Rajesh Isiah

Low-dose nivolumab with neoadjuvant chemotherapy and oral metronomic therapy in borderline resectable oral cavity squamous cell carcinoma: a phase II trial

Praveen Kumar Marimuthu, Chitra Renukaradhya, S. Sahu, A. O. John et autres

Background: Non-surgical management of oral cavity squamous cell carcinoma (OSCC) has poorer outcomes compared to surgery. In borderline resectable tumors, historical neoadjuvant chemotherapy achieves surgical conversion in only about 40%. Combining low-dose immunotherapy and oral metronomic therapy (OMT) with chemotherapy may enhance …

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Clinical outcomes of Early stage Glottic malignancies treated with Radiation Therapy :A Single Institution Experience

Cyril Abraham Saji V, Jino Victor Wilson, Rajendra Benny Kuchipudi, Manu Mathew et autres

Low-dose nivolumab plus induction chemotherapy for locally advanced or unresectable head and neck cancer is associated with high response rates and conversion to definitive therapy

Josh Thomas Georgy, Soumya Susan Regi, Rosh Varghese Georgy, Balu Krishna Sasidharan et autres

Locally advanced head and neck squamous cell carcinoma (LAHNSCC) unresectable at presentation has a dismal survival when radical surgery or definitive chemoradiation is not possible. This ambispective cohort study evaluated the addition of low-dose nivolumab to induction chemotherapy (IC) for locally advanced, …

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Management and Outcomes in Head and Neck Cancer Patients with Malignancy Related Hypercalcaemia, an Oncological Emergency: A Cohort Study from a Tertiary Care Hospital in Tamil Nadu

P Jerome Sunny, Gautam Srinivas Waran, Rajendra Benny Kuchipudi, Swathi Bapani et autres

Introduction: Malignancy-Related Hypercalcaemia (MRH) is a paraneoplastic syndrome often associated with various malignancies but has limited evidence available Head and Neck Cancers (HNC). Head and neck squamous cell carcinomas with MRH is rare but it has a unique propensity to induce hypercalcaemia, …

Pragmatic Patient Choice-Driven Radical Treatment Approach (PRAGRAD) for Very Advanced Unresectable Oral Cavity Cancers

Balu Krishna Sasidharan, Sharief K Sidhique, J. Frank Wilson, Manu Mathew et autres

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Low-Dose Nivolumab with Induction Chemotherapy Improves Responses and Conversion to Radical Therapy in Locally Advanced/Unresectable HNSCC: An Ambispective Real-world Study

Josh Thomas Georgy, Soumya Susan Regi, Rosh Varghese Georgy, Balu Krishna Sasidharan et autres

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Real-World Outcomes of Induction Chemotherapy With or Without Low-Dose Nivolumab for Stage III Non–Small Cell Lung Cancer Ineligible for Up-Front Local Therapy: A Propensity Score–Matched Analysis

Praveen Kumar Marimuthu, Josh Thomas Georgy, Deepa Susan Joy Philip, Ajoy Oommen John et autres

PURPOSE There is a lack of literature on treating stage III non–oncogene-driven non–small cell lung cancer (NSCLC) with low-dose immunotherapy in combination with chemotherapy for patients who are not candidates for local therapy up front. MATERIALS AND METHODS We performed an institutional …

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Neoadjuvant Low-Dose Nivolumab with Carboplatin, Nab-Paclitaxel, Erlotinib, Methotrexate and Celecoxib in Borderline Resectable Oral Cavity Squamous Cell Carcinoma

Praveen Kumar Marimuthu, Chitra Renukaradhya, Shalini Sahu, Ajoy Oommen John et autres

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Feasibility, Safety, and Factors Predicting Completion of CROSS Protocol–Based Neoadjuvant Chemoradiotherapy for Esophageal Squamous Carcinoma: Experience from an Indian Tertiary Care Cancer Center

Suraj Surendran, Geet Midha, Manu Mathew, Rajesh Isiah et autres

Abstract Neoadjuvant chemoradiotherapy (NACRT) using the ChemoRadiotherapy for Oesophageal cancer followed by Surgery Study (CROSS) protocol has improved esophageal cancer outcomes. This study reports the real-world experience of the CROSS regimen for esophageal squamous cell carcinoma (ESCC) regarding its feasibility, safety, and …

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Voice Related Quality of Life (qol) in Volumetric Modulated Arc Therapy (vmat) for Non-laryngeal Head and Neck Malignancies

Suresh Babu, Rajesh Isiah, J Justin Ebenezer Sargunaraj, R. Thejes et autres

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Analysis of the effect of baseline detection and early clearance of ct-DNA, on survival outcomes among patients with advanced EGFR-mutant non-small cell lung cancer

Anjana Joel, Titus Raju Chacko, Ashish Singh, Josh Thomas Georgy et autres

BACKGROUND: To determine if circulating tumor DNA (ct-DNA) dynamics of epidermal growth factor receptor (EGFR) mutation in plasma can identify a subset of patients with EGFR-mutant (EGFR- m) non-small cell lung cancer (NSCLC) with inferior survival outcomes, we analyzed and compared survival …

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504P Real-world outcomes with induction systemic therapy for stage III in eligible for upfront local therapy: Pre vs post immunotherapy era in a tertiary referral centre

P.K. Marimuthu, Ashish Singh, A. Joel, Divya Bala Thumaty et autres

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