Li‐Anne Lim

Enucleation of MNTI - a novel approach

N. Saunders-Clay, Li‐Anne Lim

au (code pays fourni par la source)

Global practice patterns and outcomes for metastatic uveal melanoma treated regionally versus systemically.

Marcus O. Butler, Joseph J. Sacco, Shaheer Khan, Marlana Orloff et autres

e23324 Background: Due to the hepatotropic pattern of metastasis in uveal melanoma (UM), liver directed therapies (LDT) are commonly used for the treatment of advanced disease. The PUMMA meta-analysis (Khoja et al, 2019) assessed patients (pts) with metastatic UM (mUM) treated on …

ca, gb, us, au (code pays fourni par la source)

Microdissection of Distinct Morphological Regions Within Uveal Melanomas Identifies Novel Drug Targets

Elsa Toumi, Luke B. Hesson, Vivian Lin, Dale Wright et autres

Background/Objectives: Uveal melanomas (UMs) are rare but often deadly malignancies that urgently require viable treatment options. UMs often exhibit tumour heterogeneity, with macroscopic and microscopic differences in morphology between different regions of the same tumour. However, to date, the clinical significance of …

au (code pays fourni par la source)

A phase 2 safety and efficacy study of neoadjuvant/adjuvant darovasertib for localized ocular melanoma.

Anthony M. Joshua, Roderick O’Day, William Glasson, David Sia et autres

9510 Background: Darovasertib is a protein kinase C (PKC) inhibitor with meaningful activity in metastatic uveal melanoma (UM) due to its effect on PKC delta downstream of canonical GNAQ/GNA11 mutations. To date, its clinical activity in patients with localized primary disease has …

au, us (code pays fourni par la source)

The Fight Tumour Blindness Registry: Efficient capture of high-quality real-world data in uveal melanoma

Roderick O’Day, Robert M. Conway, Li‐Anne Lim, Michael Giblin et autres

au, nz, gb, ch (code pays fourni par la source)

Pediatric ocular melanoma: a collaborative multicenter study and meta-analysis

Babak Masoomian, Lauren A. Dalvin, Hamid Riazi‐Esfahani, Fariba Ghassemi et autres

us, ir, in, gb, fi, au (code pays fourni par la source)

NADOM trial: Neoadjuvant/adjuvant trial of darovasertib in ocular melanoma (OM).

Roderick O’Day, Max Conway, Li‐Anne Lim, John D. McKenzie et autres

TPS9612 Background: Darovasertib (Daro) is a novel inhibitor of PKC, that has pre-clinical activity in GNAQ/GNA11 tumours including ocular melanoma. A recently completed clinical trial of Daro monotherapy in metastatic OM with a response rate of 11%, and DCR of 78% with …

au, us (code pays fourni par la source)

Lapatinib dysregulates HER2 signaling and impairs the viability of human uveal melanoma cells

Wenying Shu, Janney Z. Wang, Xue Zhu, Ke Wang et autres

Uveal melanoma (UM) is the principal type of intraocular malignancy in adults.Up to 50% of UM patients develop metastatic disease with very poor survival.There are few drugs available to treat the primary or metastatic UM.This study was undertaken to evaluate the anti-cancer …

au, cn, fj (code pays fourni par la source)

Lapatinib dysregulates HER2 signaling and impairs the viability of human uveal melanoma cells

Wenying Shu, Janney Z. Wang, Xue Zhu, Ke Wang et autres

Abstract Although uveal melanoma (UM) is rare, it is the principal type of intraocular malignancy. Up to 50% of UM patients develop metastatic disease with low chances of survival beyond 18 months. At present there are no drugs that are effective in …

cn, au, ru, fj, us, kr (code pays fourni par la source)

Capturing uveal melanoma (UM) global practice patterns and clinical outcomes in the collaborative ocular melanoma natural history (OMNi) study (NCT04588662).

Joseph J. Sacco, Marlana Orloff, Sapna P. Patel, Max Conway et autres

TPS9610 Background: Geographical differences in the management of primary UM, surveillance for recurrence, and care of metastatic disease have emerged based upon local expertise, treatment availability and insurance coverage. We have initiated accrual to OMNi (NCT04588662), an ambispective database developed to provide …

gb, us, au, ca (code pays fourni par la source)

Congenital Hypertrophy of the Retinal Pigment Epithelium (CHRPE) as a Screening Marker for Familial Adenomatous Polyposis (FAP): Systematic Literature Review and Screening Recommendations

L. Bonnet, Robert M. Conway, Li‐Anne Lim

Louis Antoine Bonnet, R Max Conway, Li-Anne Lim University of Sydney, Sydney, New South Wales, AustraliaCorrespondence: Louis Antoine Bonnet, 83 Western Line, RD1, Whanganui, 4571, New Zealand, Tel +64 0273947946, Email labonnet101@gmail.comPurpose: Familial adenomatous polyposis (FAP) has an almost 100% colorectal cancer …

au (code pays fourni par la source)

The application of natural compounds in uveal melanoma drug discovery

Yihe Niu, Ke Wang, Xue Zhu, Stanley Zhang et autres

OBJECTIVES: Uveal melanoma (UM) is the most common primary intraocular tumour in adults. UM has a poor overall prognosis and ~50% of patients progress to metastatic disease that has a median survival of 5.2 months. There are currently no proven pharmacological treatments …

au, fj (code pays fourni par la source)