Korneliusz Golebski

A functional cell model using basophil activation test to study molecular mechanisms and biomarkers of response to omalizumab treatment in patients with asthma

Boris Gole, Larisa Goričan, Gregor Jezernik, M Gorenjak et autres

Introduction Patients with severe asthma may benefit from targeted biological therapies. However, personalized therapy in children and adolescents with asthma, based on individual susceptibility to molecular mechanisms addressed by different biologicals is underdeveloped. Here, we established a functional in vitro model, to …

si, se, de, nl (code pays fourni par la source)

Mast-cell derived nerve growth factor drives ILC2 pro-tumoral functions in bladder cancer

Maryline Falquet, Hajar El Ahanidi, Alejandra Gomez‐Cadena, Ziyang Su et autres

Abstract Innate lymphoid cells type 2 (ILC2s) are key regulators of tissue homeostasis and inflammation. In cancer, ILC2s can exhibit pro-tumoral functions by increasing the myeloid derived suppressor cells (MDSC)/T-cell ratio. Nevertheless, the upstream ILC2 triggers remain poorly defined. Here, we identify …

ch, gb, it, nl, Maroc, fr (code pays fourni par la source)

Barrier dysfunction in nasal epithelium contributes to persistent inflammation in long COVID

Nadia Baalbaki, Daniëlle van Egmond, Patricia Jaeger, Merel E. B. Cornelissen et autres

Airway epithelial barrier integrity: an emerging treatable trait in asthma management

Miloš Jeseňák, Anna Bobčáková, Korneliusz Golebski, Inge Kortekaas Krohn et autres

sk, nl, be, se (code pays fourni par la source)

Barrier dysfunction in nasal epithelium contributes to persistent inflammation in long COVID

Nadia Baalbaki, Daniëlle van Egmond, Patricia Jaeger, Merel E. B. Cornelissen et autres

BACKGROUND: Long COVID (LC) is characterized by persistent symptoms associated with chronic inflammation and immune dysregulation, but the local tissue mechanisms driving these processes remain poorly understood. OBJECTIVE: Given that the nasal epithelium is the primary entry and infection site for SARS-CoV-2, …

nl, ch (code pays fourni par la source)

Impact of air pollution on COVID-19 severity: a systematic review of underlying biological mechanisms

Laura Houweling, Iris Rots, Lizan D. Bloemsma, Robert van Vorstenbosch et autres

Background Our recent systematic review highlighted key associations between ambient air pollution (AAP) exposure and COVID-19 severity. This systematic review aims to summarise toxicological studies on the biological mechanisms underlying these associations. Methods On 17 July 2025, PubMed, Embase, Scopus and Web …

nl (code pays fourni par la source)

Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response

Korneliusz Golebski, Janice A. Layhadi, Ümit Murat Şahiner, Esther Helen Steveling et autres

Toward precision medicine: Inflammatory nasal epithelial transcriptomic profiles in long COVID

Nadia Baalbaki, Jelle M. Blankestijn, Samuel W. Kazer, Mahmoud I. Abdel‐Aziz et autres

Rationale and objectives Little is known about the role of the nasal epithelium in long COVID. This study aimed to assess nasal epithelial transcriptomes of long COVID(LC) patients to unravel pathophysiological mechanisms for disease management. Methods Medical data and transcriptomes were obtained …

nl, ca, us (code pays fourni par la source)

The Omics Landscape of Long COVID —A Comprehensive Systematic Review to Advance Biomarker, Target and Drug Discovery

Nadia Baalbaki, Elise M. A. Slob, Samuel W. Kazer, Mahmoud I. Abdel‐Aziz et autres

An estimated 10% of coronavirus disease (COVID-19) survivors suffer from persisting symptoms referred to as long COVID (LC), a condition for which approved treatment options are still lacking. This systematic review (PROSPERO: CRD42024499281) aimed to explore the pathophysiological mechanisms underlying LC and …

nl, us, Égypte (code pays fourni par la source)

Pharmacotherapy from Pre-COVID to Post-COVID: Longitudinal Trends and Predictive Indicators for Long COVID Symptoms

Nadia Baalbaki, Sien T. Verbeek, Harm Jan Bogaard, Jelle M. Blankestijn et autres

BACKGROUND/OBJECTIVES: A significant number of COVID-19 cases experience persistent symptoms after the acute infection phase, a condition known as long COVID or post-acute sequelae of COVID-19. Approved prevention and treatment options for long COVID are currently lacking. Given the heterogeneous nature of …

nl (code pays fourni par la source)

Fatigue in severe pediatric asthma patients: Results of the PANDA study

Yoni E. van Dijk, Valerie S. L. Keuker, Simone Hashimoto, Niels W. Rutjes et autres

Abstract Background Fatigue is a commonly reported clinical symptom, yet research on fatigue in children with severe asthma is missing. We aimed to explore the extent of fatigue in severe pediatric asthma and identify associated factors. Method This study was conducted within …

nl (code pays fourni par la source)

Author response for "Fatigue in severe pediatric asthma patients: Results of the PANDA study"

Yoni E. van Dijk, Valerie S. L. Keuker, Simone Hashimoto, Niels W. Rutjes et autres