Bumhee Yang

Impact of Hematologic Malignancies on the Risk of Incident Bronchiectasis: A Nationwide Cohort Study in Korea

Eunchae Kim, Jun Yeun Cho, Hyeonkyun Noh, Dong Eun Kye et autres

kr (code pays fourni par la source)

Exploring Immune Dysfunction in Bronchiectasis: A Focus on Natural Killer Cells using Single-Cell Transcriptomes

Bumhee Yang, D. S. Kim, Geonhui Min, Insook Jeon et autres

Alveolar epithelial depletion of βPAK-interacting exchange factor drives spontaneous pulmonary fibrosis by impairing stemness

Han-Byeol Kim, Woogil Song, Sun-Ok Kim, Jin-Hee Park et autres

Aberrant repair/regeneration of alveolar epithelial stem cells is a key driver of pulmonary fibrosis (PF). While βPAK-interacting exchange factor (βPIX) is connected to stem cell signaling, its role in pulmonary fibrosis (PF) remains unknown. Here, we generated conditional βPIX knockout mice to …

kr, us (code pays fourni par la source)

Changing Clinical Characteristics, Diagnostic Patterns, and Outcomes of Tuberculosis in South Korea: The Korean Tuberculosis Cohort, 2019-2024

Jee Youn Oh, Ganghee Chae, Hyung Woo Kim, Jinsoo Min et autres

BACKGROUND: Tuberculosis (TB) remains a public health concern in South Korea despite declining national notifications. We evaluated temporal changes in clinical characteristics, diagnostic patterns, and treatment outcomes in the Korean Tuberculosis Cohort (KTBC) from 2019 to 2024. METHODS: We retrospectively analyzed prospectively …

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Diagnosis-time Risk Stratification for Tuberculosis Mortality in a Nationwide Public-Private Mix Program

Yun‐Jeong Jeong, Hyung Woo Kim, Jinsoo Min, Jiwon Lyu et autres

OBJECTIVES: Mortality remains a major barrier to tuberculosis (TB) control, as many deaths occur shortly after diagnosis. We aimed to identify determinants of mortality and develop diagnosis-time risk-prediction models for patients with TB. METHODS: We conducted a nationwide population-based cohort study using …

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Race-neutral Global Lung Function Initiative 2022 equations alter COPD trial eligibility in a northeast Asian COPD cohort.

Joon Young Choi, Hyun Woo Lee, Min Kwang Byun, Jeong-Woong Park et autres

https://bit.ly/4cG1OZt.

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Pre-existing chronic kidney disease and mortality in younger patients with tuberculosis: a nationwide prospective cohort study

Jee Youn Oh, Ganghee Chae, Hyung Woo Kim, Jinsoo Min et autres

kr, Éthiopie, pr (code pays fourni par la source)

Inflammatory bowel disease and risk of non-tuberculous mycobacterial pulmonary disease: a nationwide retrospective cohort study in Korea

Dong Eun Kye, Geonhui Min, Eunchae Kim, Heajung Lee et autres

Background: Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder of the gastrointestinal tract, and patients with IBD are vulnerable to infections. Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is an infection of concern in immunocompromised individuals. However, data on the risk of NTM-PD …

kr (code pays fourni par la source)

Alternative to invasive bronchoscopy: validating tracheal aspirates for microbiome profiling in intensive care unit pneumonia patients

Parshatd Govindasamy, Jun Yeun Cho, Jiyoul Yang, Bumhee Yang et autres

Pneumonia causes significant mortality in intensive care unit (ICU) patients, yet traditional culture-based pathogen detection lacks sufficient sensitivity. While bronchoalveolar lavage fluid (BAL) provides optimal diagnostic yield, bronchoscopy is often contraindicated in critically ill patients. This study compares the respiratory microbiome profiles …

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Race-neutral Global Lung Function Initiative 2022 equations alter COPD trial eligibility in a northeast Asian COPD cohort

Joon Young Choi, Hyun Woo Lee, Min Kwang Byun, Jeong-Woong Park et autres

Extract Forced expiratory volume in 1 s (FEV1) percent-predicted is a common eligibility criterion for pharmaceutical randomized controlled trials (RCTs) in chronic obstructive pulmonary disease (COPD). [1, 2] The Global Lung Function Initiative (GLI) recently introduced the race-neutral 2022-GLI reference equation to …

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Blood Eosinophil Count, Disease Severity, and Exacerbation Risk in Korean Patients with Bronchiectasis: A Retrospective Cohort Study

Sun-Hyung Kim, Dong Eun Kye, Geun-Hyeong Kim, Jiyoul Yang et autres

BACKGROUND: Peripheral blood eosinophil count has been associated with bronchiectasis outcomes, but findings are inconsistent. Its role in acute exacerbations among Korean patients remain unclear. METHODS: This study retrospectively evaluated 492 patients with bronchiectasis at a tertiary hospital in Korea between 2014 …

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Risk of pulmonary aspergillosis in tuberculosis survivors: A nationwide population-based study

Sungmin Zo, Kyu Na Lee, Kyungdo Han, Bo‐Guen Kim et autres

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