Accès ouvert
2024
article
OpenAlex
Lucas Ethgen, Christopher F. Pastore, Cailu Lin, Danielle R. Reed et autres
Host defense at the mucosal interface requires collaborative interactions between diverse cell lineages. Epithelial cells damaged by microbial invaders release reparative proteins such as the Trefoil factor family (TFF) peptides that functionally restore barrier integrity. However, whether TFF peptides and their receptors …
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2021
conference-abstract
OpenAlex
Nicole Maloney Belle, Christopher F. Pastore, E Evonne Jean, De’Broski R. Herbert
Abstract T helper type 2 (TH2) cells are critical for clearance of parasitic helminth infections. Their coordinated efforts harness cellular and molecular pathways to expel worms, resolve intestinal inflammation and drive tissue repair. Yet the mechanisms that control TH2 cell activation, maintenance, …
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Accès ouvert
2019
article
OpenAlex
Nicole Maloney Belle, Yingbiao Ji, Karl Herbine, Yun Qi Wei et autres
Intestinal epithelial cells (IEC) have important functions in nutrient absorption, barrier integrity, regeneration, pathogen-sensing, and mucus secretion. Goblet cells are a specialized cell type of IEC that secrete Trefoil factor 3 (TFF3) to regulate mucus viscosity and wound healing, but whether TFF3-responsiveness …
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(code pays fourni par la source)