Sang‐Hyun Kim

Cathepsin L deletion enhances sensitivity to anticancer drugs through Parkin-mediated ubiquitination of Bcl-xL and USP53-induced Survivin destabilization

Seung Un Seo, Seon Min Woo, Yongsoo Kwon, Shin Kim et autres

Cathepsin L (Cat L), a lysosomal endopeptidase, is overexpressed in human renal clear carcinoma (RCC); however, its impact on apoptosis remains unclear. Results revealed that inhibition (SID, a specific inhibitor), knockdown (siRNA), or knockout of Cat L sensitizes human carcinoma cells to …

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Topical Nanocarrier-Assisted Corticosteroid Delivery Combined with Phototherapy for Effective Atopic Dermatitis Treatment

Young‐Ae Choi, Jun Young Park, Jinjoo Kang, Na-Hee Jeong et autres

Topical corticosteroids are widely used to manage chronic inflammatory skin diseases, such as atopic dermatitis (AD). However, their limited skin penetration necessitates high doses and prolonged use, which increases the risk of local and systemic side effects. To address these limitations, we …

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Ultrasound-Guided Integrated Musculoskeletal and Vascular Landmark Approach for Access to the Facial Nerve Trunk

Yumi Seo, Yonghyun Yoon, King Hei Stanley Lam, Sang‐Hyun Kim et autres

Background: Ultrasound is increasingly used in plastic surgery for real-time guidance in minimally invasive procedures. However, standardized approaches for targeting the facial nerve (FN) trunk, particularly for motor nerve interventions, remain limited. This study aimed to evaluate the anatomical feasibility of an …

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Amygdalin alleviates atopic dermatitis-like skin inflammation via inhibition of Th2 immune responses

Na-Hee Jeong, Young‐Ae Choi, Meiling Jin, Hyo-Hyun Park et autres

OBJECTIVE: Atopic dermatitis (AD) is a chronic skin disease marked by immune dysregulation such as upregulated T helper (Th) 2 responses. While Th2-targeted therapies for AD are under development, their application is limited by side effects such as hypereosinophilia and arthritis. Amygdalin …

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Protectin D1, an omega-3–derived lipid mediator, resolves mast cell–driven allergic inflammation via FcεRⅠ signaling

Jieun Yoon, Na-Hee Jeong, Young‐Ae Choi, Taeg Kyu Kwon et autres

Protectin D1 (PD1) derived from docosahexaenoic acid (DHA) has shown promise in resolving inflammation. Mast cells are critical drivers of allergic inflammation, releasing inflammatory mediators such as histamine and pro-inflammatory cytokines. This study assesses the effectiveness of PD1 in counteracting mast cell-mediated …

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Protectin D1 from ω-3 Fatty Acids Suppresses Mast Cell-Mediated Allergic Responses via FcɛRI-Mediated Signaling (Abstract ID: 164257)

Jieun Yoon, Seungwon Jeong, Soyoung Lee, Sang‐Hyun Kim

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Esculetin Inhibits Mast Cell-Mediated Allergic Inflammation and Anaphylaxis by Suppressing the FcɛRI Signaling Pathway (Abstract ID: 162178)

Seungwon Jeong, Soyoung Lee, Sang‐Hyun Kim

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Aspalathin, a key flavonoid in rooibos, restores STAT6-mediated immune dysregulation in atopic dermatitis

In‐Young Yang, Na‐Hee Jeong, Young‐Ae Choi, Dong Kyu Choi et autres

Atopic dermatitis (AD), a chronic inflammatory skin disease whose incidence is increasing worldwide, requires the development of alternative treatments due to limited treatment options and concerns about side effects of therapeutic agents. Aspalathin (ASP) is the primary flavonoid found in rooibos, an …

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The inhibitory effects of Hispidulin on mast cell-mediated allergic airway inflammation

Soyoung Lee, Seungwon Jeong, Chul-Kyu Park, Sang‐Hyun Kim

Abstract Allergic asthma is a type 2 immune-response-mediated chronic respiratory disease. Recent studies have shown that mast cell activation influences the development and aggravation of allergic asthma. Therefore, the development of mast cell-targeting pharmacotherapy is important for regulating allergic airway inflammation. We …

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Hispidulin Alleviates Mast Cell-Mediated Allergic Airway Inflammation through FcεR1 and Nrf2/HO-1 Signaling Pathway

Seungwon Jeong, Yeon‐Yong Kim, Dongwon Lee, Sang‐Hyun Kim et autres

Allergic asthma is a type 2 immune-response-mediated chronic respiratory disease. Mast cell activation influences the pathogenesis and exacerbation of allergic asthma. Therefore, the development of mast cell-targeting pharmacotherapy is important for managing allergic airway inflammation. We investigated the efficacy of hispidulin (HPD), …

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Ethanol Extract of Ampelopsis brevipedunculata Rhizomes Suppresses IgE-Mediated Mast Cell Activation and Anaphylaxis

Jiyeong Park, Min-Jong Kim, Young‐Ae Choi, Seung Woong Lee et autres

More than 20% of the world’s population suffers from allergic diseases, including allergic asthma, rhinitis, and atopic dermatitis that severely reduce the patient’s quality of life. The treatment of allergy has been developed, but there are still unmet needs. Ampelopsis brevipedunculata (Maxim.) …

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Ameliorated Skin Inflammation through the Synergistic Effect of Gold Nanorod–Dexamethasone and Photothermal Therapy

Nam-Kyung Kim, Yong‐Gyu Jeong, Soyoung Lee, Jinjoo Kang et autres

Psoriasis, a prevalent chronic inflammatory skin ailment affecting approximately 2-3% of the global population, is characterized by persistent symptoms. Dexamethasone, a primary corticosteroid for treating psoriasis, demonstrates notable efficacy; however, its limited skin permeation results in documented adverse effects. To address this, …

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