. METHODS: A retrospective analysis of 231 HM patients with positive blood cultures was conducted. Logistic regression identified risk factors for 30-day mortality. Th1/Th2 cytokines were collected at BSI onset, with LASSO regression and restricted cubic spline analysis used to refine predictors. Seven machine learning(ML) algorithm (XGBoost, Logistic Regression, LightGBM, RandomForest, AdaBoost, GBDT and GNB) were trained using 10-fold cross-validation and model performance was evaluated with the ROC, calibration plots, decision and learning curves and the Shapley Additive Explanations (SHAP) analysis. The predictive model was developed by integrating Th1/Th2 cytokines with clinical features, aiming to enhance the accuracy of 30-day mortality prediction. RESULTS: Among the cohort, acute myeloid leukemia (38%) was the most common HM, while gram negative bacteria (64%) were the predominant pathogens causing BSI. Age, polymicrobial BSI, IL-4, IL-6 and AST levels were significant predictors of 30-day mortality. The Logistic Regression model achieved AUCs of 0.802, 0.792, and 0.822 in training, validation, and test cohorts, respectively, with strong calibration and clinical benefit shown in decision curves. SHAP analysis highlighted IL-4 and IL-6 as key predictors. CONCLUSIONS: This study introduces a novel ML-based model integrating Th1/Th2 cytokines and clinical features to predict 30-day mortality in HM patients with BSIs, demonstrating strong performance and clinical applicability.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Machine learning-based prognostic model for bloodstream infections in hematological malignancies using Th1/Th2 cytokines
- Date Crossref
- 26/03/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Guangxi Medical University Department of Hematology pays non établi dans la noticeUniversité ou école supérieure
-
Affiliated Hospital of Southwest Medical University Department of Hematology pays non établi dans la noticeÉtablissement de santé
-
First Affiliated Hospital of GuangXi Medical University pays non établi dans la noticeÉtablissement de santé
-
Southwest Medical University pays non établi dans la noticeÉtablissement de santé
-
Longmatan District Hospital of Traditional Chinese Medicine Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
-
School of Basic Medical Sciences Department of lmmunology pays non établi dans la noticeUniversité ou école supérieure
Department of Hematology — Guangxi Medical University, Department of Hematology — Affiliated Hospital of Southwest Medical University et First Affiliated Hospital of GuangXi Medical University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.