Jia He

Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

Yaying Zhu, Chengxiang Deng, Bo Chen, Jia He et autres

Hepatocytes undergo extensive proliferation to facilitate liver repair after injury, yet early adaptive changes prior to proliferation remain unclear. Here, we report that during early acetaminophen (APAP)-induced liver injury, hepatocytes exhibit transient proliferation suppression that is most pronounced in mid-zone hepatocytes, consistent …

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Differential regulation of hepatic macrophage fate by Chi3l1 in metabolic dysfunction-associated steatotic liver disease

Jia He, Bo Chen, Weiju Lu, Xiong Wang et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) progression involves the replacement of protective embryo-derived Kupffer cells (KCs) by inflammatory monocyte-derived macrophages (MoMFs), yet the regulatory mechanisms remain unclear. Here, we identify chitinase 3-like 1 (Chi3l1/YKL-40) as a critical metabolic regulator of hepatic macrophage …

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Evolution of flatband localization in disordered Moiré Lieb superlattice

Jia He, Haoming Chen, Qian Liu, Xiaoshuang Xia et autres

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Hyperactivated glycolysis drives spatially patterned Kupffer cell depletion in MASLD

Jia He, Ran Li, Cheng Xie, Zhao Shan

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) progression is characterized by hepatic inflammation and cell death, yet the mechanisms underlying Kupffer cells (KCs) loss remain poorly understood. Here, we sought to elucidate the metabolic basis of KCs death during MASLD. Using metabolomics, …

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Impact of allogeneic dental pulp stem cell injection on tissue regeneration in periodontitis: a multicenter randomized clinical trial

Yi Fan Liu, Yitong Liu, Jianhui Han, Lin Ye Song et autres

Abstract Periodontitis causes the destruction of tooth-supporting tissues, and current therapies for periodontal regeneration are invasive. In this study, a human dental pulp stem cell (DPSC; hDP-MSC) injection was developed to promote periodontal regeneration through a non-invasive procedure. A total of 132 …

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Phase and defect engineering of 1T/2H MoS2-x nanosheets for enhanced piezocatalytic inactivation of antibiotic-resistant bacteria

Huinan Zhao, Zhangnan Yao, Tao Li, Yanhong Lu et autres

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Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry

Jia He, Haibo Yu, Kunling Song, Ailong Huang et autres

Chronic hepatitis B virus (HBV) is a global health problem closely associated with a spectrum of liver diseases. Current clinical treatment options for HBV infection are generally not curative, highlighting the need for the development of novel therapeutics. Sodium taurocholate cotransporting polypeptide …

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Study on the Transverse Properties of T800-Grade Unidirectional Carbon Fiber-Reinforced Polymers

Hao Wang, Xiangyu Zhong, Jia He, Lian-Wang Zhang et autres

This paper focuses on the transverse tensile and compressive mechanical properties of T800-grade unidirectional (UD) carbon fiber-reinforced polymers (CFRPs). Firstly, transverse tensile and compressive tests were conducted on UD composite laminates, yielding corresponding stress-strain curves. The results indicated that, for tension, the …

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Study on Fe3o4-Modified Hydroxyapatite Whisker Composite Fiber Membrane for Skull Base Repair

Tingting Yan, Bin Chen, Ting Xiao, Zhimin Yu et autres

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Phase and Defect Engineering of 1t/2h Mos2-X Nanosheets for Enhanced Piezocatalytic Inactivation of Antibiotic-Resistant Bacteria

Huinan Zhao, Zhangnan Yao, Tao Li, Yanhong Lu et autres

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Fast Orthogonal Matching Pursuit Through Successive Regression

H. W. Yu, Jia He, Maggie X. Cheng

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Localisation and decoding of acoustoelectric brain imaging based on anisotropic brain models

Xue Wang, Chen Zhang, Guowei Chen, Jia He et autres

Acoustoelectric imaging (AEI) combines electroencephalography (EEG) and transcranial focused ultrasound (tFUS) with the advantages of high temporal and spatial resolution, which is expected to provide safe, accurate and non-invasive neurofunctional imaging of the brain. Previous AEI studies were mainly based on isotropic …

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