Yun Shu

MedMeta: An AI-Enabled and Genomics-Based Database for Functional Profiling of Secondary Metabolites in Medicinal Species

Fanbo Meng, Guiyang Zhang, Wenke Xiao, Yufei Mao et autres

Medicinal resources contain a vast array of secondary metabolites that play critical roles in disease treatment, health maintenance, and drug discovery. Nevertheless, challenges such as biosynthetic complexity and species-specific variability have long hindered their systematic exploration. Recent advances in omics technologies and …

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PD-1/CTLA-4 antibody AK104 in advanced solid tumors after PD/PD-L1 treatment failure: A retrospective cohort study

Herbert Yu, Yun Shu, Yingen Deng

AK104 is a novel antibody targeting programmed cell death protein 1 (PD-1)/cytotoxic T-lymphocyte-associated protein 4. This study aimed to evaluate the safety, tolerability, and efficacy of AK104 in treating patients with advanced solid tumors who failed prior programmed cell death protein 1/programmed …

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Flavoenzyme‐inspired Reductive Dehalogenation of α‐Br and α‐Cl Carbonyl Compounds with Riboflavin Tetraacetate as Photocatalyst

Xuan Zhang, Jin Ge, Qin Zhang, Chao-Yue Sun et autres

Abstract Reductive dehalogenation represented a straightforward way to the breakage of carbon‐halogen bonds, exerting great significance in organic synthesis and potential in environmental decontamination. Riboflavin, a small molecular, photosensitive, and redox‐responsible coenzyme in both oxidases and reductase, has inspired various biological and …

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Non-small cell lung cancer cells with uncommon EGFR exon 19delins variants respond poorly to third-generation EGFR inhibitors

Zhiqin Lu, Yali Yi, Linxiao Wang, Yuxi Luo et autres

BACKGROUND: This study compared the clinical efficacy of first-, second-, and third-generation tyrosine kinase inhibitors (TKIs) in previously untreated non-small cell lung cancer (NSCLC) patients harboring uncommon epidermal growth factor receptor (EGFR) exon 19delins variants. METHODS: We retrospectively analyzed the clinical outcomes …

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Development and validation of a scoring system to predict esophagogastroduodenoscopy necessity

Jing Yang, Yan Jing, Cen Xi Xiong, Xiao Mei Zhang et autres

OBJECTIVE: This study aimed to develop and validate a scoring system for predicting the need for esophagogastroduodenoscopy (EGD) in clinical practice to enhance accuracy and reduce misapplications. METHODS: From February 2021 to April 2022, outpatients scheduled for EGD at the Department of …

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Long-term prednisone treatment causes fungal microbiota dysbiosis and alters the ecological interaction between gut mycobiome and bacteriome in rats

Wenyan Li, Yun Shu, Jing Zhang, Mengmeng Wu et autres

Glucocorticoids (GCs) are widely used in the treatment of immune-mediated diseases due to their anti-inflammatory and immunosuppressive effects. Prednisone is one of the most commonly used GCs. However, it is still unknown whether prednisone affects gut fungi in rats. Herein we investigated …

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Patients harboring uncommon EGFR exon 19delins variants of advanced non-small-cell lung cancer and response to osimertinib: A multi-center retrospective study.

Zhiqin Lu, Yali Yi, Yuxi Luo, Zhimin Zeng et autres

e21184 Background: This study aims to investigate the efficacy of different EGFR inhibitors therapy in patients with advanced non-small-cell lung cancer (NSCLC) harboring atypical EGFR exon 19delins variants. Methods: Targeted sequencing database of 1426 treatment-naive patients with advanced NSCLC were retrospectively screened …

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Case Report: Response to crizotinib treatment in a patient with advanced non-small cell lung cancer with LDLR-ROS1 fusion

Yun Shu, Zhouyu Wang, Hongjuan Shang, Wei Le et autres

C-ros oncogene 1 (ROS1) fusion is a pathogenic driver gene in non-small cell lung cancer (NSCLC). Currently, clinical guidelines from the National Comprehensive Cancer Network (NCCN) have recommended molecular pathologic tests for patients with NSCLC, including the detection of the ROS1 gene. …

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Impacts of Landscape Type, Viewing Distance, and Permeability on Anxiety, Depression, and Stress

Yun Shu, Chengzhao Wu, Yujia Zhai

Contact with nature is beneficial for mental health, including anxiety and stress. Exposure to virtual nature also has similar restorative traits with real nature. However, previous studies on the restorative environment mostly focus on ordinary people while caring less about patients with …

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Research on uniaxial compression strength and failure properties of stratified rock mass

Zhihong Wang, Meng Wang, Lei Zhou, Zheming Zhu et autres

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Three Novel Genetic Variants in the FAM110D, CACNA1A, and NLRP12 Genes Are Associated With Susceptibility to Hypertension Among Dai People

Lin Xu Bao-Wei Zhang, Yun Sun, Xiaochao Zhang, Xiyun Shan et autres

BACKGROUND: Although the genetic factors associated with hypertension remain unknown, genetic variations in genes related to ion channels, inflammation, and the cell cycle may affect susceptibility to hypertension. In the present study, the association between hypertension and 10 candidate single-nucleotide polymorphisms (SNPs) …

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Identification of a Novel MPRIP-ROS1 Fusion and Clinical Efficacy of Crizotinib in an Advanced Lung Adenocarcinoma Patient: A Case Report

Yun Shu, Hui Li, Hongjuan Shang, Jun Chen et autres

OBJECTIVE: ROS1 fusions have been identified in 1-2% of non-small-cell lung cancer (NSCLC) patients; they are validated as a driver of carcinogenesis and could be subjected to inhibition by crizotinib. However, previous studies suggested a variable progression-free survival (PFS) ranging from 9.1 …

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