Brenna A. LaBarre

Nasal Foralumab for the Treatment of Progression Independent of Relapses in Patients With Nonactive Secondary Progressive Multiple Sclerosis

Tanuja Chitnis, Tarun Singhal, Jonathan Zurawski, Taylor J. Saraceno et autres

Progression independent of relapses (PIRA) is a major therapeutic challenge in multiple sclerosis (MS). Nasal anti-CD3 treats animal models of progressive MS by inducing regulatory T cells (Tregs) that suppress CNS inflammation and lessen clinical disease.

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Sex differences in progressive multiple sclerosis brain gene expression in oligodendrocytes and OPCs

Brenna A. LaBarre, D. A. King, Athanasios Ploumakis, Alfredo Pinzón et autres

Multiple sclerosis is a neurological autoimmune disease with sex-imbalanced incidence; in the USA, the disease is more likely to affect females at a ratio of 3:1. In addition, males are more likely to have a more severe disease course at time of …

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FABP7 is increased in progressive multiple sclerosis and induces a pro-inflammatory phenotype in monocytes through a glycolytic switch

Rohit Patel, D. A. King, Brenna A. LaBarre, Hrishikesh Lokhande et autres

Multiple sclerosis (MS) involves dysregulation of innate immune cells including monocytes, especially in progressive MS. Fatty acid binding proteins (FABP) are essential for fatty acid transport and metabolism in multiple cell types. FABP7, a brain-FABP, maintains metabolic function in astrocytes and neural …

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Nasal foralumab treatment of PIRA induces regulatory immunity, dampens microglial activation and stabilizes clinical progression in non-active secondary progressive MS

Tanuja Chitnis, Tarun Singhal, Jonathan Zurawski, Taylor J. Saraceno et autres

Background: Progression independent of relapses (PIRA) is a major therapeutic challenge in multiple sclerosis (MS). Nasal anti-CD3 treats animal models of progressive MS by inducing regulatory T cells (Tregs) that suppress central nervous system (CNS) inflammation and lessen clinical disease. Methods: Ten …

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Endocrine disrupting chemicals in early MS disease activity

Tzu-Ying Chuang, Brenna A. LaBarre, Osman Corbali, Brian C. Healy et autres

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Sex differences in progressive multiple sclerosis brain gene expression in oligodendrocytes and OPCs

Brenna A. LaBarre, D. A. King, Athanasios Ploumakis, Alfredo Pinzón et autres

Multiple sclerosis is a neurological autoimmune disease with sex-imbalanced incidence; in the USA, the disease is more likely to effect females at a ratio of 3:1. In addition, males are more likely to have a more severe disease course at time of …

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Endocrine Disrupting Chemicals in Early Ms Disease Activity

Tanuja Chitnis, Brenna A. LaBarre, Taylor J. Saraceno, Talia Feldman et autres

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Characterization of CD41+ cells in the lymph node

Li Dai, Mayuko Uehara, Xiaofei Li, Brenna A. LaBarre et autres

Lymph nodes (LNs) are the critical sites of immunity, and the stromal cells of LNs are crucial to their function. Our understanding of the stromal compartment of the LN has deepened recently with the characterization of nontraditional stromal cells. CD41 (integrin αIIb) …

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Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets

Michael H. Guo, Prashanth Sama, Brenna A. LaBarre, Hrishikesh Lokhande et autres

Abstract Background Multiple sclerosis (MS) is an autoimmune condition of the central nervous system with a well-characterized genetic background. Prior analyses of MS genetics have identified broad enrichments across peripheral immune cells, yet the driver immune subsets are unclear. Results We utilize …

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Additional file 1 of Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets

Michael H. Guo, Prashanth Sama, Brenna A. LaBarre, Hrishikesh Lokhande et autres

Additional file 1: Supplementary Tables. Table S1. MS GWAS enrichment in 16 hematopoietic cell types. Table S2. MS GWAS enrichment of hematopoietic cell types in joint model. Table S3. MS GWAS pairwise enrichment in 16 hematopoietic cell types. Table S4. MS GWAS …

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Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets

Michael H. Guo, Prashanth Sama, Brenna A. LaBarre, Hrishikesh Lokhande et autres

Abstract Multiple sclerosis (MS) is an autoimmune condition of the central nervous system with a well-characterized genetic background. Prior analyses of MS genetics have identified broad enrichments across peripheral immune cells, yet the driver immune subsets are unclear. We utilized chromatin accessibility …

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DNA methylation profiles unique to Kalahari KhoeSan individuals

Alexander Goncearenco, Brenna A. LaBarre, Hanna M. Petrykowska, Weerachai Jaratlerdsiri et autres

Genomes of KhoeSan individuals of the Kalahari Desert provide the greatest understanding of single nucleotide diversity in the human genome. Compared with individuals in industrialized environments, the KhoeSan have a unique foraging and hunting lifestyle. Given these dramatic environmental differences, and the …

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