Piotr Sosnowski

Methods used in the rehabilitation and treatment of scoliosis

Agnieszka Maria Kołodziejczyk, Mateusz Świątko, Piotr Sosnowski, Joanna Rybak et autres

The aim of this paper is to review and characterize the current rehabilitative and conservative methods used in the treatment of scoliosis.The importance of diagnosis is discussed and special attention is given to the effectiveness of modern physiotherapeutic methods, such as the …

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Pharmacometabolomics Detects Various Unreported Metoprolol Metabolites in Urine of (Potential) Living Kidney Donors and Kidney Transplant Recipients

Wietske A Heddema, Marieke A. J. Hof, Piotr Sosnowski, Stephan J. L. Bakker et autres

BACKGROUND AND OBJECTIVE: Metoprolol is primarily metabolized via the polymorphic cytochrome P450-2D6 (CYP2D6) enzyme, which underlies interindividual variation in conversion rates and may benefit from pharmacogenetics-driven therapy personalization. However, the field relies heavily on knowledge of a drug's metabolism, often originating from …

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The review of modern prospects for the pharmacological treatment of obesity and its complications – The role of GLP- 1, GLP1 / GIP, GLP1 / GIP / GCG receptor agonists

Michel Grzebyk, Anna Tokarska, Aleksandra Arnista, Mateusz Świątko et autres

Obesity has emerged as a global epidemic and a chronic neuroendocrine condition, significantly contributing to the prevalence of type 2 diabetes and other metabolic disorders.It is a key predictor of numerous health complications, including diabetic nephropathy, hepatic steatosis and fibrosis, obstructive sleep …

Perturbation-Modulated Native Mass Spectrometry Excludes a Nonspecific Drug Target Protein Binder Based on Conformation Stability Change

Xiaobo Tian, Patrick Mueller, Piotr Sosnowski, Fang Li et autres

Native electrospray ionization mass spectrometry (ESI-MS) is a standard technique for drug-protein screening but may be affected by nonspecific binding. To address this, a reference protein and ligand must be selected for each protein investigated. We report a versatile, informative, high-throughput screening …

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Machine learning-driven Raman spectroscopy: A novel approach to lipid profiling in diabetic kidney disease

Adrianna Kryska, Magdalena Sawic, Joanna Depciuch, Piotr Sosnowski et autres

band emerging as a potential spectroscopic marker for diabetic kidney damage. The integration of ML algorithms improved the analysis, providing high accuracy, selectivity, and specificity in detecting these changes. Moreover, lipids metabolic profiling revealed distinct variations in the concentration of 11 phosphatydylocholines …

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Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency

Anna Błażewicz, Julia Wojnicka, Andreas Martin Grabrucker, Piotr Sosnowski et autres

The present preliminary study aimed to provide a targeted lipidomic analysis of Hashimoto (HT) and non-HT patients with well-controlled hypothyroidism as well as in healthy adults, and is the first to demonstrate the association of several components of the human lipidome with …

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Application of Human Plasma Targeted Lipidomics and Analysis of Toxic Elements to Capture the Metabolic Complexities of Hypothyroidism

Anna Błażewicz, Michał Kiełbus, Katarzyna Skórzyńska-Dziduszko, Andreas Martin Grabrucker et autres

BACKGROUND: Hypothyroidism (HT) affects millions worldwide and can lead to various lipid disorders. The metabolic complexity and the influence of toxic elements in autoimmune and non-autoimmune HT subtypes are not fully understood. This study aimed to investigate the relationships between plasma lipidome, …

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Profiling Metabolites with Antifungal Activities from Endophytic Plant-Beneficial Strains of Pseudomonas chlororaphis Isolated from Chamaecytisus albus (Hack.) Rothm.

Wojciech Sokołowski, Monika Marek-Kozaczuk, Piotr Sosnowski, Ewa Sajnaga et autres

Fungal phytopathogens represent a large and economically significant challenge to food production worldwide. Thus, the application of biocontrol agents can be an alternative. In the present study, we carried out biological, metabolomic, and genetic analyses of three endophytic isolates from nodules of …

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Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1

Alice Legru, Fernando de Assis Batista, Anna Katarzyna Puszko, Anthony Bouillon et autres

fr, ch (code pays fourni par la source)

Development and evaluation of RADA-PDGF2 self-assembling peptide hydrogel for enhanced skin wound healing

Milena Deptuła, Justyna Sawicka, Piotr Sass, Piotr Sosnowski et autres

Background: Wound healing complications affect numerous patients each year, creating significant economic and medical challenges. Currently, available methods are not fully effective in the treatment of chronic or complicated wounds; thus, new methods are constantly sought. Our previous studies showed that a …

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Structure-activity relationship studies and biological properties evaluation of peptidic NRP-1 ligands: Investigation of N-terminal cysteine importance

Anna Katarzyna Puszko, Piotr Sosnowski, Olivier Hermine, Gérard Hopfgartner et autres

Neuropilin-1 (NRP-1) is a major co-receptor of vascular endothelial growth factor receptor-2 (VEGFR-2). It may also stimulate tumour growth and metastasis independently of VEGF-A165. These functions make VEGF-A165/NRP-1 complex formation and its inhibition of great interest, where NRP-1 is the target for …

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Assessing the Potential of Untargeted SWATH Mass Spectrometry-Based Metabolomics to Differentiate Closely Related Exposures in Observational Studies

Frank Klont, Piotr Sosnowski, Daan Kremer, Tim J. Knobbe et autres

Mass spectrometry (MS) is increasingly used in clinical studies to obtain molecular evidence of chemical exposures, such as tobacco smoke, alcohol, and drugs. This evidence can help verify clinical data retrieved through anamnesis or questionnaires and may provide insights into unreported exposures, …

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