Kunling Song

Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry

Jia He, Haibo Yu, Kunling Song, Ailong Huang et autres

Chronic hepatitis B virus (HBV) is a global health problem closely associated with a spectrum of liver diseases. Current clinical treatment options for HBV infection are generally not curative, highlighting the need for the development of novel therapeutics. Sodium taurocholate cotransporting polypeptide …

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Neuropilin-1 is a novel host factor modulating the entry of hepatitis B virus

Haibo Yu, Jihua Ren, Haijun Deng, Linfeng Li et autres

BACKGROUND & AIMS: Sodium taurocholate cotransporting polypeptide (NTCP) has been identified as the cellular receptor for HBV. However, hepatocytes expressing NTCP exhibit varying susceptibilities to HBV infection. This study aimed to investigate whether other host factors modulate the process of HBV infection. …

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A rapid and simple non-radioactive assay for measuring uptake by solute carrier transporters

Kunling Song, Longbin Zhang, Xi’an Fu, Linfeng Li et autres

Introduction: Solute carrier (SLC) transport proteins play a crucial role in maintaining cellular nutrient and metabolite homeostasis and are implicated in various human diseases, making them potential targets for therapeutic interventions. However, the study of SLCs has been limited due to the …

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Corrigendum: Prostaglandin reductase 1 as a potential therapeutic target for cancer therapy

Xing Wang, Guobing Yin, Wei Zhang, Kunling Song et autres

• please read through all the templates before choosing • pick the most relevant text template(s) from the following page and delete all others.• edit the text as necessary, ensuring that the original incorrect text is included for the record, please see …

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Prostaglandin Reductase 1 as a Potential Therapeutic Target for Cancer Therapy

Xing Wang, Guobing Yin, Wei Zhang, Kunling Song et autres

Altered tumor metabolism is a hallmark of cancer and targeting tumor metabolism has been considered as an attractive strategy for cancer therapy. Prostaglandin Reductase 1 (PTGR1) is a rate-limiting enzyme involved in the arachidonic acid metabolism pathway and mainly responsible for the …

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Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease

L. Chen, N. Lim, Xiaotang Yuan, I. Surakka et autres

Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of LDL-c, HDL-c and triglycerides.