Roderick O’Day

Uveal Melanoma Treatment: An Update

Alison Hiong, Darvy Dang, Malaka Ameratunga, Roderick O’Day

Uveal melanoma is a rare malignancy arising from uveal tract melanocytes. Definitive treatment options for primary disease include plaque brachytherapy, proton beam radiotherapy and enucleation, which provide high rates of local control, but are associated with vision impairment, reduced quality of life …

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Discrepancies between Fundus Photography and Multimodal Imaging in Mapping of Choroidal Tumor Borders

Darvy Dang, Meghna Burmi, Xavier Hadoux, Daniel McKay et autres

Purpose: Accurate choroidal tumor border mapping is required for their management. We compared border mapping accuracy between unimodal assessment (color fundus photography [CFP] or scanning laser ophthalmoscopy [SLO]) against a multimodal assessment (CFP, SLO, and OCT) and identified tumor characteristics that affect …

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The Burden of Treatment for Sporadic Unilateral Retinoblastoma in Australia

Olivia Rolfe, James E. Elder, John D. McKenzie, Anu Mathew et autres

BACKGROUND: The objective of this study was to compare the burden of treatment of different primary treatment modalities for unilateral sporadic retinoblastoma. METHODS: Sixty individuals with unilateral sporadic retinoblastoma were treated at the Royal Children's Hospital Melbourne, Australia, between January 2000 and …

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Systemic Surveillance Guidelines for Uveal Melanoma: A Systematic Review

Farzana Y. Zaman, Aisha Ghaus, Mark Shackleton, Damien Kee et autres

BACKGROUND: Uveal melanoma (UM) is the most common primary intraocular tumour. Despite effective local therapies, UM has a high risk of metastatic recurrence, most frequently to the liver. A significant proportion of patients treated definitively for primary UM eventually experience metastatic disease. …

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1602O Enucleation prevention and vision preservation in primary uveal melanoma (UM): Preliminary results from a phase II study of neoadjuvant darovasertib

Marcus O. Butler, David A. Reichstein, Hatem Krema, Meredith McKean et autres

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HIGH-RISK HISTOPATHOLOGICAL FEATURES OF RETINOBLASTOMA FOLLOWING PRIMARY ENUCLEATION

Swathi Kaliki, Vijitha S. Vempuluru, Komal Bakal, Samten Dorji et autres

PURPOSE: To evaluate high-risk histopathological features following primary enucleation of eyes with retinoblastoma and assess the patient outcomes across continents. METHODS: A retrospective study of 1,426 primarily enucleated retinoblastoma eyes from five continents. RESULTS: Of all, 923 (65%) were from Asia (AS), …

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A phase 2 safety and efficacy study of neoadjuvant/adjuvant darovasertib for localized ocular melanoma.

Anthony M. Joshua, Roderick O’Day, William Glasson, David Sia et autres

9510 Background: Darovasertib is a protein kinase C (PKC) inhibitor with meaningful activity in metastatic uveal melanoma (UM) due to its effect on PKC delta downstream of canonical GNAQ/GNA11 mutations. To date, its clinical activity in patients with localized primary disease has …

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The Fight Tumour Blindness Registry: Efficient capture of high-quality real-world data in uveal melanoma

Roderick O’Day, Robert M. Conway, Li‐Anne Lim, Michael Giblin et autres

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Intraocular lacrimal gland choristoma

Olivia Rolfe, Sandra E. Staffieri, Anu Matthew, James E. Elder et autres

Ectopic lacrimal glands are rare, particularly intraocularly. We present the case of an infant who presented with a fleshy, vascular intraocular lesion and subsequently developed secondary glaucoma. The patient underwent primary enucleation, which was preferred over diagnostic biopsy due to the likelihood …

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10: Preservation of vision with fully fractionated stereotactic RT for posterior choroidal melanoma.

Claire Phillips, Elena Ungureanu, Mathias Bressel, Roderick O’Day et autres

Apical dose versus volume dose of Ruthenium-106 brachytherapy for uveal melanoma

Jeremy P.M. Flanagan, Lotte S. Fog, Melvin A. Astrahan, Lachie J. Talbot et autres

Objective Ruthenium-106 brachytherapy is commonly used to treat uveal melanomas. Most centres prescribe a radiation dose to the tumour apex that is calculated with the tumour located in the centre of the plaque. Recent work suggests that D 99% —the minimum radiation …

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Intra-arterial chemotherapy for retinoblastoma in Australia: 11-year experience

Yuanzhang Jiao, Roderick O’Day, Anu Mathew, James E. Elder et autres

Background: Intra-arterial chemotherapy (IAC) is increasingly used in managing patients with retinoblastoma. In Australia, IAC is primarily used as a globe-salvage treatment when primary treatment has failed. Methods: A retrospective, single-institution study conducted on consecutive children treated with IAC at the Royal …

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