Accès ouvert
2026
preprint
OpenAlex
Yaying Zhu, Chengxiang Deng, Bo Chen, Jia He et autres
Hepatocytes undergo extensive proliferation to facilitate liver repair after injury, yet early adaptive changes prior to proliferation remain unclear. Here, we report that during early acetaminophen (APAP)-induced liver injury, hepatocytes exhibit transient proliferation suppression that is most pronounced in mid-zone hepatocytes, consistent …
cn
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Herui Fu, Jia Tie, Yan Zhou, Xin Wang et autres
Summary Lysosomal dysfunction is a hallmark of aging, yet whether microbial components actively regulate this organelle to influence longevity remains unknown. Here, we identify bacterial peptidoglycan (PGN), a major cell wall component degraded by host lysozyme, as an evolutionarily conserved activator of …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Jia He, Bo Chen, Weiju Lu, Xiong Wang et autres
Metabolic dysfunction-associated steatotic liver disease (MASLD) progression involves the replacement of protective embryo-derived Kupffer cells (KCs) by inflammatory monocyte-derived macrophages (MoMFs), yet the regulatory mechanisms remain unclear. Here, we identify chitinase 3-like 1 (Chi3l1/YKL-40) as a critical metabolic regulator of hepatic macrophage …
cn
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Ruoxue Yang, Jinghua Liu, Kai Fu, Ting Wan et autres
Platelets have emerged as active regulators of acute liver injury (ALI), yet the molecular mechanisms underlying their pathogenic functions remain poorly defined. Here, we demonstrate that platelets exacerbate liver injury by metabolically reprogramming Kupffer cells (KCs). We show that platelets are actively …
cn
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Ruoxue Yang, Jinghua Liu, Kai Fu, Ting Wan et autres
Platelets have emerged as active regulators of acute liver injury (ALI), yet the molecular mechanisms underlying their pathogenic functions remain poorly defined. Here, we demonstrate that platelets exacerbate liver injury by metabolically reprogramming Kupffer cells (KCs). We show that platelets are actively …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Jia He, Ran Li, Cheng Xie, Zhao Shan
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) progression is characterized by hepatic inflammation and cell death, yet the mechanisms underlying Kupffer cells (KCs) loss remain poorly understood. Here, we sought to elucidate the metabolic basis of KCs death during MASLD. Using metabolomics, …
cn
(code pays fourni par la source)
Accès ouvert
2026
peer-review
OpenAlex
Jia He, Ran Li, Cheng Xie, Xiane Zhu et autres
Metabolic dysfunction-associated steatotic liver disease (MASLD) progression is characterized by hepatic inflammation and cell death, yet the mechanisms underlying Kupffer cells (KCs) loss remain poorly understood. Here, we sought to elucidate the metabolic basis of KCs death during MASLD. Using metabolomics, immunostaining, …
cn, sg
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Ruoxue Yang, Jinghua Liu, Kai Dao Fu, Ting Wan et autres
Abstract Platelets have emerged as active regulators of acute liver injury (ALI), yet the molecular mechanisms underlying their pathogenic functions remain poorly defined. Here, we demonstrate that platelets contribute to liver injury, in part, by metabolically reprogramming Kupffer cells (KCs). We show …
cn
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Jia He, Bo Chen, Weiju Lu, Xiong Wang et autres
Metabolic dysfunction-associated steatotic liver disease (MASLD) progression involves the replacement of protective embryo-derived Kupffer cells (KCs) by inflammatory monocyte-derived macrophages (MoMFs), yet the regulatory mechanisms remain unclear. Here, we identify chitinase 3-like 1 (Chi3l1/YKL-40) as a critical metabolic regulator of hepatic macrophage …
cn
(code pays fourni par la source)
Accès ouvert
2026
peer-review
OpenAlex
Zhao Shan
The liver is a complex organ responsible for multiple functions, including metabolism, energy storage, detoxification, bile secretion, and immune regulation. Its highly organized vascular system plays a crucial role in maintaining functional zonation and tissue homeostasis. Within the liver, the hepatic artery, …
cn
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Jia He, Ran Li, Cheng Xie, Zhao Shan
Metabolic dysfunction-associated steatotic liver disease (MASLD) progression is characterized by hepatic inflammation and cell death, yet the mechanisms underlying Kupffer cell (KCs) loss remain unclear. This study aims to elucidate metabolic changes behind KCs death. Using metabolomics, immunostaining, and flow cytometry, we …
cn
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Jia He, Ran Li, Cheng Xie, Zhao Shan
Metabolic dysfunction-associated steatotic liver disease (MASLD) progression is characterized by hepatic inflammation and cell death, yet the mechanisms underlying Kupffer cell (KC) loss remain poorly understood. Here, we sought to elucidate the metabolic basis of KC death during MASLD. Using metabolomics, immunostaining, …
cn
(code pays fourni par la source)