Taylor Oniskey

Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets

Michael H. Guo, Prashanth Sama, Brenna A. LaBarre, Hrishikesh Lokhande et autres

Abstract Background Multiple sclerosis (MS) is an autoimmune condition of the central nervous system with a well-characterized genetic background. Prior analyses of MS genetics have identified broad enrichments across peripheral immune cells, yet the driver immune subsets are unclear. Results We utilize …

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Additional file 1 of Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets

Michael H. Guo, Prashanth Sama, Brenna A. LaBarre, Hrishikesh Lokhande et autres

Additional file 1: Supplementary Tables. Table S1. MS GWAS enrichment in 16 hematopoietic cell types. Table S2. MS GWAS enrichment of hematopoietic cell types in joint model. Table S3. MS GWAS pairwise enrichment in 16 hematopoietic cell types. Table S4. MS GWAS …

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Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets

Michael H. Guo, Prashanth Sama, Brenna A. LaBarre, Hrishikesh Lokhande et autres

Abstract Multiple sclerosis (MS) is an autoimmune condition of the central nervous system with a well-characterized genetic background. Prior analyses of MS genetics have identified broad enrichments across peripheral immune cells, yet the driver immune subsets are unclear. We utilized chromatin accessibility …

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TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths

Nicole Maloney Belle, Yingbiao Ji, Karl Herbine, Yun Wei et autres

Intestinal epithelial cells (IEC) have important functions in nutrient absorption, barrier integrity, regeneration, pathogen-sensing, and mucus secretion. Goblet cells are a specialized cell type of IEC that secrete Trefoil factor 3 (TFF3) to regulate mucus viscosity and wound healing, but whether TFF3-responsiveness …

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TFF3 is a ligand for LINGO2 that de-represses EGFR to control disease outcome during colitis and gastrointestinal nematode infection

Yingbiao Ji, Yun Wei, JoonHyung Park, Li‐Yin Hung et autres

Summary Intestinal epithelial cells (IEC) comprise diverse lineages that serve distinct roles necessary for regulation of nutrient absorption, regeneration, immunity, and homeostasis 1,2 . Goblet cells secrete Trefoil factor 3 (TFF3) to maintain mucus viscosity and drive mucosal healing by inhibiting cell …

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Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism

Li‐Yin Hung, Debasish Sen, Taylor Oniskey, Jeremey Katzen et autres

Coordinated efforts between macrophages and epithelia are considered essential for wound healing, but the macrophage-derived molecules responsible for repair are poorly defined. This work demonstrates that lung macrophages rely upon Trefoil factor 2 to promote epithelial proliferation following damage caused by sterile …

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Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells

Li‐Yin Hung, Taylor Oniskey, Debasish Sen, Matthew F. Krummel et autres

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Macrophage-Dependent Regeneration of Pulmonary Epithelia Requires Trefoil Factor 2 for Wnt Expression

Li‐Yin Hung, Debasish Sen, Taylor Oniskey, Wildaliz Nieves et autres

Abstract Coordination between epithelial and myeloid cell lineages may facilitate tissue repair, but mechanistic evidence is lacking. Independently of Type 2 cytokines (interleukin-4/13), and T, B or ILC populations, lung macrophages promoted epithelial proliferation following injury caused by Nippostrongylus brasiliensis or bleomycin …

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Myeloid-Restricted AMPKα1 Promotes Host Immunity and Protects against IL-12/23p40–Dependent Lung Injury during Hookworm Infection

Wildaliz Nieves, Li‐Yin Hung, Taylor Oniskey, Louis Boon et autres

How the metabolic demand of parasitism affects immune-mediated resistance is poorly understood. Immunity against parasitic helminths requires M2 cells and IL-13, secreted by CD4(+) Th2 and group 2 innate lymphoid cells (ILC2), but whether certain metabolic enzymes control disease outcome has not …

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Myeloid expression of the AP ‐1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections

Mary F. Fontana, Alyssa Baccarella, Danielle Kellar, Taylor Oniskey et autres

Activation of macrophages is a key step in the initiation of immune responses, but the transcriptional mechanisms governing macrophage activation during infection are not fully understood. It was recently shown that the AP-1 family transcription factor JUNB positively regulates macrophage activation in …

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Trefoil factor 2 maintains and restores pulmonary function via promoting epithelial repair and M2 activation (MUC5P.859)

De’Broski R. Herbert, Li‐Yin Hung, Debasish Sen, Taylor Oniskey et autres

Abstract Mechanisms responsible for pulmonary tissue homeostasis and regeneration are incompletely understood. This study investigated whether Trefoil factor family (TFF) proteins, regulators of gastrointestinal restitution, served any role in the pulmonary tract under steady state conditions or pathogen infection. At baseline, TFF2 …

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